Results 61 to 70 of about 352,958 (260)

The role of SLC12A family of cation-chloride cotransporters and drug discovery methodologies

Journal of Pharmaceutical Analysis, 2023
The solute carrier family 12 (SLC12) of cation-chloride cotransporters (CCCs) comprises potassium chloride cotransporters (KCCs, e.g. KCC1, KCC2, KCC3, and KCC4)-mediated Cl− extrusion, and sodium potassium chloride cotransporters (N[K]CCs, NKCC1, NKCC2,
Shiyao Zhang, Nur Farah Meor Azlan, Sunday Solomon Josiah, Jing Zhou, Xiaoxia Zhou, Lingjun Jie, Yanhui Zhang, Cuilian Dai, Dong Liang, Peifeng Li, Zhengqiu Li, Zhen Wang, Yun Wang, Ke Ding, Yan Wang, Jinwei Zhang   +15 more
doaj  

Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris.

PLoS ONE, 2017
Cation Chloride Cotransporters (CCCs) comprise secondary active membrane proteins mainly mediating the symport of cations (Na+, K+) coupled with chloride (Cl-). They are divided into K+-Cl- outward transporters (KCCs), the Na+-K+-Cl- (NKCCs) and Na+-Cl- (
Anna-Maria Hartmann, Lucie I Pisella, Igor Medina, Hans Gerd Nothwang   +3 more
doaj   +1 more source

Sex and species differences in epithelial transport in rat and mouse kidneys: Modeling and analysis

Frontiers in Physiology, 2022
The goal of this study was to investigate the functional implications of sex and species differences in the pattern of transporters along nephrons in the rat and mouse kidney, as reported by Veiras et al. (J Am Soc Nephrol 28: 3504–3517, 2017). To do so,
Melissa Maria Stadt, Anita T. Layton, Anita T. Layton, Anita T. Layton, Anita T. Layton   +4 more
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Ab initio molecular dynamics calculations of ion hydration free energies [PDF]

Journal of Chemical Physics 130 (20), 204507 (2009), 2009
We apply ab initio molecular dynamics (AIMD) methods in conjunction with the thermodynamic integration or "lambda-path" technique to compute the intrinsic hydration free energies of Li+, Cl-, and Ag+ ions. Using the Perdew-Burke-Ernzerhof functional, adapting methods developed for classical force field applications, and with consistent assumptions ...
arxiv   +1 more source

Role of the cation-chloride-cotransporters in the circadian system

Asian Journal of Pharmaceutical Sciences, 2021
The circadian system plays an immense role in controlling physiological processes in our body. The suprachiasmatic nucleus (SCN) supervises this system, regulating and harmonising the circadian rhythms in our body.
Shihan Salihu, Nur Farah Meor Azlan, Sunday Solomon Josiah, Zhijuan Wu, Yun Wang, Jinwei Zhang   +5 more
doaj  

Computation of Pump-Leak Flux Balance in Animal Cells

Cellular Physiology and Biochemistry, 2014
Background/Aims: Many vital processes in animal cells depend on monovalent ion transport across the plasma membrane via specific pathways. Their operation is described by a set of nonlinear and transcendental equations that cannot be solved analytically.
Igor A. Vereninov, Valentina E. Yurinskaya, Michael A. Model, Florian Lang, Alexey A. Vereninov   +4 more
doaj   +1 more source

The logic of ionic homeostasis: Cations are for voltage, but not for volume. [PDF]

PLoS Computational Biology, 2019
Neuronal activity is associated with transmembrane ionic redistribution, which can lead to an osmotic imbalance. Accordingly, activity-dependent changes of the membrane potential are sometimes accompanied by changes in intracellular and/or extracellular ...
Andrey V Dmitriev, Alexander A Dmitriev, Robert A Linsenmeier   +2 more
doaj   +1 more source

Coordinate modulation of Na-K-2Cl cotransport and K-Cl cotransport by cell volume and chloride [PDF]

American Journal of Physiology-Cell Physiology, 2002
Na-K-2Cl cotransporter (NKCC) and K-Cl cotransporter (KCC) play key roles in cell volume regulation and epithelial Cl− transport. Reductions in either cell volume or cytosolic Cl− concentration ([Cl−]i) stimulate a corrective uptake of KCl and water via NKCC, whereas cell swelling triggers KCl loss via KCC.
Christian Lytle, Thomas J. McManus
openaire   +3 more sources

Non-dipole effects in time delay of photoelectrons from atoms, negative ions, and endohedrals [PDF]

, 2020
In this Letter, we investigate the non-dipole effects in time delay of photoelectrons emitted by multi-electron atoms, negative ions, and respective endohedrals. We present the necessary general formulas in the frame of the random phase approximation with exchange (RPAE) applied to atoms, negative ions, and properly adjusted to endohedrals.
arxiv   +1 more source

WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons

Frontiers in Molecular Neuroscience, 2021
The activation of chloride (Cl−)permeable gamma (γ)-aminobutyric acid type A(GABAA) receptors induces synaptic inhibition in mature and excitation in immature neurons. This developmental “switch” in GABA function controlled by its polarity depends on the
Wee Meng Lim, Wee Meng Lim, Eunice W. M. Chin, Eunice W. M. Chin, Eunice W. M. Chin, Bor Luen Tang, Bor Luen Tang, Tingting Chen, Eyleen L. K. Goh, Eyleen L. K. Goh   +9 more
doaj   +1 more source