Results 111 to 120 of about 616,094 (331)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Low Temperature Junction Formation for EZ-FET

IEEE Journal of the Electron Devices Society
The EZ-FET is a device with simplified architecture and processing that enables fast electrical characterization of semiconductor films on insulators (SOI) with only two lithography levels and using regular process steps.
N. Zerhouni Abdou, P. Acosta Alba, L. Brunet, F. Milesi, M. Opprecht, M. Gallard, S. Reboh, I. Ionica   +7 more
doaj   +1 more source

Detecting Current Noise with a Josephson Junction in the Macroscopic Quantum Tunneling Regime

, 2006
We discuss the use of a hysteretic Josephson junction to detect current fluctuations with frequencies below the plasma frequency of the junction. These adiabatic fluctuations are probed by switching measurements observing the noise-affected average rate ...
A. V. Timofeev, A.J. Leggett, B. Reulet, C.W.J. Beenakker, D. Esteve, D.E. McCumber, G. Schön, J. Ankerhold, J. Bylander, J. Claudon, J. P. Pekola, J. Salo, J. T. Peltonen, J. Tobiska, J.M. Martinis, J.P. Pekola, J.P. Pekola, K.E. Nagaev, K.K. Likharev, L.S. Levitov, L.S. Levitov, M. Duckheim, M. Meschke, R.K. Lindell, S. Gustavsson, T. Ojanen, T.T. Heikkilä, U. Weiss, V. Brosco, W. Lu, W.C. Stewart, Y.M. Blanter, Yu. Bomze   +32 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Modelling of Solar Cell Junction Temperature for Crystalline Silicon Photovoltaic Module

SiliconPV Conference Proceedings
Determination of the junction temperature of solar cells is critical for accurately evaluating on-site performance of solar modules. It is difficult to acquire the junction temperature of cells because solar cells are laminated and encapsulated in ...
Zewen Chen, Yuehua Yang, Haibo Niu, Youzhang Zhu, Xixiang Xu, Mingzhe Yu, Hong Yang   +6 more
doaj  

Thermal Management Technology of New-generation High-voltage SiC Devices Applied in Rail Transit Traction System

机车电传动, 2020
The wide band-gap devices represented by SiC are becoming the research focus of power semiconductor devices. The new generation of high-voltage packaging is the main packaging form for high-power SiC devices to cope with high-voltage, heat dissipation ...
Kai HE, Xingzhi WANG, En TIAN, Yanping CHEN, Zechun DOU   +4 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Junction Temperature Optical Sensing Techniques for Power Switching Semiconductors: A Review. [PDF]

Micromachines (Basel), 2023
Isa R, Mirza J, Ghafoor S, Mustafa Khan MZ, Qureshi KK.   +4 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Electro-Thermal Modeling and Thermal Analysis of High-Inertia Synchronous Condenser Converters

Electricity
High-inertia energy storage synchronous condenser (HI-ES-SC) is operated through rotor-excited variable-speed mechanisms to provide grid power support. Power devices are exposed to alternating electro-thermal stresses, with significant implications for ...
Jinxin Ouyang, Yaowei Lin, Zhiqi Ye, Yanbo Diao   +3 more
doaj   +1 more source