Prosaposin overexpression following kainic acid-induced neurotoxicity.
PLoS ONE, 2014 Because excessive glutamate release is believed to play a pivotal role in numerous neuropathological disorders, such as ischemia or seizure, we aimed to investigate whether intrinsic prosaposin (PS), a neuroprotective factor when supplied exogenously in ...
Hiroaki Nabeka +9 more
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Action of adrenal and gonadal steroid hormones on kainic acid-evoked seizures in a rat model of epileptogenesis [PDF]
Biotechnology & Biotechnological Equipment, 2017 Epilepsy is one of most reported neurological disorders after migraine, stroke and Alzheimer's disease. Empiric clinical data reveal that seizures and epilepsy more likely affect men than women.
Slavina Surcheva +4 more
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Neuroprotective effects of trigonelline in kainic acid-induced epilepsy: Behavioral, biochemical, and functional insights [PDF]
Saudi Pharmaceutical Journal, 2023 Trigonelline, an alkaloid found in the seeds of Trigonella foenum-graecum L. (fenugreek), has been recognized for its potential in treating various diseases.
Mohammad Faizan +7 more
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Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing [PDF]
Communications Biology, 2023 Mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with terrible epilepsy syndromes that already begin in infancy. Here we report increased severity of acute kainic acid-induced seizures in adult and juvenile Slack knockout mice ...
David Skrabak +6 more
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Efficient synthesis of kainic acid analogues [PDF]
ARKIVOC, 2013 The present paper deals with an improved synthesis of two molecular hybrids of AMPA and KA, compounds CIP-A and CIP-B, and their transformation into CIOP-A and CIOP-B, the corresponding amido derivatives. Exploiting the continuous-flow technology, a significant improvement in the synthesis of the glutamate agonists CIP-A and CIP-B was accomplished, in ...
Lucia Tamborini +4 more
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Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice [PDF]
Frontiers in Pharmacology, 2023 There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury.
Omar Mamad +24 more
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Regulation of MAP2, GFAP, and calcium in the CA3 Region Following Kainic Acid Exposure to organotypic hippocampal slice culture [version 3; peer review: 2 approved] [PDF]
F1000Research, 2023 Background Neurodegeneration due to neurotoxicity is one of the phenomena in temporal lobe epilepsy. Experimentally, hippocampal excitotoxicity process can occur due to kainic acid exposure, especially in the CA3 area.
Aulanni'am Aulanni'am +4 more
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Protocol paper: kainic acid excitotoxicity-induced spinal cord injury paraplegia in Sprague–Dawley rats [PDF]
Biological Research, 2022 Background Excitotoxicity-induced in vivo injury models are vital to reflect the pathophysiological features of acute spinal cord injury (SCI) in humans.
Anam Anjum +12 more
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Reactive morphology of dividing microglia following kainic acid administration [PDF]
Frontiers in Neuroscience, 2022 The microglial response to a pathological microenvironment is hallmarked by a change in cellular morphology. Following a pathological stimulus, microglia become reactive and simultaneously divide to create daughter cells.
Tabitha R. F. Green +5 more
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Intrinsic brain network stability during kainic acid‐induced epileptogenesis [PDF]
Epilepsia OpenObjective Altered intrinsic brain networks have been revealed in patients with epilepsy and are strongly associated with network reorganization in the latent period. However, the development and reliability of intrinsic brain networks in the early period
Nastaran Jafari +8 more
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