Leucine auxotrophic marker for genetic manipulation of <i>Mycobacterium abscessus</i>. [PDF]
Appl Environ MicrobiolGriesser T, Selchow P, Sander P.
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Drug resistance profile of <i>Mycobacterium tuberculosis</i> in China: update until 2024. [PDF]
Front MicrobiolXu Y +5 more
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Research progress on the application of multi-scale computational methods in the research and development of anti-tuberculosis infection drugs. [PDF]
Front PharmacolZhao Y +5 more
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Oxidative stress induces <i>E. coli</i> aryl polyene expression, sensitizing the bacterial stress response and modulating the redox environment of innate immune cells. [PDF]
Microbiol SpectrMarkley RL +8 more
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Evaluation of T-NGS, Xpert Ultra, and Line Probe Assay on Clinical Samples for the Diagnosis of Drug-Resistant Pulmonary Tuberculosis in Rio de Janeiro. [PDF]
Rev Soc Bras Med TropBhering M +11 more
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Structural insight into the mechanism of KatG-mediated isoniazid activation
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Isoniazid, a first-line antibiotic used for the treatment of tuberculosis, is a prodrug that requires activation by the Mycobacterium tuberculosis enzyme KatG. The KatG(S315T) mutation causes isoniazid resistance while the KatG(R463L) variation is thought to be a polymorphism.
John T Belisle +2 more
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Resistance Reversed in KatG Mutants of Mycobacterium tuberculosis [PDF]
Trends in Microbiology, 2019 A peptidomimetic containing a thiazolo ring-fused 2-pyridone (C10) has now been reported to inhibit hypoxia-induced tolerance to isoniazid (INH) in Mycobacterium tuberculosis (Flentie et al., Proc. Natl. Acad. Sci. U. S. A., 2019). The C10 compound could also potentiate the bactericidal activity in aerobically grown bacilli, prevented selection of drug-
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