Results 141 to 150 of about 10,614 (241)

Identification of a Proliferation Gene Cluster Associated with HPV E6/E7 Expression Level and Viral DNA Load in Invasive Cervical Carcinoma

, 2005
Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular mechanisms involved
Anne de La Rochefordière, Christophe Rosty, Dafna Tsafrir, Eytan Domany, F Ferlay, François Radvanyi, Ilan Tsafrir, Jean Paul Thiery, Jérôme Couturier, Martine Peter, Michal Sheffer, Nicolas Stransky, Patricia de Crémoux, Rémy Salmon, Thierry Dorval, Xavier Sastre-Garau   +15 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARalpha and PLZF/RARalpha [PDF]

, 2011
Chromosomal translocations can lead to the formation of chimeric genes encoding fusion proteins such as PML/RARalpha, PLZF/RARalpha, and AML-1/ETO, which are able to induce and maintain acute myeloid leukemia (AML). One key mechanism in leukemogenesis is
Hagemeyer, Heike, Maier, Thorsten Jürgen, Oancea, Claudia, Puccetti, Elena, Roos, Jessica, Ruthardt, Martin, Steinert, Gunnar   +6 more
core  

Strategies for the Viral Exploitation of Nuclear Pore Transport Pathways

Viruses
Viruses frequently exploit the host’s nucleocytoplasmic trafficking machinery to facilitate their replication and evade immune defenses. By encoding specialized proteins and other components, they strategically target host nuclear transport receptors ...
Xin Zhang, Keesiang Lim, Yujia Qiu, Masaharu Hazawa, Richard W. Wong   +4 more
doaj   +1 more source

Epstein-Barr Virus Nuclear Antigen 1 Forms a Complex with the Nuclear Transporter Karyopherin α2 [PDF]

, 1997
Nicole Fischer, Elisabeth Kremmer, Georg Lautscham, Nikolaus Mueller‐Lantzsch, Friedrich A. Grässer   +4 more
openalex   +1 more source

Nucleocytoplasmic transport: a thermodynamic mechanism

, 2009
The nuclear pore supports molecular communication between cytoplasm and nucleus in eukaryotic cells. Selective transport of proteins is mediated by soluble receptors, whose regulation by the small GTPase Ran leads to cargo accumulation in, or depletion ...
Adam SA, Akey CW, Alber F, Bapteste E, Beck M, Becskei A, Ben‐Efraim I, Bickel T, Caspi Y, Catimel B, Cingolani G, Coppey M, Costa M, Cronshaw JM, Dange T, Denning DP, Devos D, Dixon M, Fanara P, Fradin C, Fradin C, Frey S, Grünwald D, Görlich D, Haldane JBS, Harreman MT, Henderson GP, Hinshaw JE, Hodel AE, Hu W, Hübner S, Jovanovic‐Talisman T, Kalab P, Kalderon D, Kapon R, Kobe B, Kopito RB, Kose S, Kotera I, Kubitscheck U, Kustanovich T, Köhler M, Lam MH, Lee SJ, Lyman SK, Mans BJ, Melcák I, Michael Elbaum, Michael WM, Miyamoto Y, Nachury MV, Naim B, Nakielny S, Newmeyer DD, Ossareh‐Nazari B, Pederson T, Pollard VW, Pyhtila B, Ribbeck K, Ribbeck K, Riddick G, Riddick G, Rihs HP, Robbins J, Ronen Benjamine Kopito, Rout MP, Salman H, Schmidt‐Zachmann MS, Schwartz TU, Shah S, Smith A, Stade K, Steggerda SM, Stein WD, Stoffler D, Strawn LA, Timney BL, Tokunaga M, Wen W, Yang Q, Yang W, Yang W, Zeitler B, Zilman A   +83 more
core   +2 more sources

Karyopherin α-2 Mediates MDC1 Nuclear Import through a Functional Nuclear Localization Signal in the tBRCT Domain of MDC1 [PDF]

, 2020
Kamalakannan Radhakrishnan, SeonJoo Park, Seok Won Kim, Gurusamy Hariharasudhan, Seo-Yeon Jeong, In Youb Chang, Jung-Hee Lee   +6 more
openalex   +1 more source

Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing Ras-GTPase-activating protein SH3 domain-binding protein 1 [PDF]

, 2022
Fan Yang, Lin Li, Zhenzhen Mu, Pengyue Liu, Ying Wang, Yue Zhang, Xiuping Han   +6 more
openalex   +1 more source

Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias [PDF]

, 2013
Christopher J. Walker, Joshua J. Oaks, Ramasamy Santhanam, Paolo Neviani, Jason G. Harb, Gregory Ferenchak, Justin J. Ellis, Yosef Landesman, Ann‐Kathrin Eisfeld, N. Gabrail, C. Smith, Michael A. Caligiuri, Peter Hokland, Denis‐Claude Roy, Alistair Reid, Dragana Milojković, John M. Goldman, Jane F. Apperley, Ramiro Garzon, Guido Marcucci, Sharon Shacham, Michael Kauffman, Danilo Perrotti   +22 more
openalex   +1 more source

Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α [PDF]

, 1998
Elena Conti, Marc Uy, L. Leighton, Günter Blobel, John Kuriyan   +4 more
openalex   +1 more source