Results 171 to 180 of about 4,908 (204)

Restoring p53 wild-type conformation in TP53-Y220C-mutant acute myeloid leukemia. [PDF]

Blood
Carter BZ, Mak PY, Ayoub E, Wu X, Ke B, Nishida Y, Futreal A, Ostermann LB, Bedoy AD, Boettcher S, DiNardo CD, Puzio-Kuter A, Poyurovsky MV, Levine A, Andreeff M.   +14 more
europepmc   +1 more source

Ligands binding diffusively to protein target act as inhibitors of protein-protein interactions. [PDF]

PLoS Comput Biol
Jeffries W, Delfing BM, Laracuente XE, Luo X, Olson A, Foreman KW, Lee KH, Petruncio G, De Benedictis V, Paige M, Kehn-Hall K, Lockhart C, Klimov DK.   +12 more
europepmc   +1 more source

Inhibition of CRM1 reverses hypoxia-driven chemoresistance in acute myeloid leukemia via overcoming HIF-1α-mediated lysosomal sequestration. [PDF]

Front Immunol
Feng X, Ding Y, Huang Y, Qin H, Wang X, Zeng Y.   +5 more
europepmc   +1 more source

Role of charge in enhanced nuclear transport and retention of graphene quantum dots. [PDF]

Sci Rep
Gorav G, Khedekar V, Varier GK, Nandakumar P.   +3 more
europepmc   +1 more source

Detection of <i>XPO1</i>^E571K Gene Mutation from Cell-Free DNA in Blood Circulation of Lymphoma Patients by FAST-COLD PCR. [PDF]

Int J Mol Sci
Duangmano S, Viriyaadhammaa N, Khamphikham P, Intasai N, Tantiworawit A, Daroontum T, Chiampanichayakul S, Anuchapreeda S.   +7 more
europepmc   +1 more source

CNS Involvement by North American-Adult T-cell Leukemia/Lymphoma Is Associated With Discrete Dissemination Patterns and Molecular Profiles, Involving XPO1 E571 and KLF2/PI3KCD in Selected Cases. [PDF]

JCO Precis Oncol
Shah N, Suchanek M, Thakkar A, Patel RJ, Rahman S, Acuna-Villaorduna A, Shah U, Adrianzen Herrera D, Slasky S, Gritsman K, Goldfinger M, Shastri A, Mantzaris I, Kornblum N, Bachier-Rodriguez L, Feldman E, Cooper D, McNeill KA, Wang Y, Shi Y, Verma A, Ye BH, Janakiram M, Sica RA.   +23 more
europepmc   +1 more source

Karyopherins and condensates

Current Opinion in Cell Biology, 2020
Several aggregation-prone RNA-binding proteins, including FUS, EWS, TAF15, hnRNP A1, hnRNP A2, and TDP-43, are mutated in neurodegenerative diseases. The nuclear-cytoplasmic distribution of these proteins is controlled by proteins in the karyopherin family of nuclear transport factors (Kaps). Recent studies have shown that Kaps not only transport these
Michael K Rosen, Yuh Min Chook
exaly   +3 more sources

Karyopherins in cancer

Current Opinion in Cell Biology, 2018
Malfunction of nuclear-cytoplasmic transport contributes to many diseases including cancer. Defective nuclear transport leads to changes in both the physiological levels and temporal-spatial location of tumor suppressors, proto-oncogenes and other macromolecules that in turn affect the tumorigenesis process and drug sensitivity of cancer cells.
Tolga Cagatay, Yuh Min Chook
exaly   +4 more sources

Karyopherins in nuclear pore biogenesis [PDF]

Journal of Cell Biology, 2002
The mechanisms that govern the assembly of nuclear pore complexes (NPCs) remain largely unknown. Here, we have established a role for karyopherins in this process. We show that the yeast karyopherin Kap121p functions in the targeting and assembly of the nucleoporin Nup53p into NPCs by recognizing a nuclear localization signal (NLS) in Nup53p.
C Patrick Lusk, Marcello Marelli, John D Aitchison   +2 more
exaly   +2 more sources

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Karyopherin-mediated nucleocytoplasmic transport

Nature Reviews Molecular Cell Biology, 2022
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of the macromolecular traffic across the nuclear pores is mediated by the Karyopherin-β (or Kap) family of nuclear transport receptors.
Casey E. Wing, Ho Yee Joyce Fung, Yuh Min Chook   +2 more
openaire   +2 more sources