Results 61 to 70 of about 2,897,916 (227)

Mode of antiviral action of the galactose-specific lectin, AJLec, on the Junin virus propagation.

Antiviral Research
Junin virus (JUNV), a member of Arenaviridae, is the causative agent of Argentine hemorrhagic fever (AHF). Available AHF treatments are limited; therefore, development of effective and safe treatments is required.
Shuzo Urata, Meion Lee, Tomoko Tsuruta, Reo Igarashi, Kohsuke Takeda, Hideaki Unno   +5 more
semanticscholar   +1 more source

Human BST-2/tetherin inhibits Junin virus release from host cells and its inhibition is partially counteracted by viral nucleoprotein.

Journal of General Virology, 2020
Bone marrow stromal cell antigen-2 (BST-2), also known as tetherin, is an interferon-inducible membrane-associated protein. It effectively targets enveloped viruses at the release step of progeny viruses from host cells, thereby restricting the further ...
V. R. Zadeh, Shuzo Urata, M. Sakaguchi, J. Yasuda   +3 more
semanticscholar   +1 more source

Junin Virus Infection in Genetically Athymic Mice

Intervirology, 1983
The progression of Junin virus infection was studied in congenitally athymic mice. Immunocompetent littermates were used as infected controls. As expected, the latter developed lethal encephalitis, with viremia and considerable viral replication in the brain.
M C, Weissenbacher, M A, Calello, C J, Quintans, H, Panisse, N M, Woyskowsky, V H, Zannoli   +5 more
openaire   +2 more sources

Immunosuppression in Experimental Junin Virus Infection of Mice

Intervirology, 1980
The effects of cyclophosphamide (CY), anti-mouse thymocyte sera, oxisuran, and cytosine arabinoside were evaluated in adult and newborn mice infected with Junin virus. Treatment with CY was the most effective, Adult mice, which are not normally susceptible to intracerebral infection with 10(3) LD50 of Junin virus, were rendered susceptible by treatment
O A, Giovanniello, M R, Nejamkis, N V, Galassi, N R, Nota   +3 more
openaire   +2 more sources

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

Junin virus‐induced astrocytosis is impaired by iNOS inhibition

Journal of Medical Virology, 2002
AbstractBecause Junin virus (JV) experimental encephalitis of mice and rats is characterized by mild histopathological changes that do not seem to justify per se lethality after intracerebral infection, such a murine model seems adequate to investigate the potential role of inducible nitric oxide synthase (iNOS) as a pathogenic factor. Concomitant with
Gomez, Ricardo Martin, Yep, Alejandra, Schattner, Mirta Ana, Berria, Maria Isabel   +3 more
openaire   +3 more sources

Intracellular lipid droplets are exploited by Junín virus: a nucleoprotein-dependent process.

Journal of Cell Science
Lipid droplets (LDs) are organelles involved in lipid storage, maintenance of energy homeostasis, protein sequestration, signaling events and inter-organelle interactions.
Cecilia Alejandra Vázquez, B. Escudero-Pérez, J. Hayashi, Kristoffer E. Leon, J. Moreira, Mayra Alejandra Castañeda Cataña, Allison Groseth, Melanie Ott, L. Oestereich, C. Muñoz-Fontela, C. García, S. Cordo   +11 more
semanticscholar   +1 more source

Arthropod ectoparasites of synanthropic rodents in northern‐central Italy

Medical and Veterinary Entomology, Volume 39, Issue 4, Page 787-793, December 2025.
The presence of ectoparasites in synanthropic rodents in various Italian provinces was investigated. Eighty‐one Rattus norvegicus, 49 Rattus rattus and 10 Mus musculus were examined Polyplax spinulosa lice, Myobiidae mites, Laelaps echidninus and Notoedres muris were mainly recovered.
Filippo Maria Dini, Silvia Crucitti, Talita Bordoni, Roberta Galuppi   +3 more
wiley   +1 more source

The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers

Проблемы особо опасных инфекций, 2018
Presently, the Arenavirus genus (Arenaviridae family) includes 26 individual species of viruses. It is divided into two main groups – Old World arenaviruses and New World arenaviruses.
T. E. Sizikova, V. N. Lebedev, S. I. Syromyatnikova, S. V. Borisevich   +3 more
doaj   +1 more source

Protection Against Junin Virus by Immunization with Live Tacaribe Virus

Experimental Biology and Medicine, 1965
SummaryAdult guinea pigs immunized with the live Tacaribe virus are able to resist challenge with a large dose of Junin virus to which they are normally susceptible. Sera from the Tacaribe virus-immunized guinea pigs contain abundant homologous antibody demonstrable by both complement-fixation and plaque neutralization tests.
N, TAURASO, A, SHELOKOV
openaire   +2 more sources