Results 21 to 30 of about 1,352 (181)

Interplay of NF-κB and PPAR-γ transcription factors in patients with juvenile systemic lupus erythematosus [PDF]

Lupus Science and Medicine
Objective Juvenile SLE (jSLE) is an autoimmune disease characterised by the presence of high levels of autoantibodies, predominantly targeting nuclear antigens, resulting in a breakdown of self-tolerance.
Ozgur Kasapcopur, Sezgin Sahin, Amra Adrovic, Kenan Barut, Sinem Durmus, Remise Gelisgen, Hafize Uzun   +6 more
doaj   +2 more sources

Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus [PDF]

Frontiers in Medicine
Background and aimsJuvenile-onset systemic lupus erythematosus (JSLE) is a chronic autoimmune disease affecting individuals under 18, causing multi-system impairment.
Su Jin Park, Moon Bae Ahn, Dae Chul Jeong   +2 more
doaj   +2 more sources

JSLE metabolomics

, 2021
Data on juvenile-onset systemic lupus erythematosus (JSLE) patients from an NMR-based metabolomics platform (Nightingale)
Robinson, G
core   +2 more sources

The role of hsa_circ_0008945 in juvenile-onset systemic lupus erythematosus

BMC Medical Genomics, 2023
Background circular RNAs (circRNAs) play a crucial role in many physiological and pathological processes including juvenile-onset systemic lupus erythematosus (JSLE).
Qifan Wang, Baiye Xu, Qingmei Zhang, Haidao Wang, Shulian Chen, Tingting Chen, Shishan Liang   +6 more
doaj   +1 more source

Systemic lupus erythematosus organ manifestation and disease activity in children based on Mexican systemic lupus erythematosus disease activity index score at East Java, Indonesia

Indian Journal of Rheumatology, 2021
Background: Disease activity in systemic lupus erythematosus (SLE) is associated with organ damage, outcome worsening, comorbidities, and mortalities in the patients.
Zahrah Hikmah, Anang Endaryanto, I Dewa Gede Ugrasena   +2 more
doaj   +1 more source

Analysis of choroidal thickness in juvenile systemic lupus erythematosus and its correlation with laboratory tests

BMC Ophthalmology, 2023
Background The aim of this study is to investigate the alterations of choroidal thickness (CT) in juvenile systemic lupus erythematosus (JSLE) using enhanced depth imaging optical coherence tomography (EDI-OCT).
Li Ru, Jinping Xu, Zhongjing Lin, Lanfang Cao, Lin Zhang   +4 more
doaj   +1 more source

P47 Cognitive impairment in jSLE – The role of inflammation [PDF]

Poster presentations, 2020
Background Patients with juvenile-onset Systemic Lupus Erythematosus (jSLE) cope with physical and neuropsychiatric symptoms which may interfere with social and professional activities. Mild cognitive impairment may negatively impact quality of life and academic performance.
Beatriz Silva, Sara Ganhão, Mariana Rodrigues, Francisca Aguiar, Iva Brito, Margarida Figueiredo-Braga   +5 more
openaire   +1 more source

Association of rs7574865 G/T polymorphism of STAT4 gene with juvenile onset of systemic lupus erythematosus

Современная ревматология, 2022
Systemic lupus erythematosus (SLE) with juvenile onset (jSLE) is a complex autoimmune disease involving many organs and systems. The single nucleotide polymorphism rs7574865 of the STAT4 (signal switch and transcription activator 4) gene is associated ...
M. Yu. Krylov, M. I. Kaleda, I. A. Guseva, N. V. Konovalova, D. A. Varlamov   +4 more
doaj   +1 more source

TAM receptors in phagocytosis: Beyond the mere internalization of particles

Immunological Reviews, Volume 319, Issue 1, Page 7-26, October 2023., 2023
Summary TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, activated by their ligands GAS6 and PROS1. TAMs are necessary for adult homeostasis in the immune, nervous, reproductive, skeletal, and vascular systems. Among additional cellular functions employed by TAMs, phagocytosis is central for tissue health. TAM receptors are
Tal Burstyn‐Cohen, Roberta Fresia
wiley   +1 more source

Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile‐onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children

Molecular Genetics &Genomic Medicine, Volume 10, Issue 1, January 2022., 2022
As far as we know, our study is the first one that identifies the rs17849502 functional polymorphism of the NCF2 gene may be a genetic risk factor of juvenile‐onset systemic lupus erythematosus (JSLE) in the European population. The results of our pilot work also suggest that it is probably not for other autoimmune rheumatic diseases, such as juvenile ...
Ivan Y. Bakutenko, Irena D. Haurylchyk, Natalia V. Nikitchenko, Elena V. Sechko, Inna A. Kozyro, Alexei M. Tchitchko, Galina M. Batyan, Alexander V. Sukalo, Nadezhda I. Ryabokon   +8 more
wiley   +1 more source