Results 71 to 80 of about 1,219,583 (164)

Myocardial protection by adenosine triphosphate−sensitive potassium channel opener diazoxide involves sulfonylurea receptor 2 subunitCentral MessagePerspective

JTCVS Open
Objective: Pharmacologic openers of adenosine triphosphate-sensitive potassium (KATP) channels mimic ischemic preconditioning and are cardioprotective.
Jie Wang, MD, AlleaBelle Bradshaw, MD, Robert Tryon, PhD, Rachel Pan, Sari D. Holmes, PhD, Colin Nichols, PhD, Jennifer S. Lawton, MD   +6 more
doaj   +1 more source

Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome

JCI Insight, 2020
Cantú syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we ...
Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols   +10 more
doaj   +1 more source

Hydrogen sulfide-mediated cardioprotection against ischemia reperfusion is linked to KATP channel for mitochondrial preservation but not for its distinct preference on interfibrillar mitochondria

Bangladesh Journal of Pharmacology, 2019
Hydrogen sulfide has been shown to protect  myocardium against ischemia-reperfusion injury by preserving interfibrillar mitochondria functional activi-ties than subsarcolemmal mitochondria.
Priyadharshini Chandrasekaran, Sriram Ravindran, Sri Rahavi Boovarahan, Gino A. Kurian   +3 more
doaj   +1 more source

Inhibition of NHE1 Overcomes Temozolomide‐Resistance in Glioblastoma via ROS‐AKT/ERK Axis‐Mediated Autophagy Suppression

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
NHE1 inhibition via HOE‐642 suppresses autophagy through the ROS‐AKT/ERK axis, reversing temozolomide resistance in glioblastoma by disrupting the autophagy‐apoptosis balance and enhancing TMZ sensitivity in vitro and in vivo. ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with temozolomide (TMZ) resistance being a ...
Dan Li, Yuhui Li, Xuan Zheng, Zhuo Wang, Yang Wang, Jun Zhang, Jianxiong Guo, Lei Wang, Jingwu Li, Yongliang Liu, Yufeng Li   +10 more
wiley   +1 more source

Nature's KATP-Channel Knockout

, 1997
We describe here how ion-channel dysfunction in b-cells is associated with the pathogenesis of a potentially lethal condition in newborn children and early infancy.
MJ Dunne, A Aynsley-Green, KJ Lindley
core   +1 more source

Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations [PDF]

, 2010
Objective: The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY).
Shield, JPH, Kapoor, RR, Hussain, K., Rubio-Cabezas, O., Kapoor, R. R., Banerjee, I, Sianhanidou, T, Siahanidou, T., Flanagan, SE, Akcay, T, Akcay, T., Cody, D., Siahanidou, T, Hussain, K, Ellard, S., Mali, G, Cody, D, Shield, JP, Shield, J. P. H., Rubio-Cabezas, O, Mali, G., Schwahn, B., Flanagan, S. E., Murphy, N, Murphy, N., Banerjee, I., Ellard, S, Schwahn, B   +27 more
core   +1 more source

New insights into KATP channel gene mutations and neonatal diabetes mellitus [PDF]

, 2020
The ATP-sensitive potassium channel (KATP channel) couples blood levels of glucose to insulin secretion from pancreatic β-cells. KATP channel closure triggers a cascade of events that results in insulin release.
Phillip J. Stansfeld, Pipatpolkai, Tanadet, Stansfeld, Phillip J., Tanadet Pipatpolkai, Samuel Usher, Usher, Samuel, Frances M. Ashcroft, Ashcroft, Frances M.   +7 more
core   +1 more source

MicroRNA‐Driven Regulation of β‐Cell Function in Type 2 Diabetes: Molecular Mechanisms, Network Insights, and Translational Perspectives

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β‐cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β‐cell compensation and progressive secretory dysfunction.
Lena Eliasson, Alexandros Karagiannopoulos, Mototsugu Nagao, Anna Wendt   +3 more
wiley   +1 more source

Intra‐Islet Paracrine Regulation of Glucagon Secretion During Hypoglycemia, Euglycemia, and Hyperglycemia

Annals of the New York Academy of Sciences, Volume 1563, Issue 1, September 2026.
Glucagon, a counterregulatory hormone released from pancreatic α‐cells, maintains glucose homeostasis by acting as a protective barrier against hypoglycemia and an amplifier of insulin release when glucose levels rise with feeding. In the body, glucagon secretion is regulated by circulating glucose levels, with elevations in amino acids and via other ...
Samaneh Fatehi, Jonathan V. Rocheleau, Michael C. Riddell   +2 more
wiley   +1 more source

Both Mitochondrial KATP Channel Opening and Sarcolemmal KATP Channel Blockage Confer Protection Against Ischemia/Reperfusion-Induced Arrhythmia in Anesthetized Male Rats

, 2010
Aim: This study was performed to assess the effect of selective sarcolemmal adenosine triphosphate (ATP)-sensitive K+ channel (KATP) inhibition and the mitochondrial KATP channel activation on ischemia and reperfusion (I/R)-induced arrhythmias in ...
Ömer Bozdoğan, Ersöz Gonca
core   +1 more source