Results 81 to 90 of about 5,614 (215)
Analyzing Machupo virus-receptor binding by molecular dynamics simulations [PDF]
, 2014 In many biological applications, we would like to be able to computationally predict mutational effects on affinity in protein-protein interactions. However, many commonly used methods to predict these effects perform poorly in important test cases.
Ellington, Andrew D. +3 more
core +2 more sources
Andean Lima Bean Ecology and Its Potential Contribution to Food Security
Legume Science, Volume 6, Issue 2, June 2024.ABSTRACT The Andean lima bean (ALB) (Phaseolus lunatus L.), also known as “Pallar” in Peru, is a large, semi‐flat, kidney‐shaped rarely investigated legume. This ancestral legume lacks in‐depth scientific reports and is mainly cultivated in the coastal region of the Ica valley. Its consumption dates back to ancient times, as evidenced by archaeological
Isabel Milagros Gavilan‐Figari +4 more
wiley +1 more source
Junin virus‐induced astrocytosis is impaired by iNOS inhibition
Journal of Medical Virology, 2002 AbstractBecause Junin virus (JV) experimental encephalitis of mice and rats is characterized by mild histopathological changes that do not seem to justify per se lethality after intracerebral infection, such a murine model seems adequate to investigate the potential role of inducible nitric oxide synthase (iNOS) as a pathogenic factor. Concomitant with
Gomez, Ricardo Martin +3 more
openaire +3 more sources
Prevalence and Incidence of Parkinson's Disease in Latin America: A Meta‐Analysis
Movement Disorders, Volume 39, Issue 1, Page 105-118, January 2024.Abstract Background Parkinson's disease (PD) is a rapidly growing neurodegenerative disorder, but up‐to‐date epidemiological data are lacking in Latin America. We sought to estimate the prevalence and incidence of PD and parkinsonism in Latin America. Methods We searched Medline, Embase, Scopus, Web of Science, Scientific Electronic Library Online, and
Dani J. Kim +9 more
wiley +1 more source
Therapeutic antibodies: current state and future trends--is a paradigm change coming soon? [PDF]
, 2008 Antibody-based therapeutics currently enjoy unprecedented success, growth in research and revenues, and recognition of their potential. It appears that the promise of the "magic bullet" has largely been realized.
Dimitrov, Dimiter S, Marks, James D
core +1 more source
Antimicrobial peptides for novel antiviral strategies in the current post‐COVID‐19 pandemic
Journal of Peptide Science, Volume 30, Issue 1, January 2024.This review describes the main physicochemical characteristics of antimicrobial peptides, with particular focus on peptides derived from amphibian skin. Summarizing the various antiviral activities of these peptides and the underlying mechanism, this review emphasizes the high potential of these small molecules for the development of new antiviral ...
Maria Rosa Loffredo +3 more
wiley +1 more source
Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production
Frontiers in Microbiology, 2020 Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo +6 more
doaj +1 more source
Phosphoproteomic Analysis Reveals the Importance of Kinase Regulation During Orbivirus Infection. [PDF]
, 2017 Bluetongue virus (BTV) causes infections in wild and domesticated ruminants with high morbidity and mortality and is responsible for significant economic losses in both developing and developed countries.
Emmott, Edward +2 more
core +1 more source
Host Cell Factors as Antiviral Targets in Arenavirus Infection
Viruses, 2012 Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively.
Elsa B. Damonte +6 more
doaj +1 more source
A One Health approach for South American hemorrhagic fevers
CABI One HealthSouth American hemorrhagic fevers (SAHF) include five rodent-borne New World mammarenaviruses. These are Junin, Machupo, Chapare, Guanarito, and Sabia viruses.
Dr Rory Wilson, Dr Ariella Barry
doaj +1 more source