Results 81 to 90 of about 6,513 (167)

Epigenetics in diagnosis, prognostic assessment and treatment of cancer:An update [PDF]

, 2014
Cancer cells contain multiple genetic and epigenetic changes. The relative specificity of many epigenetic changes for neoplastic cells has allowed the identification of diagnostic, prognostic and predictive biomarkers for a number of solid tumors and ...
Briasoulis, Evangelos, Crook, Tim, Hatzimichael, Eleftheria, Lagos, Konstantinos, Sim, Van Ren   +4 more
core   +4 more sources

Histone Lysine Methyltransferase SDG8 Is Involved in Brassinosteroid-Regulated Gene Expression in Arabidopsis thaliana [PDF]

, 2014
Citation: Wang, X., Chen, J., Xie, Z., Liu, S., Nolan, T., Ye, H., et al. (2014). Histone lysine methyltransferase SDG8 is involved in brassinosteroid- regulated gene expression in arabidopsis thaliana.The plant steroid hormones, brassinosteroids (BRs),
Chen, Jiani, Guo, Hongqing, Li, Zhaohu, Liu, Sanzhen, Nolan, Trevor, Schnable, Patrick S., Wang, Xiaolei, Xie, Zhouli, Ye, Huaxun, Yin, Yanhai, Zhang, Mingcai   +10 more
core   +1 more source

An epigenomic threshold hypothesis for integrating dynamic environmental signals into functional models of developmental polyphenisms

Functional Ecology, Volume 39, Issue 11, Page 3050-3060, November 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between developing embryos and a multitude of environmental factors (e.g. climate, nutrition, social cues, stress and anthropogenic contaminants) underlie adaptive and non‐adaptive developmental plasticity and carry broad implications across ecological ...
Benjamin B. Parrott, Samantha L. Bock
wiley   +1 more source

Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]

, 2015
Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C, Kwok, Rosanna S, Lam, Vu H   +2 more
core   +1 more source

Light and Alternating Temperatures Release Seed Dormancy in the Invasive Dipsacus fullonum L. Through ROS Homeostasis and ABA Regulation

Physiologia Plantarum, Volume 177, Issue 6, November/December 2025.
ABSTRACT Seeds have developed mechanisms to perceive environmental signals, such as light and temperature, which govern germination and enhance the chance of seedling establishment. This study examined the foundations of light and temperature sensitivity in the seed dormancy release of a common weed, Dipsacus fullonum.
Paola Frazzetto, Héctor R. Huarte, Giuseppe D. Puglia, Andrey Prjibelski, Shashank Sagar Saini, Valentina Giglio, Sandro Dattilo, Antonia Cristaudo   +7 more
wiley   +1 more source

Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity

Nature Communications
Arginine methylation of histones plays a critical role in regulating gene expression. The writers (methyltransferases) and readers of methylarginine marks are well-known, but the erasers–arginine demethylases–remain mysterious.
Lixiao Zhou, Xingsen Zhao, Jie Sun, Kun Zou, Xiaoli Huang, Liyang Yu, Mingxuan Wu, Yong Wang, Xuekun Li, Wen Yi   +9 more
doaj   +1 more source

Chemical Biology of Lysine Demethylases [PDF]

, 2011
Abnormal levels of DNA methylation and/or histone modifications are observed in patients with a wide variety of chronic diseases. Methylation of lysines within histone tails is a key modification that contributes to increased gene expression or ...
Heightman, Tom D
core   +2 more sources

Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications

Cancer Communications, Volume 45, Issue 10, Page 1247-1284, October 2025.
Abstract Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific protein sites, which alter protein structure, function, stability, and activity ...
Ting Wu, Yingqi Zhao, Xin Zhang, Yuanhe Wang, Qiuchen Chen, Mingrong Zhang, Huan Sheng, Yuying Zhang, Jinyu Guo, Jun Li, Yuxuan Fan, Ziqing Wang, Yalun Li, Haoran Wang, Minjie Wei, Xiaoyun Hu, Huizhe Wu   +16 more
wiley   +1 more source

Undercover: Gene control by metabolites and metabolic enzymes [PDF]

, 2016
To make the appropriate developmental decisions or maintain homeostasis, cells and organisms must coordinate the expression of their genome and metabolic state. However, the molecular mechanisms that relay environmental cues such as nutrient availability
Knaap, J.A. (Jan) van der, Verrijzer, C.P. (Peter)   +1 more
core   +2 more sources

Epi‐Immunotherapy in Cancer Treatment: Mechanisms, Clinical Progress, and Future Directions

Cancer Innovation, Volume 4, Issue 5, October 2025.
Epigenetic regulation of tumor immune evasion and synergistic anticancer strategies via epigenetic‐immunotherapy integration. ABSTRACT Cancer immunotherapy is a groundbreaking therapeutic strategy, yet it continues to face significant challenges, including limited overall response rates and treatment resistance.
Nannan Lu, Guanghua Rong, Weidong Han
wiley   +1 more source