Results 51 to 60 of about 15,508 (221)

Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice

Scientific Reports, 2021
MicroRNAs are short non-coding RNAs that negatively regulate protein levels and perform important roles in establishing and maintaining neuronal network function.
Aoife Campbell, Gareth Morris, Janosch P. Heller, Elena Langa, Elizabeth Brindley, Jesper Worm, Mads Aaboe Jensen, Meghan T. Miller, David C. Henshall, Cristina R. Reschke   +9 more
doaj   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Protective effect of Co-enzyme Q10 on seizure, short term spatial memory and oxidative stress in induced-epileptic rats

مجله دانشگاه علوم پزشکی گرگان, 2014
Background and Objective: Temporal lobe epilepsy is the most common type of epilepsy in human. Patients suffer from spontaneous seizures and memory deficiency.
Baluchnejadmojarad T, Roghani M
doaj  

Marine Excitatory Amino Acids: Structure, Properties, Biosynthesis and Recent Approaches to Their Syntheses

Molecules, 2020
This review considers the results of recent studies on marine excitatory amino acids, including kainic acid, domoic acid, dysiherbaine, and neodysiherbaine A, known as potent agonists of one of subtypes of glutamate receptors, the so-called kainate ...
Valentin A. Stonik, Inna V. Stonik
doaj   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Do Fits Really Beget Fits? The Effect of Previous Epileptic Activity on the Subsequent Induction of the Tetanus Toxin Model of Limbic Epilepsy in the Rat

Neurobiology of Disease, 2001
The effect of pretreatment with either tetanus toxin (in ventral hippocampus) or kainic acid (into dorsal hippocampus, with or without suppression of seizures by phenobarbital) on the subsequent development of epilepsy in rats injected with tetanus toxin
J. Mellanby, A.J. Milward
doaj   +1 more source

Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior

Scientific Reports, 2023
Pharmacoresistant temporal lobe epilepsy affects millions of people around the world with uncontrolled seizures and comorbidities, like anxiety, being the most problematic aspects calling for novel therapies.
Vahid Ahli Khatibi, Morteza Salimi, Mona Rahdar, Mahmoud Rezaei, Milad Nazari, Samaneh Dehghan, Shima Davoudi, Mohammad Reza Raoufy, Javad Mirnajafi-Zadeh, Mohammad Javan, Narges Hosseinmardi, Gila Behzadi, Mahyar Janahmadi   +12 more
doaj   +1 more source

Exendin-4 Pretreatment Attenuates Kainic Acid-Induced Hippocampal Neuronal Death [PDF]

, 2021
Yu-Jeong Ahn, Hyun-Joo Shin, Eunae Jeong, Hyeong-Seok An, Jong Youl Lee, Hyemin Jang, Kyungeun Kim, Jaewoong Lee, Meong Cheol Shin, Gu Seob Roh   +9 more
openalex   +1 more source

Epilepsy surgery: From bench to the clinics

Epilepsia Open, EarlyView.
Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley   +1 more source

Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis

Frontiers in Molecular Neuroscience, 2018
Epilepsies are a group of common neurological diseases exerting a strong burden on patients and society, often lacking clear etiology and effective therapeutical strategies.
Johannes Burtscher, Camilla Bean, Camilla Bean, Luca Zangrandi, Iwona Kmiec, Alexandra Agostinho, Luca Scorrano, Luca Scorrano, Erich Gnaiger, Erich Gnaiger, Christoph Schwarzer   +10 more
doaj   +1 more source