Results 131 to 140 of about 616,094 (331)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Fractional Models for Thermal Modeling and Temperature Estimation of a Transistor Junction

open access: yesAdvances in Difference Equations, 2011
The thermal behavior of a power transistor mounted on a dissipator is considered in order to estimate the transistor temperature junction using a measure of the dissipator temperature only. The thermal transfers between the electric power applied to the
Guillemard Franck   +6 more
doaj  

Over-Current Capability of Silicon Carbide and Silicon Devices for Short Power Pulses with Copper and Phase Change Materials below the Chip

open access: yesEnergies
An increasing share of fluctuating and intermittent renewable energy sources can cause over-currents (OCs) in the power system. The heat generated during OCs increases the junction temperature of semiconductor devices and could even lead to thermal ...
Shubhangi Bhadoria   +4 more
doaj   +1 more source

Research on Heat Transfer Characteristics of Vapor Chamber Integrated Heat Spreader for Chip Package

open access: yesZhileng xuebao, 2022
The high heat flux and the development of miniaturized chips have restricted the thermal diffusion ability of traditional metal materials. In this study, a vapor chamber with a micro-pin was designed and used in an integrated heat spreader (IHS).
Mao Chunlin   +5 more
doaj  

Refractory oxide insulated thermocouple designed and analyzed for high temperature applications [PDF]

open access: yes, 1969
Study establishes design criteria for constructing high temperature thermocouple to measure nuclear fuel pin temperature. The study included a literature search to determine the compatibility of material useful for thermocouples, a hot zone error ...
Popper, G. F., Zeren, T. Z.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy