Results 61 to 70 of about 5,024,889 (297)
Cerebellum: an explanation for dystonia? [PDF]
, 2017 Dystonia is a movement disorder that is characterized by involuntary muscle contractions, abnormal movements and postures, as well as by non-motor symptoms, and is due to abnormalities in different brain areas.
Berardelli, Alfredo, Bologna, Matteo
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Evidence-Based Complementary and Alternative Medicine, 2015 Kainic acid (KA) is well known as a chemical compound to study epileptic seizures and neuronal excitotoxicity. KA-induced excitotoxicity causes neuronal death by induction of autophagic stress and microglia-derived neuroinflammation, suggesting that the ...
K. H. Jeong, U. Jung, Sang Ryong Kim
semanticscholar +1 more source
MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset
Cell Reports, 2016 Seizures are bursts of excessive synchronized neuronal activity, suggesting that mechanisms controlling brain excitability are compromised. The voltage-gated potassium channel Kv4.2, a major mediator of hyperpolarizing A-type currents in the brain, is a ...
Christina Gross +13 more
doaj +1 more source
Kainic acid-induced eye enlargement in chickens: differential effects on anterior and posterior segments [PDF]
, 1988 Intravitreal injections of kainic acid were used to examine the significance of normal retinal activity for eye growth in chickens, this acid being chosen because of its known, selective neurotoxic effects on cells in the chicken retina.
Pettigrew, J. D., Wildsoet, C. F.
core
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
β-Kainic acid is not an amino acid antagonist
Journal of Pharmacy and Pharmacology, 1985 Abstract β-Kainic acid has been reported to have anticonvulsant properties. In view of its structural relationship to α-kainic acid it has therefore been tested for antagonist activity at excitatory receptors for N-methylaspartate, quisqualate and α-kainate using anaesthetized rats and brain slice preparations.
Trevor W. Stone, J.F. Collins
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Polarization anatomy of a kainic acid seizure [PDF]
Psychiatry and Clinical Neurosciences, 1997 Abstract Slow voltage‐sensitive dyes work by accumulating in brain tissue and report the average membrane potential of neurons and glia. The voltage‐sensitive dye diO‐C2‐5 was used to monitor the polarization state of 27 brain structures in the rat during a systemically induced, behaviorally mild, kainic acid seizure using a 20 s recording period.
David S. Sacks, Richard M. Dasheiff
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Frontiers in Neuroscience, 2018 Dibutyryl cyclic adenosine monophosphate (dBcAMP), a cell-permeable synthetic analog of cAMP, has been shown to induce astrogliosis in culture. However, the exact mechanism underlying how dBcAMP exerts its function in situ is not clear.
Ebtesam M. Abd-El-Basset +1 more
doaj +1 more source
Tiagabine treatment in kainic acid induced cerebellar lesion of dystonia rat model [PDF]
, 2016 Dystonia is a neurological disorder characterized by excessive involuntary muscle contractions that lead to twisting movements. The exaggerated movements have been studied and have implicated basal ganglia as the point of origin. In more recent studies,
Kotchabhakdi, Naiphinich +2 more
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Modulation of adult-born neurons in the inflamed hippocampus. [PDF]
, 2013 Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer,
Belarbi, Karim, Rosi, Susanna
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