Nimesulide limits kainate-induced oxidative damage in the rat hippocampus [PDF]
, 2000 Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-
Ajamieh, Hussam +4 more
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Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]
, 2017 A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Abraham +92 more
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eNeuro, 2018 Visual Abstract Here we describe a novel mouse model of temporal lobe epilepsy (TLE) that moves the site of kainate injection from the rodent dorsal hippocampus (corresponding to the human posterior hippocampus) to the ventral hippocampus (corresponding ...
Zachary Zeidler +5 more
semanticscholar +1 more source
Hypothalamic excitatory amino acid receptors mediate stress-induced tachycardia in rats [PDF]
, 1992 The role of hypothalamic excitatory amino acid (EAA) receptors in mediating the cardiovascular response to stress was examined using conscious chronically instrumented rats.
DiMicco, Joseph A., Soltis, Robert P.
core +2 more sources
Excitatory amino acids and intracellular pH in motoneurons of the isolated frog spinal cord [PDF]
, 1986 Double-barrelled pH-sensitive micro-electrodes were used to measure changes of intracellular and extracellular pH in and around motoneurons of the isolated frog spinal cord during application of excitatory amino acids.
Ammann +20 more
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Indian Journal of Pharmaceutical Education and Research, 2019 Aim: The purpose of this study was to behavioral and neuroprotective efficacy of Celastrus paniculatus Willd. and Sida cordifolia Linn on hippocampus of the brain in kainic acid induced neurodegenerative diseases.
Gajanand R Pujari +2 more
semanticscholar +1 more source
Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]
, 1991 We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core +2 more sources
CNS Neuroscience & Therapeutics, 2018 To explore the role of miR‐181b in alterations of apoptosis and autophagy in the kainic acid (KA)‐induced epileptic juvenile rats via modulating TLR4 and P38/JNK signaling pathway.
Li Wang +6 more
semanticscholar +1 more source
Altered expression of the voltage-gated calcium channel subunit α2δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain. [PDF]
, 2014 The auxiliary α2δ-1 subunit of voltage-gated calcium channels is up-regulated in dorsal root ganglion neurons following peripheral somatosensory nerve damage, in several animal models of neuropathic pain.
Bauer, CS +5 more
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RNAseq analysis of hippocampal microglia after kainic acid-induced seizures
Molecular Brain, 2018 Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well understood.
D. Bosco +12 more
semanticscholar +1 more source