Results 101 to 110 of about 606,579 (281)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Vortex-state-mediated Josephson effect

, 2014
The Josephson effect is a kind of macroscopic quantum phenomenon that supercurrent flows through a Josephson junction without any voltage applied. We predict a novel vortex-state-mediated Josephson effect in an SNS Josephson junction supporting vortices.
Zeng, Zhao Yang, Zhang, Chong
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Accurate, rapid, temperature and liquid-level sensor for cryogenic tanks [PDF]

, 1970
Thermopiles measure ullage gas temperatures to within plus or minus 1.65 deg K between 20 and 300 deg K, and also serve as point liquid-level sensors. Thermopile technique measures smaller temperature differences by keeping the reference junctions inside
De Witt, R. L., Stochl, R. J., Terbeek, H. G.   +2 more
core   +1 more source

Topology-Induced Critical Current Enhancement in Josephson Networks

, 2006
We investigate the properties of Josephson junction networks with inhomogeneous architecture. The networks are shaped as "quare comb" planar lattices on which Josephson junctions link superconducting islands arranged in the plane to generate the ...
A. Trombettoni, Anglin, B. Ruggiero, Barone, Brunelli, Burioni, Burioni, C. Granata, Cataliotti, Chiorescu, Cirillo, Dalfovo, Donley, Fazio, Friedman, Giusiano, Granata, Greiner, Jaksch, Leggett, Leggett, M. Cirillo, M. Russo, Makhlin, Martinis, P. Silvestrini, P. Sodano, R. Russo, Ruggiero, S. Rombetto, Sodano, V. Corato, Van Duzer, Vion, Yu   +34 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Low Temperature Junction Formation for EZ-FET

IEEE Journal of the Electron Devices Society
The EZ-FET is a device with simplified architecture and processing that enables fast electrical characterization of semiconductor films on insulators (SOI) with only two lithography levels and using regular process steps.
N. Zerhouni Abdou, P. Acosta Alba, L. Brunet, F. Milesi, M. Opprecht, M. Gallard, S. Reboh, I. Ionica   +7 more
doaj   +1 more source

Safety monitoring system for radioisotope thermoelectric generators [PDF]

, 1973
System alerts personnel of hazards which may develop while they are performing tests on radioisotope thermoelectric generator (RTG). Remedial action is initiated to minimize damage.
Zoltan, A.
core   +1 more source

Nonequilibrium Andreev bound states population in short superconducting junctions coupled to a resonator

, 2017
Inspired by recent experiments, we study a short superconducting junction of length $L\ll \xi$ (coherence length) inserted in a dc-SQUID containing an ancillary Josephson tunnel junction.
Belzig, Wolfgang, Klees, Raffael L., Rastelli, Gianluca   +2 more
core   +1 more source