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Catalase-peroxidase (KatG) Structure and Function
2015Catalase-peroxidases, or KatGs, are fascinating multifunctional enzymes the first of which, from Escherichia coli, was characterized in 1979. The first crystal structure of a KatG from Haloarcula morismortui was reported in 2002 as a homodimer in which the N- and C-terminal domains of each subunit are structurally very similar.
Ignacio Fita +2 more
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KATG: Keyword-Bias-Aware Adversarial Text Generation for Text Classification
Proceedings of the AAAI Conference on Artificial Intelligence, 2022Recent work has shown that current text classification models are vulnerable to small adversarial perturbation to inputs, and adversarial training that re-trains the models with the support of adversarial examples is the most popular way to alleviate the impact of the perturbation.
Lingfeng Shen +2 more
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Biochemistry, 2000
Mycobacterium tuberculosis KatG is a multifunctional heme enzyme responsible for activation of the antibiotic isoniazid. A KatG(S315T) point mutation is found in >50% of isoniazid-resistant clinical isolates. Since isoniazid activation is thought to involve an oxidation reaction, the redox potential of KatG was determined using cyclic voltammetry ...
N L, Wengenack +7 more
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Mycobacterium tuberculosis KatG is a multifunctional heme enzyme responsible for activation of the antibiotic isoniazid. A KatG(S315T) point mutation is found in >50% of isoniazid-resistant clinical isolates. Since isoniazid activation is thought to involve an oxidation reaction, the redox potential of KatG was determined using cyclic voltammetry ...
N L, Wengenack +7 more
openaire +2 more sources
Superoxide Reactivity of KatG: Insights into Isoniazid Resistance Pathways in TB
Journal of the American Chemical Society, 2004To gain insight into the mechanism of INH activation by KatG and to understand how resistance is conferred by the single active-site point mutation of KatG(S315T), we have employed pulse radiolysis as the means to initiate a catalytic pathway capable of mimicking the in vivo oxidation of isoniazid (INH).
Reza A, Ghiladi +2 more
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Mycobacterium tuberculosisKatG Is a Peroxynitritase
Biochemical and Biophysical Research Communications, 1999Mycobacterium tuberculosis resides within the highly oxidative environment of the human macrophage and previous reports have indicated that these mycobacteria are susceptible to reactive nitrogen intermediates including peroxynitrite. This work provides evidence that the Mycobacterium tuberculosis hemoprotein KatG acts as an efficient peroxynitritase ...
N L, Wengenack +3 more
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[Antioxidative function of katG gene in Rhizobium leguminosarum].
Wei sheng wu xue bao = Acta microbiologica Sinica, 2016Catalase-peroxidase KatG can protect bacteria from damage of reactive oxygen species. This study investigated the antioxidative function of catalase - peroxidase gene katG in Rhizobium leguminosarum 3841.katG mutant strain of R. leguminosarum was constructed by homologous recombination.
Yanlin, Zhou +5 more
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Contribution of An “Inactive” Domain To Rapid H2O2Decomposition by KatG
Free Radical Biology and Medicine, 2011Yu Wang, Douglas Goodwin
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