Results 21 to 30 of about 60 (59)

Histone Lysine Demethylase JMJD2D/KDM4D and Family Members Mediate Effects of Chronic Social Defeat Stress on Mouse Hippocampal Neurogenesis and Mood Disorders

Brain Sciences, 2020
Depression, anxiety and related mood disorders are major psychiatric illnesses worldwide, and chronic stress appears to be one of the primary underlying causes.
Swati Maitra, Nitin Khandelwal, Scherazad Kootar, Pooja Sant, Salil S. Pathak, Sujatha Reddy, Annapoorna P. K., Upadhyayula Suryanarayana Murty, Sumana Chakravarty, Arvind Kumar   +9 more
doaj   +1 more source

A New Family of Jumonji C Domain-Containing KDM Inhibitors Inspired by Natural Product Purpurogallin

Frontiers in Chemistry, 2020
Aberrant epigenetic modifications are involved in cancer development. Jumonji C domain-containing histone lysine demethylases (KDMs) are found mainly up-regulated in breast, prostate, and colon cancer.
José A. Souto, Federica Sarno, Angela Nebbioso, Chiara Papulino, Rosana Álvarez, Jessica Lombino, Ugo Perricone, Alessandro Padova, Lucia Altucci, Ángel R. de Lera   +9 more
doaj   +1 more source

Vitamin D and the Epigenome

Frontiers in Physiology, 2014
Epigenetic mechanisms play a crucial role in regulating gene expression. The main mechanisms involve methylation of DNA and covalent modifications of histones by methylation, acetylation, phosphorylation, or ubiquitination.
Irfete S. Fetahu, Julia eHöbaus, Enikö eKallay   +2 more
doaj   +1 more source

Epigenetic Regulation of Wnt Signaling by Carboxamide-Substituted Benzhydryl Amines that Function as Histone Demethylase Inhibitors

iScience, 2020
Summary: Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC).
Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu   +9 more
doaj  

Epigenetic roles of KDM3B and KDM3C in tumorigenesis and their therapeutic implications

Cell Death and Disease
Advances in functional studies on epigenetic regulators have disclosed the vital roles played by diverse histone lysine demethylases (KDMs), ranging from normal development to tumorigenesis.
Jung Yoo, Go Woon Kim, Yu Hyun Jeon, Sang Wu Lee, So Hee Kwon   +4 more
doaj   +1 more source

The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells [PDF]

, 2021
Ziyu Zhang, Baoyu Chen, Yuwen Zhu, Tianyi Zhang, Xiaoling Zhang, Yibiao Yuan, Yong Xu   +6 more
openalex   +1 more source

Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15 [PDF]

, 2022
Lei Duan, Ricardo E. Perez, Sarah Calhoun, Carl G. Maki   +3 more
openalex   +1 more source

Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity

Nature Communications
Arginine methylation of histones plays a critical role in regulating gene expression. The writers (methyltransferases) and readers of methylarginine marks are well-known, but the erasers–arginine demethylases–remain mysterious.
Lixiao Zhou, Xingsen Zhao, Jie Sun, Kun Zou, Xiaoli Huang, Liyang Yu, Mingxuan Wu, Yong Wang, Xuekun Li, Wen Yi   +9 more
doaj   +1 more source

Histone demethylase Jumonji domain‐containing 1A inhibits proliferation and progression of gastric cancer by upregulating runt‐related transcription factor 3 [PDF]

, 2020
Ke Ning, Yangguang Shao, Yuxin He, Fei Wang, Xi Cui, Furong Liu, Danni Li, Feng Li   +7 more
openalex   +1 more source

Demystifying the Role of Histone Demethylases in Colorectal Cancer: Mechanisms and Therapeutic Opportunities

Current Issues in Molecular Biology
Histone demethylases (HDMs) play a pivotal role in colorectal cancer (CRC) progression through dynamic epigenetic regulation. This review summarizes the role and therapeutic potential of HDM in CRC.
Yuanbin Liu, Min Huang, Xia Tian, Xiaodong Huang   +3 more
doaj   +1 more source