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Karyopherins and kissing cousins
Trends in Cell Biology, 1998In eukaryotic cells, a regulated flux of molecules between the cytoplasm and the nucleus maintains two very different environments while allowing the controlled exchange of macromolecules necessary for their individual functions. Molecules entering or leaving the nucleus use nuclear localization signals or nuclear export signals to pass through ...
Richard W Wozniak +2 more
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Karyopherins and nuclear import
Current Opinion in Structural Biology, 2001Proteins of the karyopherin alpha and karyopherin beta families play a central role in nucleocytoplasmic transport. Recently, crystal structures of karyopherin alpha and its complexes with nuclear localization signal peptides, a karyopherin beta2-Ran complex and complexes of full-length and fragments of karyopherin beta1 with import substrates, Ran and
Günter Blobel
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Karyopherin flexibility in nucleocytoplasmic transport
Current Opinion in Structural Biology, 2006Recent structural work on nuclear transport factors of the importin-beta superfamily of karyopherins has shown that these proteins are superhelices of HEAT repeats that are able to assume different conformations in different functional states. The inherent flexibility of these helicoids facilitates the accommodation of different binding partners by an ...
Elena, Conti +2 more
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Karyopherins in nuclear transport of homeodomain proteins during development
Biochimica Et Biophysica Acta - Molecular Cell Research, 2011 Homeodomain proteins are crucial transcription factors for cell differentiation, cell proliferation and organ development. Interestingly, their homeodomain signature structure is important for both their DNA-binding and their nucleocytoplasmic trafficking.
Wenduo Ye, Alan M Tartakoff
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The dynamics of karyopherin-mediated nuclear transport
Biochemistry and Cell Biology, 2001The regulated exchange of proteins and nucleic acids between the nucleus and cytoplasm demands a complex interplay between nuclear pore complexes (NPCs), which provide conduits in the nuclear envelope, and mobile transport receptors (or karyopherins, also known as importins/exportins) that bind and mediate the translocation of cargoes through the NPCs.
M, Marelli +3 more
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Karyopherins: from nuclear-transport mediators to nuclear-function regulators
Trends in Cell Biology, 2004The karyopherin beta (or importin beta) family comprises soluble transport factors that mediate the movement of proteins and RNAs between the nucleus and cytoplasm. Recent studies have extended the role of karyopherins to regulating assembly of the nuclear pore complex (NPC), assembly of the nuclear envelope, mitosis and replication.
Nima, Mosammaparast, Lucy F, Pemberton
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Karyopherin-mediated import of integral inner nuclear membrane proteins
Nature, 2006Targeting of newly synthesized integral membrane proteins to the appropriate cellular compartment is specified by discrete sequence elements, many of which have been well characterized. An understanding of the signals required to direct integral membrane proteins to the inner nuclear membrane (INM) remains a notable exception.
Megan C, King +2 more
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Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas
Journal of Neuro-Oncology, 2012The karyopherin (KPNA) protein family is involved in nucleocytoplasmic trafficking. Increased KPNA levels have been found to predict poor prognosis for a variety of solid tumors, including breast, ovarian, cervical, and prostate cancer, and melanoma. The purpose of this study was to evaluate karyopherin a2 as novel biomarker for astrocytic gliomas of ...
K, Gousias +3 more
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Identification of karyopherin-alpha 2 as an Oct4 associated protein
Journal of Genetics and Genomics, 2008The POU domain transcription factor Oct4 is a master regulator in maintaining self-renewal and pluripotency of embryonic stem (ES) cells. To further explore the functional network of Oct4, the yeast two-hybrid system was used to search for Oct4 interacting proteins.
Xiangqun, Li, Lei, Sun, Ying, Jin
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