Results 31 to 40 of about 15,508 (221)

Aminooxadiazolyl kainic acid reveals that kainic acid receptors contribute to astrocytoma glutamate signaling [PDF]

, 2021
ABSTRACTThe excitatory neurotransmitter glutamate triggers a Ca2+rise and the extension of processes in astrocytes. Our results suggest that kainic acid receptors (KAR) can independently initiate glutamate signaling in astrocytoma U118-MG cells. The natural product kainic acid triggered glioexcitablity in cells and was inhibited by the KAR antagonist ...
Mitra Sadat Tabatabaee, Zhenlin Tian, Julien Gibon, Frederic Menard   +3 more
openaire   +1 more source

Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy

BMC Research Notes, 2017
Background Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and ...
Priscilla Kolibea Mante, Donatus Wewura Adongo, Eric Woode   +2 more
doaj   +1 more source

Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice

Frontiers in Pharmacology, 2022
Objective: Our study aimed to explore whether gasdermin D (GSDMD)-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures.Methods: C57BL/6 mice were randomly divided into sham and epilepsy groups.
Lu Xia, Lu Liu, Yiying Cai, Yiying Zhang, Fangchao Tong, Qiang Wang, Jing Ding, Xin Wang, Xin Wang   +8 more
doaj   +1 more source

Loss of hippocampal neurons after kainate treatment correlates with behavioral deficits. [PDF]

PLoS ONE, 2014
Treating rats with kainic acid induces status epilepticus (SE) and leads to the development of behavioral deficits and spontaneous recurrent seizures later in life.
Gisela H Maia, José L Quesado, Joana I Soares, Joana M do Carmo, Pedro A Andrade, José P Andrade, Nikolai V Lukoyanov   +6 more
doaj   +1 more source

The HDAC6 Inhibitor Trichostatin A Acetylates Microtubules and Protects Axons From Excitotoxin-Induced Degeneration in a Compartmented Culture Model

Frontiers in Neuroscience, 2018
Axon degeneration has been implicated as a pathological process in several neurodegenerative diseases and acquired forms of neural injury. We have previously shown that stabilizing microtubules can protect axons against excitotoxin-induced fragmentation,
Kelsey Hanson, Nan Tian, James C. Vickers, Anna E. King   +3 more
doaj   +1 more source

Epithelium-dependent effect of L-glutamate on airways: involvement of prostaglandins

Mediators of Inflammation, 2002
We investigated the effect of the excitatory amino acid (EAA) receptor agonists L-glutamate, N-methyl-D-aspartate (NMDA), (RS)-a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainic acid on KCl-induced contractions of rabbit tracheal ...
Apostolia A. Hatziefthimiou, Konstantinos I. Gourgoulianis, Paschalis-Adam Molyvdas   +2 more
doaj   +1 more source

MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset

Cell Reports, 2016
Seizures are bursts of excessive synchronized neuronal activity, suggesting that mechanisms controlling brain excitability are compromised. The voltage-gated potassium channel Kv4.2, a major mediator of hyperpolarizing A-type currents in the brain, is a ...
Christina Gross, Xiaodi Yao, Tobias Engel, Durgesh Tiwari, Lei Xing, Shane Rowley, Scott W. Danielson, Kristen T. Thomas, Eva M. Jimenez-Mateos, Lindsay M. Schroeder, Raymund Y.K. Pun, Steve C. Danzer, David C. Henshall, Gary J. Bassell   +13 more
doaj   +1 more source

Preclinical signal for a disease‐modifying effect on seizure cluster severity with intermittent diazepam treatment

Epilepsia, EarlyView.
Abstract Objective In epilepsy, daily treatment provides only symptomatic seizure control, leaving a significant unmet need for a treatment that affects the underlying predisposition to seizures. Here, in a first‐of‐its‐kind study, we test the hypothesis that intermittent treatment of seizure clusters with diazepam in the kainic acid post‐status ...
Qian Wu, Michelle Guignet, Jonathan Vuong, H. Steve White, Wesley T. Kerr, Evelyn K. Shih, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +8 more
wiley   +1 more source

Synchrotron‐generated microbeams as a radiosurgical alternative for drug‐resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective One‐third of patients with epilepsy, particularly those with mesial temporal lobe epilepsy (MTLE), remain resistant to medication. Resective surgery, the gold standard, is highly invasive and carries significant risks. Here, using a mouse model, we explored the potential of microbeam radiation therapy (MRT), a new technique based on ...
Loan Samalens, Camille Beets, Clothilde Courivaud, Sarvenaz Keshmiri, Jean‐François Adam, Paolo Pellicioli, Emmanuel Luc Barbier, Raphaël Serduc, Antoine Depaulis   +8 more
wiley   +1 more source

Dibutyryl Cyclic Adenosine Monophosphate Rescues the Neurons From Degeneration in Stab Wound and Excitotoxic Injury Models

Frontiers in Neuroscience, 2018
Dibutyryl cyclic adenosine monophosphate (dBcAMP), a cell-permeable synthetic analog of cAMP, has been shown to induce astrogliosis in culture. However, the exact mechanism underlying how dBcAMP exerts its function in situ is not clear.
Ebtesam M. Abd-El-Basset, Muddanna S. Rao   +1 more
doaj   +1 more source