Results 41 to 50 of about 585 (130)

Characterization and Genomic Analysis of PALS2, a Novel Staphylococcus Jumbo Bacteriophage

Frontiers in Microbiology, 2021
Staphylococcus aureus is an important human pathogen that can be frequently encountered in clinical and food-processing surroundings. Among the various countermeasures, bacteriophages have been considered to be promising alternatives to antibiotics.
Yoona Lee, Yoona Lee, Bokyung Son, Bokyung Son, Yoyeon Cha, Yoyeon Cha, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu, Sangryeol Ryu   +9 more
doaj   +1 more source

Characterization and application of a lytic jumbo phage ZPAH34 against multidrug-resistant Aeromonas hydrophila

Frontiers in Microbiology, 2023
Aeromonas hydrophila is an emerging foodborne pathogen causing human gastroenteritis. Aeromonas species isolated from food such as seafood presented multidrug-resistance (MDR), raising serious concerns regarding food safety and public health.
Yuting Hou, Zhihao Wu, Li Ren, Yuan Chen, Yong-An Zhang, Yong-An Zhang, Yang Zhou, Yang Zhou, Yang Zhou   +8 more
doaj   +1 more source

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

, 2023
Large-genome bacteriophages (jumbo phages) of theChimalliviridaefamily assemble a nucleus-like compartment bounded by a protein shell that protects the replicating phage genome from host-encoded restriction enzymes and CRISPR/Cas nucleases. While the nuclear shell provides broad protection against host nucleases, it necessitates transport of mRNA out ...
Eray Enustun, Emily G. Armbruster, Jina Lee, Sitao Zhang, Brian A. Yee, Yajie Gu, Amar Deep, Jack T. Naritomi, Qishan Liang, Stefan Aigner, Benjamin A. Adler, Brady F. Cress, Jennifer A. Doudna, Vorrapon Chaikeeratisak, Don W. Cleveland, Majid Ghassemian, Gene W. Yeo, Joe Pogliano, Kevin D. Corbett   +18 more
openaire   +2 more sources

Emerging Aspects of Jumbo Bacteriophages

Infection and Drug Resistance, 2021
Amina Nazir,1,2 Azam Ali,3 Hong Qing,1 Yigang Tong2 1Key Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, Department of Biology, School of Life Sciences, Beijing Institute of Technology, Beijing ...
Nazir A, Ali A, Qing H, Tong Y
doaj  

Subcellular organization of viral particles during maturation of nucleus-forming jumbo phage

Science Advances, 2022
Many eukaryotic viruses assemble mature particles within distinct subcellular compartments, but bacteriophages are generally assumed to assemble randomly throughout the host cell cytoplasm. Here, we show that viral particles of Pseudomonas nucleus-forming jumbo phage PhiPA3 assemble into a ...
Vorrapon Chaikeeratisak, Kanika Khanna, Katrina T. Nguyen, MacKennon E. Egan, Eray Enustun, Emily Armbruster, Jina Lee, Kit Pogliano, Elizabeth Villa, Joe Pogliano   +9 more
openaire   +4 more sources

Biological and Molecular Characterization of a Jumbo Bacteriophage Infecting Plant Pathogenic Ralstonia solanacearum Species Complex Strains

Frontiers in Microbiology, 2021
A jumbo phage infecting Ralstonia solanacearum species complex strains, designated RsoM2USA, was isolated from soil of a tomato field in Florida, United States, and belongs to the family Myoviridae.
Abdelmonim Ali Ahmad, Abdelmonim Ali Ahmad, Hardian Susilo Addy, Hardian Susilo Addy, Qi Huang   +4 more
doaj   +1 more source

Characterization and genomic study of EJP2, a novel jumbo phage targeting antimicrobial resistant Escherichia coli

Frontiers in Microbiology, 2023
The emergence of antimicrobial resistance (AMR) Escherichia coli has noticeably increased in recent years worldwide and causes serious public health concerns.
Dohyeong Jo, Hyeongsoon Kim, Yoona Lee, Jinshil Kim, Sangryeol Ryu   +4 more
doaj   +1 more source

Molecular basis for anti-jumbo phage immunity by AVAST type 5.

Mol Cell
Abstract Jumbo phages protect their genomes from DNA-sensing bacterial defense systems by enclosing them within vesicles and nucleus-like compartments. Very little is known about defense systems specialized to counter these phages. Here, we show that AVAST Type 5 (Avs5) systems, part of the STAND superfamily and spanning three phylogenetic ...
Muralidharan A, Costa AR, Fierlier D, van den Berg DF, van den Bossche H, Zoumaro-Djayoon AD, Rodríguez-Molina A, Pabst M, Pacesa M, Correia BE, Brouns SJJ.   +10 more
europepmc   +3 more sources

Genomic and proteomic characterization of vB_SauM-UFV_DC4, a novel Staphylococcus jumbo phage

Applied Microbiology and Biotechnology, 2023
Abstract Staphylococcusaureus is one of the most relevant mastitis pathogens in dairy cattle, and the acquisition of antimicrobial resistance genes presents a significant health issue in both veterinary and human fields. Among the different strategies to tackle S.
da Silva, Jéssica Duarte, Melo, Luís Daniel Rodrigues, Santos, Sílvio Roberto Branco, Kropinski, Andrew M., Xisto, Mariana Fonseca, Dias, Roberto Sousa, da Silva Paes, Isabela, Vieira, Marcella Silva, Soares, José Júnior Ferreira, Porcellato, Davide, da Silva Duarte, Vinícius, de Paula, Sérgio Oliveira   +11 more
openaire   +3 more sources

Exploring the Enzymatic Activity of Depolymerase Gp531 from Klebsiella Pneumoniae Jumbo Phage Rak2

Virus Research, 2023
Klebsiella pneumoniae poses a major global challenge due to its virulence, multidrug resistance, and nosocomial nature. Thus, bacteriophage-derived proteins are extensively being investigated as a means to combat this bacterium. In this study, we explored the enzymatic specificity of depolymerase gp531, encoded by the jumbo bacteriophage vB_KleM_RaK2 ...
Algirdas Noreika, Jonita Stankevičiūtė, Rasa Rutkienė, Rolandas Meškys, Laura Kalinienė   +4 more
openaire   +4 more sources