Results 91 to 100 of about 5,024,889 (297)

Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis

Frontiers in Molecular Neuroscience, 2018
Epilepsies are a group of common neurological diseases exerting a strong burden on patients and society, often lacking clear etiology and effective therapeutical strategies.
Johannes Burtscher, Camilla Bean, Camilla Bean, Luca Zangrandi, Iwona Kmiec, Alexandra Agostinho, Luca Scorrano, Luca Scorrano, Erich Gnaiger, Erich Gnaiger, Christoph Schwarzer   +10 more
doaj   +1 more source

Aromatase: A neuroprotective enzyme [PDF]

, 2013
Estradiol, in addition to its participation in neuroendocrine regulation and sexual behavior, has neuroprotective properties. Different types of brain injury induce the expression of the enzyme aromatase in reactive astroglia.
Azcoitia, I., García-Segura, Luis M., Melcangi, R. C., Sierra, Amanda, Veiga, Sergio   +4 more
core   +2 more sources

Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus

Epilepsia, EarlyView.
Abstract Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine‐induced status epilepticus (PISE) and their potential contributions to
AnnaLin M. Woo, Erik J. Fleischel, Dipan C. Patel, Harald Sontheimer   +3 more
wiley   +1 more source

Prosaposin overexpression following kainic acid-induced neurotoxicity.

PLoS ONE, 2014
Because excessive glutamate release is believed to play a pivotal role in numerous neuropathological disorders, such as ischemia or seizure, we aimed to investigate whether intrinsic prosaposin (PS), a neuroprotective factor when supplied exogenously in ...
Hiroaki Nabeka, Keigo Uematsu, Hiroko Takechi, Tetsuya Shimokawa, Kimiko Yamamiya, Cheng Li, Takuya Doihara, Shouichiro Saito, Naoto Kobayashi, Seiji Matsuda   +9 more
doaj   +1 more source

Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior

Scientific Reports, 2023
Pharmacoresistant temporal lobe epilepsy affects millions of people around the world with uncontrolled seizures and comorbidities, like anxiety, being the most problematic aspects calling for novel therapies.
Vahid Ahli Khatibi, Morteza Salimi, Mona Rahdar, Mahmoud Rezaei, Milad Nazari, Samaneh Dehghan, Shima Davoudi, Mohammad Reza Raoufy, Javad Mirnajafi-Zadeh, Mohammad Javan, Narges Hosseinmardi, Gila Behzadi, Mahyar Janahmadi   +12 more
doaj   +1 more source

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Mary Heng, Peter Detloff, Phillip Wang, Roger Albin   +4 more
core   +1 more source

Vasa Nervorum in rat major pelvic ganglion are innervated by nitrergic nerve fibers [PDF]

, 2013
INTRODUCTION The vasa nervorum comprises a network of small diameter blood vessels that provide blood supply to nerves and ganglia. The cell bodies of autonomic nerves innervating the urogenital organs are housed in the major pelvic ganglia (MPG) in rats.
Ames, Andersson, Appenzeller, Asif Muneer, Benesova, Benesova, Cameron, Cameron, Cameron, Cellek, Cellek, Cellek, Cellek, Chandrasekharan, Chantrain, Chung, Dail, Dashwood, Dixon, Giuliano, Gonzalez‐Hernandez, Hackett, Hlaing, Iadecola, Kalsi, Karl A. Beetson, Kavdia, Kedia, Kobayashi, Low, Mary A. Cotter, Mbaku, McManis, Melikian, Norman E. Cameron, Padma‐Nathan, Porst, Saenz de Tejada, Schirar, Selim Cellek, Sonntag, Stephanie F. Smith, Stuehr, Tabatai, Toda, Toda, Toda, Toque, Vitullo, Wang   +49 more
core   +1 more source

Cannabidiol attenuates epileptic phenotype and increases survival in a mouse model of developmental and epileptic encephalopathy type 1

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathy type 1 (DEE1) is a rare drug‐resistant pediatric epilepsy caused by trinucleotide repeat expansions in the X‐linked ARX gene, leading to elongation of the first polyalanine tract. It presents with early onset tonic seizures or spasms, developmental and cognition delay, and high risk of ...
Lucia Verrillo, Fabio Arturo Iannotti, Denise Drongitis, Katiuscia Martinello, Loredana Poeta, Adriano Barra, Gaetano Terrone, Sergio Fucile, Vincenzo Di Marzo, Maria Giuseppina Miano   +9 more
wiley   +1 more source

Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid

Journal of Biomedical Sciences, 2013
BackgroundThe roles of caspase 3 on the kainic acid-mediated neurodegeneration, dendritic plasticity alteration, neurogenesis, microglial activation and gliosis are not fully understood.
Tsai-Teng Tzeng, H. Tsay, Luping Chang, Chia-Lin Hsu, Tzu-Hsuan Lai, Fong-Lee Huang, Y. Shiao   +6 more
semanticscholar   +1 more source

Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity [PDF]

, 2001
Serine proteases in the adult CNS contribute both to activity-dependent structural changes accompanying learning and to the regulation of excitotoxic cell death.
Davies, B, Davies, C H, Kearns, I R, Lathe, R, Ure, J   +4 more
core   +1 more source