Results 11 to 20 of about 732 (166)

A novel potential target of IL‐35‐regulated JAK/STAT signaling pathway in lupus nephritis

Clinical and Translational Medicine, 2021
Background In this study, we have investigated the potential regulatory mechanisms of IL‐35 to relieve lupus nephritis (LN) through regulating Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway in mesangial ...
Zhe Cai, Song Zhang, Ping Wu, Qi Ren, Ping Wei, Ming Hong, Yu Feng, Chun Kwok Wong, Hong Tang, Huasong Zeng   +9 more
doaj   +2 more sources

Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests

BMC Ophthalmology, 2023
Background The aim of this study is to investigate the alterations of choroidal thickness (CT) in juvenile systemic lupus erythematosus (JSLE) using enhanced depth imaging optical coherence tomography (EDI-OCT).
Li Ru, Jinping Xu, Zhongjing Lin, Lanfang Cao, Lin Zhang   +4 more
doaj   +1 more source

P47 Cognitive impairment in jSLE – The role of inflammation [PDF]

Poster presentations, 2020
Background Patients with juvenile-onset Systemic Lupus Erythematosus (jSLE) cope with physical and neuropsychiatric symptoms which may interfere with social and professional activities. Mild cognitive impairment may negatively impact quality of life and academic performance.
Beatriz Silva, Sara Ganhão, Mariana Rodrigues, Francisca Aguiar, Iva Brito, Margarida Figueiredo-Braga   +5 more
openaire   +1 more source

Association of rs7574865 G/T polymorphism of STAT4 gene with juvenile onset of systemic lupus erythematosus

Современная ревматология, 2022
Systemic lupus erythematosus (SLE) with juvenile onset (jSLE) is a complex autoimmune disease involving many organs and systems. The single nucleotide polymorphism rs7574865 of the STAT4 (signal switch and transcription activator 4) gene is associated ...
M. Yu. Krylov, M. I. Kaleda, I. A. Guseva, N. V. Konovalova, D. A. Varlamov   +4 more
doaj   +1 more source

TAM receptors in phagocytosis: Beyond the mere internalization of particles

Immunological Reviews, Volume 319, Issue 1, Page 7-26, October 2023., 2023
Summary TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, activated by their ligands GAS6 and PROS1. TAMs are necessary for adult homeostasis in the immune, nervous, reproductive, skeletal, and vascular systems. Among additional cellular functions employed by TAMs, phagocytosis is central for tissue health. TAM receptors are
Tal Burstyn‐Cohen, Roberta Fresia
wiley   +1 more source

Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile‐onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children

Molecular Genetics &Genomic Medicine, Volume 10, Issue 1, January 2022., 2022
As far as we know, our study is the first one that identifies the rs17849502 functional polymorphism of the NCF2 gene may be a genetic risk factor of juvenile‐onset systemic lupus erythematosus (JSLE) in the European population. The results of our pilot work also suggest that it is probably not for other autoimmune rheumatic diseases, such as juvenile ...
Ivan Y. Bakutenko, Irena D. Haurylchyk, Natalia V. Nikitchenko, Elena V. Sechko, Inna A. Kozyro, Alexei M. Tchitchko, Galina M. Batyan, Alexander V. Sukalo, Nadezhda I. Ryabokon   +8 more
wiley   +1 more source

Associations of lymphocyte subpopulations with clinical phenotypes and long-term outcomes in juvenile-onset systemic lupus erythematosus.

PLoS ONE, 2022
ObjectiveJuvenile-onset systemic lupus erythematosus (JSLE) is a complex and heterogeneous immune-mediated disease. Cellular components have crucial roles in disease phenotypes and outcomes.
Butsabong Lerkvaleekul, Nopporn Apiwattanakul, Kanchana Tangnararatchakit, Nisa Jirapattananon, Supanart Srisala, Soamarat Vilaiyuk   +5 more
doaj   +1 more source

Clinical Study on Systemic Lupus Erythematosus Complicated with Knee Bone Infarction

International Journal of Clinical Practice, Volume 2022, Issue 1, 2022., 2022
Objective. The present study aims to (1) analyze the clinical characteristics and related influencing factors of knee bone infarction in systemic lupus erythematosus (SLE) and (2) improve the understanding of SLE complicated with knee bone infarction. Methods.
Gui-Qi Zhu, Hong-Xia Qiu, Xin-mei Ma, Mei-Xia Liu, Ozgur Kasapcopur   +4 more
wiley   +1 more source

Metabolomics Defines Complex Patterns of Dyslipidaemia in Juvenile-SLE Patients Associated with Inflammation and Potential Cardiovascular Disease Risk

Metabolites, 2021
Cardiovascular disease (CVD) is a leading cause of mortality in patients with juvenile-onset systemic lupus erythematosus (JSLE) associated with atherosclerosis.
George A. Robinson, Junjie Peng, Ines Pineda-Torra, Coziana Ciurtin, Elizabeth C. Jury   +4 more
doaj   +1 more source

Successful treatment of pulmonary aspergillosis due to Aspergillus fumigatus in a child affected by systemic lupus erythematosus: A case report from Northeastern Iran

Clinical Case Reports, Volume 9, Issue 5, May 2021., 2021
Amphotericin B (50 mg /day) was effective tocure a6‐year‐old girl with systemic lupus erythematosus affected to a pulmonary infection with Aspergillus fumigatus. Abstract A6‐year‐old girl affected to systemic lupus erythematosus with symptoms of fever, weakness, and lethargy, cough, chest pain, and abnormalchest x‐ray.
Elham Kashefi, Seyed Javad Seyedi, Kamiar Zomorodian, Zahra Zare Shahrabadi, Hossein Zarrinfar   +4 more
wiley   +1 more source