Results 11 to 20 of about 1,352 (181)

An Unprecedented Triad: Simultaneous Acute Pancreatitis, Axonal Polyneuropathy, and Type 1 Diabetes Mellitus in a Catastrophic Juvenile Lupus Flare [PDF]

Clinical Case Reports
A 14‐year‐old female with juvenile systemic lupus erythematosus (jSLE) presented with a life‐threatening and previously unreported triad: the simultaneous onset of acute pancreatitis, severe axonal polyneuropathy, and autoimmune Type 1 Diabetes (T1D ...
Laiba Hashmi, Fazeela Bibi, Kishan Chand Lohana, Khalil El Abdi, Zonaira Mushahid, Muhammad Asad Asif, Mahnoor Ilyas, Osvani Leyva Matos, Ariba Munam, Muhammad Saad Sammi, Samaha Kanden Mohammed Shafi, Said Hamid Sadat   +11 more
doaj   +3 more sources

Vitronectin, a Novel Urinary Proteomic Biomarker, Promotes Cell Pyroptosis in Juvenile Systemic Lupus Erythematosus

Mediators of Inflammation, 2022
Objective. Identifying new markers of juvenile systemic lupus erythematosus (JSLE) is critical event to predict patient stratification and prognosis. The aim of the present study is to analyze alteration of urinary protein expression and screen potential
Song Zhang, Wenxu Pan, Hongli Wang, Cheng Zhi, Yanhao Lin, Ping Wu, Qi Ren, Ping Wei, Rui Chen, Feng Li, Ying Xie, Chun Kwok Wong, Hong Tang, Zhe Cai, Wanfu Xu, Huasong Zeng   +15 more
doaj   +2 more sources

A novel potential target of IL‐35‐regulated JAK/STAT signaling pathway in lupus nephritis

Clinical and Translational Medicine, 2021
Background In this study, we have investigated the potential regulatory mechanisms of IL‐35 to relieve lupus nephritis (LN) through regulating Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway in mesangial ...
Zhe Cai, Song Zhang, Ping Wu, Qi Ren, Ping Wei, Ming Hong, Yu Feng, Chun Kwok Wong, Hong Tang, Huasong Zeng   +9 more
doaj   +2 more sources

Do classic blood biomarkers of JSLE identify active lupus nephritis? Evidence from the UK JSLE Cohort Study [PDF]

Lupus, 2017
Background Lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus (JSLE) patients. The value of commonly available biomarkers, such as anti-dsDNA antibodies, complement (C3/C4), ESR and full blood count parameters in the identification of active LN remains uncertain.
Smith, EMD, Jorgensen, AL, Beresford, MW
openaire   +3 more sources

Neutrophil function in juvenile systemic Lupus Erythematosus (JSLE) [PDF]

, 2014
Objectives This project aimed to investigate the abnormal neutrophil functions in terms of cell survival, phagocytosis, ROS production and chemotaxis in JSLE patients. Furthermore, factors that could affect normal neutrophil functions (such as patient sera, recombinant human cytokines and commonly-used medications) were investigated.
Chiewchengchol, Direkrit
openaire   +3 more sources

COVID19‐Related Onset and Relapses of Juvenile Systemic Lupus Erythematosus‐Like Disease [PDF]

J Paediatr Child Health
Journal of Paediatrics and Child Health, Volume 61, Issue 8, Page 1318-1321, August 2025.
Chiara Cannata, Francesca Tirelli, Alessandra Meneghel, Francesco Zulian   +3 more
wiley   +2 more sources

JSLE and the NLRP3 inflammasome – a novel therapeutic target [PDF]

, 2017
Introduction: Juvenile-onset Systemic Lupus Erythematosus (JSLE) is a severe autoimmune disease causing organ damage and long-term morbidity. Impaired clearance of nuclear debris from cells and upregulated circulating damage-associated molecular patterns (DAMPs) and cytokines are thought to trigger cell death and thus, further increase release of pro ...
Gamble, J
core   +6 more sources

Interdisciplinary Clinical Practice Guidelines for patient-centred management of juvenile-onset systemic lupus erythematosus [PDF]

EULAR Rheumatology Open
: Objectives: To develop updated interdisciplinary clinical practice guidelines for the management of juvenile-onset systemic lupus erythematosus (jSLE) in a patient-centred, treat-to-target (T2T) approach.
Kirsten Mönkemöller, Lutz T. Weber, Martin Häusler, Tilmann Kallinich, Susanne Benseler, Hermine I. Brunner, Caroline Bieber, Jürgen Brunner, Christoph Deuter, Gabriele Hahn, Christian Hedrich, Claas Hinze, Anton Hospach, Heike-Katharina Hoyer-Kuhn, Ales Janda, Dirk Kamitz, Min Ae Lee-Kirsch, Ulrich Neudorf, Jörg Reichert, Martin Aringer, Sabine Schanze, Nicolaus Schwerk, Merle Seume, Fabian Speth, Norbert Wagner, Matthias Schneider, Burkhard Tönshoff, Klaus Tenbrock, Dieter Haffner, Catharina Schuetz   +29 more
doaj   +2 more sources

Investigating phagocytic markers in Juvenile-onset Systemic Lupus Erythematosus (JSLE) monocytes and macrophages [PDF]

, 2013
Background Juvenile-onset systemic lupus erythematosus (JSLE) is a chronic, severe, multi-systemic autoimmune disease. Impaired phagocytic function has been implicated as an initial step in the pathogenesis of this disease, in relation to the clearance of cells undergoing apoptosis. The apoptotic process has been shown to be dysregulated in neutrophils,
Harris, David
openaire   +3 more sources

TNFSF4/OX40L and IKZF1/IKAROS Genetic Variant Associations with Egyptian Juvenile Systemic Lupus Erythematosus (JSLE) [PDF]

Biology
Background: The etiopathogenesis of juvenile systemic lupus erythematosus (JSLE), a complex and complicated illness, is unknown. Genetic, environmental, and dysregulated immune system responses are all thought to contribute to the disease’s etiology ...
Zeinab R. Attia, Ahmed M. Amshawee, Ahmed Flayyih Hasan, Dalia Tawfeek Hussein, Rania A. Abd El Azeem, Mohamed M. Zedan, Thuraya M. Mutawi, Nanis S. El-beltagy, Mohamed A. El Basuni   +8 more
doaj   +2 more sources