Results 21 to 30 of about 6,513 (167)

Involvement of a Jumonji‐C domain‐containing histone demethylase in DRM2‐mediated maintenance of DNA methylation [PDF]

EMBO reports, 2010
Histone demethylases—both lysine‐specific demethylase 1 (LSD1) and Jumonji‐C (JmjC) domain‐containing proteins—are broadly implicated in the regulation of chromatin‐dependent processes. In Arabidopsis thaliana, histone marks directly affect DNA methylation, and mutations in LSD1 homologues show reduced DNA methylation at some loci. We screened transfer
Deleris, Angelique, Greenberg, Maxim, Ausin, Israel, Law, Rona, Moissiard, Guillaume, Schubert, Daniel, Jacobsen, Steven   +6 more
openaire   +4 more sources

A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases [PDF]

Journal of the American Chemical Society, 2011
Histone methylations are important chromatin marks that regulate gene expression, genomic stability, DNA repair, and genomic imprinting. Histone demethylases are the most recent family of histone-modifying enzymes discovered. Here, we report the characterization of a small-molecule inhibitor of Jumonji C domain-containing histone demethylases.
Luo, X, Liu, Y, Kubicek, S, Myllyharju, J, Tumber, A, Ng, S, Che, K, Podoll, J, Heightman, T, Oppermann, U, Schreiber, S, Wang, X   +11 more
openaire   +3 more sources

Histone demethylase Jumonji domain‐containing 1A inhibits proliferation and progression of gastric cancer by upregulating runt‐related transcription factor 3 [PDF]

Cancer Science, 2020
AbstractThe histone demethylase Jumonji domain‐containing 1A (JMJD1A) is overexpressed in multiple cancers and promotes cancer progression. However, the role and mechanism of JMJD1A in gastric cancer (GC) remains poorly understood. Here, we found that JMJD1A could suppress GC cell proliferation and xenograft tumor growth.
Ke Ning, Yangguang Shao, Yuxin He, Fei Wang, Xi Cui, Furong Liu, Danni Li, Feng Li   +7 more
openaire   +2 more sources

PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks [PDF]

, 2020
Post-translational histone modifications and chromatin remodelling play a critical role controlling the integrity of the genome. Here, we identify histone lysine demethylase PHF2 as a novel regulator of the DNA damage response by regulating DNA damage ...
Alonso de la Vega, Ignacio, Attikum, Haico van, Checa Rodríguez, Cintia, Freire, Raimundo, Hernández Fernaud, Juan Ramón, Huertas, Pablo, Paz Cabrera, María Cristina, Rother, Magdalena B, Smits, Veronique A J, Wiegant, Wouter W   +9 more
core   +1 more source

Vitamin C and epigenetics: A short physiological overview

Open Medicine, 2023
In recent years, ascorbic acid (vitamin C) has acquired great interest due to its multiple functions, which results in homeostasis of normal tissues and organs. On the other hand, it has been shown that epigenetic modifications may have an important role
Pavlovic Voja, Ciric Milan, Petkovic Milan, Golubovic Mladjan   +3 more
doaj   +1 more source

Epigenetic Regulation of Wnt Signaling by Carboxamide-Substituted Benzhydryl Amines that Function as Histone Demethylase Inhibitors

iScience, 2020
Summary: Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC).
Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu   +9 more
doaj   +1 more source

Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5

Scientific Reports, 2022
JmjC (Jumonji-C) domain-containing 5 (JMJD5) plays important roles in circadian regulation in plants and humans and is involved in embryonic development and cell proliferation.
Md. Saiful Islam, Marios Markoulides, Rasheduzzaman Chowdhury, Christopher J. Schofield   +3 more
doaj   +1 more source

Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]

, 2014
Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Abidi, Agger, Agger, Aik, Alena Shmakova, Allen, Banka, Barrett, Bersten, Beyer, Black, Clifton, Cloos, Copur, Couture, Cox, Curtis, Dalvai, De Santa, De Santa, Ehrbrecht, Elkins, Ene, Frescas, Frescas, Fukuda, Gearhart, Gildea, Grasso, Hayami, He, Hong, Inagaki, Ivan, Iwamori, Iwase, Jaakkola, Jensen, Jimena Druker, Johnson, Jones, Kauffman, Kenneth, Kleine-Kohlbrecher, Klose, Klose, Koivunen, Kooistra, Kottakis, Krieg, Krieser, Kruidenier, Lagarou, Lan, Lando, Laumonnier, Lee, Lee, Lee, Lee, Li, Liu, Lleres, Lorbeck, Lu, Maltby, Maxwell, Melvin, Melvin, Menon, Michael Batie, Mole, Moniz, Motoyama, Musselman, Narlikar, Niu, Oh, Okada, Okuno, Okuno, Osada, Owen-Hughes, Patani, Pfau, Pollard, Pryor, Ratcliffe, Rivera, Robinson, Robinson, Rocha, Rose, Rotili, Sanchez-Fernandez, Santos, Satoh, Sayegh, Schiller, Schnetz, Schodel, Scibetta, Scibetta, Semenza, Semenza, Shi, Shi, Sonia Rocha, Suzuki, Swygert, Tahiliani, Takeuchi, Tateishi, Tausendschön, Teng, Thinnes, Tie, Trewick, Tsukada, Tsukada, Tzatsos, Tzschach, Vinatzer, Wagner, Wang, Wang, Wang, Weber, Wellmann, Whetstine, Wissmann, Woon, Wozniak, Yamane, Yang, Yates, Yu, Zentner, Zhang, Zhou   +139 more
core   +5 more sources

Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]

, 2018
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang, Lau, Bonnie, Lau, Wayne Bond, Tang, Kexin, Wang, Hongjing, Wang, Wei, Wang, Xin, Wei, Yuquan, Xu, Lian, Yang, Qilian, Yang, Yuqing, Yang, Zhengnan, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Nianxin, Zhou, Shengtao   +16 more
core   +2 more sources

Cooperation between ETS variant 2 and Jumonji domain‑containing 2 histone demethylases

Molecular Medicine Reports, 2018
The E26 transformation-specific (ETS) variant 2 (ETV2) protein, also designated as ETS-related 71, is a member of the ETS transcription factor family and is essential for blood and vascular development in the embryo. The role of ETV2 in cancer has not yet been investigated.
Li, Xiaomeng, Moon, Gene, Shin, Sook, Zhang, Bin, Janknecht, Ralf   +4 more
openaire   +3 more sources