Results 51 to 60 of about 14,110 (214)

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Cardiac ventricular Kir6.1 ATP-sensitive potassium channels: an overlooked effector of cardioprotection

Frontiers in Physiology
IntroductionAdenosine triphosphate (ATP)-sensitive potassium (KATP) channels are octameric structures, comprising a pore-forming homotetramer of Kir6.1 or Kir6.2, with 4 accessory sulphonylurea receptor (SUR) subunits.
Sean Brennan, Samir Makwana, Shen Chen, Lauren R. McGuinness, Moustafa Sweihi, Jacob A. Whitmore, Mahmoud E. Elghayesh, Mahmoud E. Elghayesh, Christopher A. Martin, Noorann Sheikh, Manish Patel, Phoebe Malin, Mark W. Sims, Caroline Dart, Richard D. Rainbow   +14 more
doaj   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Ketones prevent oxidative impairment of hippocampal synaptic integrity through KATP channels.

PLoS ONE, 2015
Dietary and metabolic therapies are increasingly being considered for a variety of neurological disorders, based in part on growing evidence for the neuroprotective properties of the ketogenic diet (KD) and ketones.
Do Young Kim, Mohammed G Abdelwahab, Soo Han Lee, Derek O'Neill, Roger J Thompson, Henry J Duff, Patrick G Sullivan, Jong M Rho   +7 more
doaj   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Effect of mitochondrial potassium channel on the renal protection mediated by sodium thiosulfate against ethylene glycol induced nephrolithiasis in rat model

International Brazilian Journal of Urology, 2015
Purpose: Sodium thiosulfate (STS) is clinically reported to be a promising drug in preventing nephrolithiasis. However, its mechanism of action remains unclear.
N. Baldev, R. Sriram, P.C. Prabu, A. Kurian Gino   +3 more
doaj   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Possible New Strategies for the Treatment of Congenital Hyperinsulinism

Frontiers in Endocrinology, 2020
ObjectiveCongenital hyperinsulinism (CHI) is a rare disease characterized by persistent hypoglycemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants.
Jelena Sikimic, Theresa Hoffmeister, Anne Gresch, Julia Kaiser, Winfried Barthlen, Carmen Wolke, Ilse Wieland, Uwe Lendeckel, Peter Krippeit-Drews, Martina Düfer, Gisela Drews   +10 more
doaj   +1 more source

Critical role of gap junction coupled KATP channel activity for regulated insulin secretion. [PDF]

PLoS Biology, 2006
Pancreatic beta-cells secrete insulin in response to closure of ATP-sensitive K+ (KATP) channels, which causes membrane depolarization and a concomitant rise in intracellular Ca2+ (Cai).
Jonathan V Rocheleau, Maria S Remedi, Butch Granada, W Steven Head, Joseph C Koster, Colin G Nichols, David W Piston   +6 more
doaj   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source