Results 171 to 180 of about 15,508 (221)
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Ethanol, baclofen, and kainic acid neurotoxicity
Experimental Neurology, 1980Abstract The neurotoxicity induced by intrastriatal injections of kainic acid was greater in rats drinking approximately 4 ml ethanol per day for 16 days before injection than in controls. Intraperitoneal injection of 5 mg/kg baclofen (parachlorophenyl GABA), 30 min before the kainic acid injections had a slight protective action.
E G, McGeer, A, Jakubovic, E A, Singh
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Neuroexcitatory amino acids: phosphonic analogue of kainic acid
Amino Acids, 1992The enantioselective synthesis of phosphonic analogue of kainic acid is described.
M, Tabcheh +3 more
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Intrahippocampal kainic acid reduces glutamine synthetase
Neuroscience, 1990Kainic acid was injected into the hippocampus of rats and glutamine synthetase was measured to determine whether astrocytes are involved in the early effects of this neurotoxic agent. Glutamine synthetase was reduced by 38%, 24 h after the stereotaxic application of 4 nmol of kainic acid to this region.
R A, Waniewski, D, McFarland
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Kainic acid‐induced limbic seizures
Neurology, 1981Surface and depth electroencephalograms (EEGs) were studied after intravenous injections of kainic acid (KA). High frequency oscillations and spikes appeared in the hippocampus at a dose (1 mg per kilogram) that did not affect other structures. Higher doses (greater than or equal to 4 mg per kilogram) led to electrical seizures in limbic structures ...
E W, Lothman +2 more
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Kainic acid and 1′‐hydroxykainic acid from palmariales
Natural Toxins, 1994AbstractThe distribution of kainic acid among various red algae was investigated. Analysis of free amino acids from different populations of Palmaria palmata showed that some were unable to accumulate kainic acid to detectable concentrations, whereas in two dwarf mutants it was a major component of the free amino acid composition.
U P, Ramsey +4 more
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Kainic acid: Neurophysiological and neurotoxic actions
Life Sciences, 1979Abstract Kainic acid, an anthelmintic drug structurally related to glutamate, has excitatory electrophysiological actions on neurons in the vertebrate CNS and at the invertebrate neuromuscular junction. Recently, it has been shown to destroy neuronal cell bodies and dendrites in several regions of the vertebrate CNS, while sparing afferent fibers and
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[Kainic acid and neurobiology].
Ceskoslovenska fysiologie, 2007Kainic acid, the analog of excitatory amino acid L-glutamate, interacts with specific receptors in the central nervous system. During last 25 years it has become a tool for studying many human brain disorders, for example human temporal lobe epilepsy, Huntington's chorea etc.
Vladimír, Riljak +2 more
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Model Studies Towards Kainic Acid
Synlett, 2002A novel photochemical approach to the kainoid ring system is presented alongside model studies to demonstrate its feasibility.
E. S. Greenwood, P. J. Parsons
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Synaptic localization of kainic acid binding sites
Nature, 1981The heterocyclic compound kainic acid (KA) is a potent excitant when applied to mammalian neurones. Lesions caused by injections of KA into the rat striatum and hippocampus cause similar patterns of damage to those seen in Huntington's chorea and status epilepticus, respectively.
A C, Foster +3 more
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Kainic-acid-induced seizures: A developmental study
Developmental Brain Research, 1984Developmental dose-response curves for kainic-acid-induced seizures were generated in rats. Rats at 15-18 days (pups), 33-37 days ( pubescents ) and over 90 days (adults) were administered kainic acid intraperitoneally. Seizures were elicited in all 3 age groups, but some of the behavioral manifestations differed in the pups.
B J, Albala, S L, Moshé, R, Okada
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