Results 211 to 220 of about 75,344 (250)
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International Journal of Laboratory Hematology, 2010
SummaryDrug resistance is the major setback of acute myeloid leukemia (AML) therapy. Notch proteins have demonstrated functional regulation in cell proliferation, differentiation, and apoptosis and thus may affect drug resistance. Our study aimed to identify the Notch‐related gene profile in drug‐resistant AML cells and provide potential strategies for
S, Yan +6 more
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SummaryDrug resistance is the major setback of acute myeloid leukemia (AML) therapy. Notch proteins have demonstrated functional regulation in cell proliferation, differentiation, and apoptosis and thus may affect drug resistance. Our study aimed to identify the Notch‐related gene profile in drug‐resistant AML cells and provide potential strategies for
S, Yan +6 more
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Leukemia Research, 1983
K562/VCR cells, which are resistant to the cytotoxicity of vincristine, were isolated from human erythroleukemia K562 cells. Various compounds that induce erythroid differentiation of K562 cells were tested on K562/VCR cells. Differentiation of K562/VCR cells was not induced by actinomycin D or adriamycin alone, but the resistance of these cells to the
J, Okabe-Kado +4 more
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K562/VCR cells, which are resistant to the cytotoxicity of vincristine, were isolated from human erythroleukemia K562 cells. Various compounds that induce erythroid differentiation of K562 cells were tested on K562/VCR cells. Differentiation of K562/VCR cells was not induced by actinomycin D or adriamycin alone, but the resistance of these cells to the
J, Okabe-Kado +4 more
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Expression of C antigen in transduced K562 cells
Transfusion, 2001BACKGROUND: The Rh blood group system is involved in HDN and transfusion reactions. A retrovirus‐expression system was previously used to show that polypeptides carrying the Rh blood group antigens are encoded by the RHD and RHCE genes. This study investigated the structure of the C antigen.STUDY DESIGN AND METHODS: K562 cells were transduced with full‐
J S, Smythe, D J, Anstee
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c-Jun binding site identification in K562 cells
Journal of Genetics and Genomics, 2011Determining the binding sites of the transcription factor is important for understanding of transcriptional regulation. Transcription factor c-Jun plays an important role in cell growth, differentiation and development, but the binding sites and the target genes are not clearly defined in the whole human genome.
Minli, Li +4 more
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Reduction of extracellular dehydroascorbic acid by K562 cells
Cell Biochemistry and Function, 1996AbstractK562 erythroleukaemic cells produced ascorbate when incubated with dehydroascorbic acid. The reduction depended on the number of cells and on the concentration of dehydroascorbic acid. The observed rate consists of a high affinity (apparent) Km 7 μM, Vmax 3·25 pmol min−1 (106 cells)−1 and a low affinity component, which was non‐saturable up to ...
E, Schweinzer +4 more
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Spontaneous Cytotoxic Earthworm Leukocytes Kill K562 Tumor Cells
Zoological Science, 1995Earthworm coelomocytes may act as effector cells which destroy targets in vitro. In a 51Cr release assay, Lumbricus coelomocyte effectors showed lytic activities of 3-14% against K562 human tumor cells when incubated 1-4 hr at 23 degrees C or 37 degrees C. Cytotoxicity was correlated with effector: target ratio.
M M, Suzuki, E L, Cooper
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Persistent infection of K562 cells by encephalomyocarditis virus
Journal of Virology, 1990Infection of human erythroleukemic K562 cells by encephalomyocarditis virus readily resulted in establishment of persistently infected cultures. In contrast to the usual typical lytic infection by encephalomyocarditis virus, in which trypan blue staining of cells reaches close to 100% by about 15 h postinfection, K562 cell cultures required 3 to 4 days
I U, Pardoe +4 more
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Increased cation transport inmdr1-gene-expressing K562 cells
Cancer Chemotherapy and Pharmacology, 1995Cation-transport properties were compared in a human leukemic cell line (K562) and its vincristine-selected, mdr1-gene-expressing sublines (K562/Vcr30 and K562/Vcr150) by the capacity of the cells to accumulate the potassium analogue thallium (201Tl). Determination of the time course of thallium accumulation in the absence and presence of ouabain, an ...
T, Brismar, A, Gruber, C, Peterson
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K562 cells: a source for embryonic globin chains
Journal of Chromatography B: Biomedical Sciences and Applications, 1991A combination of DEAE-cellulose chromatography and reversed-phase high-performance liquid chromatography (HPLC) has been used to devise a method for generating large quantities of embryonic as well as fetal globin chains. The identity of these globin chains was further confirmed by their tryptic peptide mapping. This technique could, therefore, provide
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[Knock-down of CARMA1 in K562 cells inhibits the invasion and metastasis of K562 cells].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2014To study the effects of caspase recruitment domain membrane-associated guanylate kinase protein 1 (CARMA1) knock-down using RNAi technology on cell proliferation, colony forming, invasion and metastasis of the K562 cells.K562 cells with stably-silenced CARMA1 gene was constructed by lentivirus-mediated RNAi technology.
Fang, Liu +4 more
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