Results 161 to 170 of about 15,508 (221)

Kainic acid neurotoxicity and seizures

Neuropharmacology, 1981
Abstract The effects of anesthetics and anticonvulsants on the neurotoxic effects of kainic acid (2.3 nmol) injected into the rat hippocampus and striatum have been examined with regard to neurochemical, histological and electroencephalographic alterations.
R, Zaczek, M, Nelson, J T, Coyle
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Kainic acid induces apoptosis in neurons

Neuroscience, 1996
Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood.
N A, Simonian, R L, Getz, J C, Leveque, C, Konradi, J T, Coyle   +4 more
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Detoxification enzymes following intrastriatal kainic acid

Neurochemical Research, 1987
A complete explanation of the neurotoxicity that follows kainic acid (KA) injection into the rat striatum is lacking. An assessment of the chronological course after intrastriatal KA injection of the activities of enzymes preferentially concentrated in glia or involved in the detoxification of oxygen metabolites is accomplished.
M R, Cohen, C N, Ramchand, V, Sailer, M, Fernandez, W, McAmis, N, Sridhara, C, Alston   +6 more
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Short Total Synthesis of (−)-Kainic Acid

Organic Letters, 2014
A short total synthesis of (-)-kainic acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition-cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (-)-kainic acid via the stereoselective 1,4-reduction of the pyrroline ...
Kentaro, Oe, Yasufumi, Ohfune, Tetsuro, Shinada   +2 more
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Photostability of Kainic Acid in Seawater

Journal of Agricultural and Food Chemistry, 2007
The environmental degradation of a mixture of domoic acid (DA) and kainic acid (KA) in seawater with and without added transition metals is reported. The association constants for kainic acid with Fe (III) and Cu (II) were determined using (1)H nuclear magnetic resonance (NMR; K1,Fe(III) = 2.27 x 10(12), K2,Fe(III) = 8.99 x 10(8), K1,Cu(II) = 1.38 x 10(
Justina M, Burns, Tracey B, Schock, Michelle H, Hsia, Peter D R, Moeller, John L, Ferry   +4 more
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Stereocontrolled Total Synthesis of (−)-Kainic Acid

Organic Letters, 2007
[reaction: see text] A stereocontrolled total synthesis of (-)-kainic acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant alpha,beta-unsaturated lactone with high diastereoselectivity.
Hiroshi, Sakaguchi, Hidetoshi, Tokuyama, Tohru, Fukuyama   +2 more
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A Concise Route to (−)-Kainic Acid

Organic Letters, 2000
A concise route to (-)-kainic acid from enantiopure (+)-cis-4-carbobenzoxyamino-2-cyclopentenol has been devised by employing concurrent Chugaev syn-elimination and intramolecular ene reaction as the key step.
H, Nakagawa, T, Sugahara, K, Ogasawara
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On the Specificity of Kainic Acid

Science, 1979
The specificity of the neurotoxic agent, kainic acid, for destroying cell bodies while sparing terminals and fibers of passage was examined by infusing this agent into the axons of the dorsal noradrenergic bundle and measuring the degree of depletion of noradrenaline concentrations and the reduction in noradrenaline uptake in cortex and hippocampus ...
S T, Mason, H C, Fibiger
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Kainic acid derivatives with anticonvulsant activity

Neuroscience Letters, 1984
beta-Kainic acid, and the glycine and amino-methylphosphonate derivatives of alpha- and beta-kainic acid, have been injected intracerebroventricularly in DBA/2 mice, that show sound-induced seizure responses. An anticonvulsant effect is observed with marked protection against the tonic and clonic phases of the seizure response.
J F, Collins, A J, Dixon, G, Badman, G, De Sarro, A G, Chapman, G P, Hart, B S, Meldrum   +6 more
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The mechanism of kainic acid neurotoxicity

Nature, 1983
The putative excitatory transmitters glutamate and aspartate, as well as their excitatory analogues, can kill neurones in the central nervous system and may thus be involved in the pathogenesis of various neurodegenerative disorders. Several studies have suggested that postsynaptic receptors are important in the mechanism of toxicity.
J, Garthwaite, G, Garthwaite
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