Results 51 to 60 of about 71,106 (270)
Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression
Brazilian Journal of Medical and Biological Research, 2012 The periaqueductal gray (PAG) has been reported to be a location for opioid regulation of pain and a potential site for behavioral selection in females.
E. Teodorov +4 more
doaj +2 more sources
Role of Opioid Ligands in the Irritable Bowel Syndrome
Canadian Journal of Gastroenterology, 1999 Endogenous opioid peptides – enkephalins, beta-endorphin and dynorphins – are located in specific sites of the brain, the spinal cord, the autonomic ganglia and the enteric nervous system.
Enrico Corazziari
doaj +1 more source
PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
Neuropsychopharmacology, 2018 Opioid receptors are implicated in alcoholism, other addictions, withdrawal, and depression, and are considered potential pharmacological targets for treatment. Our goal in the present study was to compare the availability of kappa opioid receptors (KOR)
A. Vijay +7 more
semanticscholar +1 more source
Cell Communication and Signaling, 2022 Background As a class of the opioid receptors, the kappa opioid receptor (KOR) has been verified to be a potential biomarker and therapeutic target for human malignant tumors.
Han-Ming Huang +6 more
doaj +1 more source
Advanced Science, EarlyView.Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li +13 more
wiley +1 more source
Journal of Clinical Pharmacy and Therapeutics, 2016 Optimal utilization of opioid analgesics is significantly limited by the central nervous system adverse effects and misuse/abuse potential of currently available drugs.
A. Albert-Vartanian +9 more
semanticscholar +1 more source
Advanced Science, EarlyView.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source
Molecular docking study of Papaver alkaloids to some alkaloid receptors [PDF]
Research Journal of Pharmacognosy, 2017 Background and objectives: More than 40 different alkaloids have been obtained from opium the most important of which are morphine, codeine, papaverine, noscapine and tabaine.
A. Nofallah +3 more
doaj
Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors. [PDF]
Proceedings of the National Academy of Sciences, 1988 kappa opioid receptors (kappa receptors) have been characterized in homogenates of guinea pig and rat brain under in vitro binding conditions. kappa receptors were labeled by using the tritiated prototypic kappa opioid ethylketocyclazocine under conditions in which mu and delta opioid binding was suppressed. In the case of guinea pig brain membranes, a
R S, Zukin +4 more
openaire +2 more sources
Advanced Science, EarlyView.Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang +7 more
wiley +1 more source