Results 41 to 50 of about 71,106 (270)
Neurobiology of Disease, 2001 Opioid receptor-binding autoradiography was used as a way to map sites of altered opioid transmission in a rat model of l-DOPA-induced dyskinesia. Rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathways sustained a 3-week treatment ...
P.A. Johansson +3 more
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Semisynthetic neoclerodanes as kappa opioid receptor probes [PDF]
Bioorganic & Medicinal Chemistry, 2012 Modification of the furan ring of salvinorin A (1), the main active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. Conversion of the furan ring to an aldehyde at the C-12 position (5) has allowed for the synthesis of analogues with new carbon-carbon bonds at that position ...
Lovell, Kimberly M. +10 more
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Journal of Pharmacological Sciences, 2015 In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed
Hitomi Higuchi +4 more
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BJA Open, 2023 Opioids are a mainstay in acute pain management and produce their effects and side effects (e.g., tolerance, opioid-use disorder and immune suppression) by interaction with opioid receptors.
David G. Lambert
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Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands
Frontiers in Pharmacology, 2022 The present study investigated the in vitro pharmacology of the human kappa opioid receptor using multiple assays, including calcium mobilization in cells expressing chimeric G proteins, the dynamic mass redistribution (DMR) label-free assay, and a ...
Chiara Sturaro +11 more
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The Potential of Methocinnamox as a Future Treatment for Opioid Use Disorder: A Narrative Review
Pharmacy, 2022 The opioid epidemic is an ongoing public health crisis, and the United States health system is overwhelmed with increasing numbers of opioid-related overdoses.
Colleen G. Jordan +5 more
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Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats
International Journal of Neuropsychopharmacology, 2019 Background New treatments for stress-related disorders including depression, anxiety, and substance use disorder are greatly needed. Kappa opioid receptors are expressed in the central nervous system, including areas implicated in analgesia and affective
Sarah Page +8 more
semanticscholar +1 more source
Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Opioid peptides and opiate drugs such as morphine, mediate their analgesic effects, but also undesired side effects, mostly through activation of the mu opioid receptor.
Justyna Piekielna-Ciesielska +7 more
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Journal of Neuroscience, 2018 Activation of κ opioid receptors (KORs) produces analgesia and aversion via distinct intracellular signaling pathways, but whether G protein-biased KOR agonists can be designed to have clinical utility will depend on a better understanding of the ...
Antony D. Abraham +8 more
semanticscholar +1 more source
Kappa opioid receptor and oligodendrocyte remyelination
, 2019 Adult oligodendrocyte precursor cells (OPCs) maintain the abilities to differentiate and myelinate denuded axons in demyelinating diseases, such as Multiple Sclerosis (MS), albert often inefficiently. Remyelination therapies seek to enhance endogenous remyelination and represent a promising approach to achieve functional and cellular architectural ...
Fei, Wang, Feng, Mei
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