Amplication of 0.7kb Fragment Katg Gene From Clinical Multi Drug Resistant Tuberculosis Isolate in Bali [PDF]
, 2013 During last decade has seen a particular increase in the occurrence of drug-resistant of tuberculosis (DR-TB) and multi-DR strains, such as Isoniazid (INH) resistant strains of M. tuberculosis. INH resistance is more frequently associated with mutations
Dwiputri, A. W. (A) +2 more
core
Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis [PDF]
, 2013 First published online: September 20, 2013BACKGROUND: Improving our understanding of the relationship between the genotype and the drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more accurate molecular diagnostics ...
Ando +34 more
core +1 more source
Viable but Nonculturable State, a Survival Strategy for Salmonella in Aquatic Environments
Water and Environment Journal, EarlyView.Transition of Salmonella from a culturable state to a viable but nonculturable state under various environmental stresses and current methods for detecting viable Salmonella in environmental samples. ABSTRACT In the relentless battle for survival, Salmonella has evolved mechanisms to withstand harsh conditions such as extreme temperatures, fluctuating ...
Sanelisiwe Thinasonke Duze +3 more
wiley +1 more source
Computational approach to understanding the mechanism of action of isoniazid, an anti-TB drug
International Journal of Mycobacteriology, 2014 Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis (MTB), which remains a major cause for morbidity and mortality in several developing countries.
Lingaraja Jena +4 more
doaj +1 more source
Requirement of a Plasmid-Encoded Catalase for Survival of \u3cem\u3eRhizobium etli\u3c/em\u3e CFN42 in a Polyphenol-Rich Environment [PDF]
, 2008 Nitrogen-fixing bacteria collectively called rhizobia are adapted to live in polyphenol-rich environments. The mechanisms that allow these bacteria to overcome toxic concentrations of plant polyphenols have not been clearly elucidated.
Brom, Susana +5 more
core +1 more source
Evaluation of cost-effective total nucleic acids extraction protocols for cultured Mycobacterium tuberculosis; a comparison by PCR amplification of genes associated with drug resistance [PDF]
, 2010 Background The emergence of drug resistant strains of Mycobacterium tuberculosis complex has made the management of tuberculosis difficult. Also, Mycobacterium species has a peculiar cell wall, made of an impermeable complex structure rich in mycolate ...
Adolf K Awua, Edna D Doe, Oti K Gyamfi
core +1 more source
KatG-Mediated Oxidation Leading to Reduced Susceptibility of Bacteria to Kanamycin [PDF]
ACS Omega, 2018 Resistance to antibiotics has become a serious problem for society, and there are increasing efforts to understand the reasons for and sources of resistance. Bacterial-encoded enzymes and transport systems, both innate and acquired, are the most frequent culprits for the development of resistance, although in Mycobacterium tuberculosis, the catalase ...
Peter C. Loewen +6 more
openaire +4 more sources
Surface Plasmon Resonance‐based Biosensing Towards the Detection of Multidrug‐Resistant Tuberculosis
Advanced Photonics Research, Volume 7, Issue 3, March 2026.This study presents the detection of multidrug‐resistant tuberculosis (MDR‐TB) gene targets (InhA, KatG, and RpoB) and their mutations using a surface plasmon resonance (SPR)‐based biosensing platform to monitor target binding on functionalized sensor chips.
Sipho H. Chauke +6 more
wiley +1 more source
Biochemistry and Biophysics ReportsMycobacterium tuberculosis catalase-peroxidase (Mt-KatG) is a bifunctional heme-dependent enzyme that has been shown to activate isoniazid (INH), the widely used antibiotic against tuberculosis (TB).
Brenda Uribe-Vázquez +9 more
doaj +1 more source
Prognostic significance of novel katG mutations in Mycobacterium tuberculosis
International Journal of Mycobacteriology, 2015 By using whole genome sequencing (WGS), researchers are beginning to understand the genetic diversity of Mycobacterium tuberculosis (MTB) and its consequences for the diagnosis of multidrug-resistant tuberculosis (MDR-TB) on a genomic scale. The Global Consortium for Drug-resistant TB Diagnostics (GCDD) conducted a genome scale variant analyses of 366 ...
F Valafar +9 more
openaire +3 more sources