The Kainic Acid Models of Temporal Lobe Epilepsy. [PDF]
Experimental models of epilepsy are useful to identify potential mechanisms of epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) model is one of the most commonly used.
Rusina E, Bernard C, Williamson A.
europepmc +7 more sources
Neuroprotective effects of trigonelline in kainic acid-induced epilepsy: Behavioral, biochemical, and functional insights [PDF]
Trigonelline, an alkaloid found in the seeds of Trigonella foenum-graecum L. (fenugreek), has been recognized for its potential in treating various diseases.
Mohammad Faizan+7 more
doaj +2 more sources
Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing [PDF]
Mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with terrible epilepsy syndromes that already begin in infancy. Here we report increased severity of acute kainic acid-induced seizures in adult and juvenile Slack knockout mice ...
David Skrabak+6 more
doaj +2 more sources
Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice [PDF]
There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury.
Omar Mamad+24 more
doaj +2 more sources
Protocol paper: kainic acid excitotoxicity-induced spinal cord injury paraplegia in Sprague–Dawley rats [PDF]
Background Excitotoxicity-induced in vivo injury models are vital to reflect the pathophysiological features of acute spinal cord injury (SCI) in humans.
Anam Anjum+12 more
doaj +2 more sources
Reactive morphology of dividing microglia following kainic acid administration [PDF]
The microglial response to a pathological microenvironment is hallmarked by a change in cellular morphology. Following a pathological stimulus, microglia become reactive and simultaneously divide to create daughter cells.
Tabitha R. F. Green+5 more
doaj +2 more sources
Concise Synthesis of (+)-allo-Kainic Acid via MgI2-Mediated Tandem Aziridine Ring Opening-Formal [3+2] Cycloaddition [PDF]
3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S(N)2' ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been
Aggarwal, Varinder K.+3 more
core +2 more sources
Systemic injection of kainic acid differently affects LTP magnitude depending on its epileptogenic efficiency. [PDF]
Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular method to induce seizures and to potentially affect synaptic plasticity, it can also produce physiological-like oscillations and trigger some forms of long ...
Luz M Suárez+7 more
doaj +2 more sources
Subthreshold Cannabidiol Potentiates Levetiracetam in the Kainic Acid Model of Temporal Lobe Epilepsy: A Pilot Study [PDF]
Refractoriness to antiseizure medications is still a major concern in the pharmacotherapy of epilepsy. For this reason, we decided to evaluate the combination of levetiracetam and cannabidiol, administered at a subthreshold dose, to limit the possible ...
Chiara Lucchi+5 more
doaj +2 more sources
Intrinsic brain network stability during kainic acid‐induced epileptogenesis [PDF]
Objective Altered intrinsic brain networks have been revealed in patients with epilepsy and are strongly associated with network reorganization in the latent period. However, the development and reliability of intrinsic brain networks in the early period
Nastaran Jafari+8 more
doaj +2 more sources