Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution
Biology Direct, 2010 Background The transition from prokaryotes to eukaryotes was the most radical change in cell organisation since life began, with the largest ever burst of gene duplication and novelty.
Cavalier-Smith Thomas
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Xenopus cell-free extracts and their contribution to the study of DNA replication and other complex biological processes [PDF]
, 2016 Here we discuss the important contributions that cell-free extracts have made to the study of complex biological processes. We provide a brief history of how cell-free extracts of frog eggs were developed to avoid many of the problems that can arise from
Blow, J. Julian, Laskey, Ronald A.
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The karyopherin CRM1 is required for dendritic cell maturation
Immunobiology, 2010 Dendritic cells (DC) are the most potent antigen-presenting cells (APC) of the immune system and are specialized to activate T as well as B cell-dependent immune responses. Mature DC are characterized by expression of CD83, a surface molecule that has been postulated to be required for efficient DC activity.
Jan, Chemnitz +4 more
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ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3 [PDF]
, 2008 ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor.
In Soon Chang +11 more
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Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation [PDF]
, 2014 Phosphorylation by the cyclin-dependent kinase 1 (Cdk1) adjacent to nuclear localization signals (NLSs) is an important mechanism of regulation of nucleocytoplasmic transport. However, no systematic survey has yet been performed in human cells to analyze
Bodaen, Mikael +13 more
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Molecular basis for protection of ribosomal protein L4 from cellular degradation [PDF]
, 2017 Eukaryotic ribosome biogenesis requires the nuclear import of ∼80 nascent ribosomal proteins and the elimination of excess amounts by the cellular degradation machinery.
Hoelz, André, Huber, Ferdinand M.
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Calcium mediated regulation of karyopherin nuclear transport receptors
The FASEB Journal, 2013 Oxidative stress disrupts the normal function of cells and severe stress situations can result in apoptosis. A specific effect of oxidant stress is an increase in cellular calcium levels, which can be mimicked by treatment with the drug thapsigargin, which inhibits Ca 2+ uptake into the ...
Lauren Elizabeth Foltz +3 more
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Stimulation of CK2-dependent Grp94 phosphorylation by the nuclear localization signal peptide. [PDF]
, 2011 The nuclear localization signal sequence (NLS) of SV40 Large T antigen is essential and sufficient for the nuclear translocation of the protein. Phosphorylation often modulates the intracellular distribution of signaling proteins.
Miyata, Yoshihiko +2 more
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Nuclear karyopherin α2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity [PDF]
, 2008 Oleg Gluz +14 more
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Nutritional status modulates box C/D snoRNP biogenesis by regulated subcellular relocalization of the R2TP complex [PDF]
, 2014 BACKGROUND: Box C/D snoRNPs, which are typically composed of box C/D snoRNA and the four core protein components Nop1, Nop56, Nop58, and Snu13, play an essential role in the modification and processing of pre-ribosomal RNA.
Liang Zhao +4 more
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