Results 91 to 100 of about 1,219,583 (164)

The ATP-sensitive K+-channel (KATP) controls early left–right patterning in Xenopus and chick embryos [PDF]

, 2010
Consistent left–right asymmetry requires specific ion currents. We characterize a novel laterality determinant in Xenopus laevis: the ATP-sensitive K+-channel (KATP).
Wade Pearson, Michael Levin, Aw, Sherry, Colin G. Nichols, Shi, Nian-Qing, Sherry Aw, Nian-Qing Shi, Nichols, Colin G., Levin, Michael, Carneiro, Katia, Joseph C. Koster, Pearson, Wade, Katia Carneiro, Koster, Joseph C.   +13 more
core   +1 more source

KATP channel expression and genetic polymorphisms associated with progression and survival in amyotrophic lateral sclerosis. [PDF]

, 2018
The ATP-sensitive potassium (KATP) channel directly regulates the microglia-mediated inflammatory response following CNS injury. To determine the putative role of the KATP channel in amyotrophic lateral sclerosis (ALS) pathology, we investigated whether ...
Vidal Taboada, José Manuel, Pugliese, Marco, Rodríguez Allué, Manuel José, Gamez, Josep, Mahy Gehenne, Josette Nicole, Salvado, Maria   +5 more
core   +1 more source

Investigation Of The Role Of The KATP Channel In Vascular Hyporeactivity In Sepsis [PDF]

, 2017
The lack of responsiveness of vascular smooth muscle cells (VSMCs) to vasopressor catecholamines is termed vascular hyporeactivity. Vascular hyporeactivity is an important component of sepsis.
Buckley, James Francis
core   +1 more source

Effects of extracellular K+ on grapevine membrane potential as influenced by the antiviral mycophenolic acid. An electrophysiological study

Advances in Horticultural Science, 2015
Mycophenolic acid (MPA) is an effective antiviral drug in plants, and its action in modulating the activity of KATP channels is already known in animals.
Andrea Luvisi, Enrico Rinaldelli, A. Panattoni   +2 more
doaj   +1 more source

Minoxidil and nebivolol restore aortic elastic fiber homeostasis in diabetic mice via potassium channel activation

Frontiers in Physiology
BackgroundDiabetic patients experience a significant reduction in life expectancy, primarily due to early cardiovascular complications. A key feature is the premature degradation of elastic fibers (EFs), contributing to vascular stiffness.ObjectiveThis ...
Auberi Henry, Laetitia Vanalderwiert, Floriane Oszust, Amandine Wahart, Daniel A. Carvajal Berrio, Eva M. Brauchle, Eva M. Brauchle, Katja Schenke-Layland, Katja Schenke-Layland, Katja Schenke-Layland, Juergen Brinckmann, Heiko Steenbock, Laurent Debelle, Isabelle Six, Gilles Faury, Stéphane Jaisson, Stéphane Jaisson, Philippe Gillery, Philippe Gillery, Vincent Durlarch, Vincent Durlarch, Hervé Sartelet, Pascal Maurice, Amar Bennasroune, Laurent Martiny, Laurent Duca, Béatrice Romier, Sébastien Blaise   +27 more
doaj   +1 more source

GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents

Cardiology Research and Practice, 2019
GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning ...
Qian-Feng Xiong, Shao-Hua Fan, Xue-Wen Li, Yu Niu, Jing Wang, Xin Zhang, Yi-Fan Chen, Ya-Wei Shi, Li-Hui Zhang   +8 more
doaj   +1 more source

The role of the vascular KATP channel in septic models [PDF]

, 2011
Septic shock is characterized by systemic vasodilatation and an attenuated pressor response to catecholamines. As the hyperactivity (i.e. more channels remain in the open state) of the vascular adenosine triphosphate (ATP)- sensitive type of potassium
Chan, Y.-L.
core  

Discovery and characterization of a novel KATP channel pharmacochaperone

My work resulted in the discovery of a novel KATP channel pharmacochaperone, Aekatperone, through AI-driven virtual screening of the drug binding site using the Cryo-EM structure of the KATP channel. Additionally, I functionally characterized the effects
Elsheikh, Assmaa
core   +1 more source

MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.

, 1998
ATP-sensitive potassium (KATP) channels in the pancreatic beta cell membrane mediate insulin release in response to elevation of plasma glucose levels.
Ashcroft, FM, Tucker, Stephen, Tucker, SJ, Haug, T, Gribble, FM, Ashcroft, Frances   +5 more
core   +1 more source

KATP channels in cerebral hemodynamics: a systematic review of preclinical and clinical studies

Frontiers in Neurology
Cumulative evidence suggests that ATP-sensitive potassium (KATP) channels act as a key regulator of cerebral blood flow (CBF). This implication seems to be complicated, since KATP channels are expressed in several vascular-related structures such as ...
Hassan Ali Suleiman Daoud, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi   +4 more
doaj   +1 more source