Results 1 to 10 of about 71,106 (270)
Molecular mechanism of biased signaling at the kappa opioid receptor [PDF]
Nature Communications, 2023 Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.
Amal El Daibani +13 more
doaj +6 more sources
Nanobody-enabled monitoring of kappa opioid receptor states [PDF]
Nature Communications, 2020 Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized states ...
Tao Che +13 more
doaj +5 more sources
The Kappa Opioid Receptor: A Promising Therapeutic Target for Multiple Pathologies [PDF]
Frontiers in Pharmacology, 2022 Kappa-opioid receptors (KOR) are widely expressed throughout the central nervous system, where they modulate a range of physiological processes depending on their location, including stress, mood, reward, pain, inflammation, and remyelination.
Martin L. Dalefield +3 more
doaj +3 more sources
In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist [PDF]
Pharmaceuticals, 2022 Kappa-opioid receptor (KOR) antagonists are promising innovative therapeutics for the treatment of the central nervous system (CNS) disorders. The new scaffold opioid ligand, Compound A, was originally found as a mu-opioid receptor (MOR) antagonist but ...
Kristina Puls +6 more
doaj +4 more sources
The kappa opioid receptor: from addiction to depression, and back [PDF]
Frontiers in Psychiatry, 2014 Comorbidity is a major issue in psychiatry that notably associates with more severe symptoms, longer illness duration and higher service utilization.
Laurence eLalanne +3 more
doaj +4 more sources
Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor. [PDF]
Nat Commun, 2023 Despite the increasing number of GPCR structures and recent advances in peptide design, the development of efficient technologies allowing rational design of high-affinity peptide ligands for single GPCRs remains an unmet challenge.
Muratspahić E +23 more
europepmc +2 more sources
Major Depressive Disorder and Kappa Opioid Receptor [PDF]
Translational Perioperative and Pain Medicine, 2016 Major depressive disorder (MDD) is a common psychiatric disease worldwide. The clinical use of tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs)/serotonin–norepinephrine reuptake ...
Wei Li +7 more
openalex +2 more sources
Signaling underlying kappa opioid receptor-mediated behaviors in rodents [PDF]
Frontiers in Neuroscience, 2022 Kappa opioid receptor (KOR) agonists are potentially useful as analgesic and anti-pruritic agents, for prevention and treatment of substance use disorders, and for treatment of demyelinating diseases.
Lee-Yuan Liu-Chen, Peng Huang
doaj +2 more sources
International Journal of Neuropsychopharmacology, 2018 Background The kappa opioid receptor system has been revealed as a potential pharmacotherapeutic target for the treatment of addictions to substances of abuse.
Amelia Dunn +5 more
openalex +2 more sources
A review of the kappa opioid receptor system in opioid use. [PDF]
Neurosci Biobehav RevThe kappa opioid receptor (KOR) system is implicated in dysphoria and as an "anti-reward system" during withdrawal from opioids. However, no clear consensus has been made in the field, as mixed findings have been reported regarding the relationship between the KOR system and opioid use.
Cayir S +7 more
europepmc +3 more sources