Results 91 to 100 of about 14,110 (214)

Association and Stoichiometry of KATP Channel Subunits

, 1997
ATP-sensitive potassium channels (KATP channels) are heteromultimers of sulfonylurea receptors (SUR) and inwardly rectifying potassium channel subunits (KIR6.x) with a (SUR–KIR6.x)4 stoichiometry.
Schwanstecher, Mathias, Bryan, Joseph, Clement, John P., Kunjilwar, Kumud, Aguilar-Bryan, Lydia, Gonzalez, Gabriela, Panten, Uwe   +6 more
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The role of the KATP channel in functional and reactive myocardial hyperemia [PDF]

, 1994
To evaluate the role of the KATP channel in regulating coronary tonus in response to increases in myocardial oxygen conaumption, and reactive hypermia following ischemia, coronary blood flow was measured with glibenclamide, a KATP channel blocker (50μmol/
Kobayashi, Hiroo, Hiroo KOBAYASHI
core   +1 more source

In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat

Journal of Pharmacological Sciences, 2016
The lower esophageal sphincter (LES) is a specialized region of the esophageal smooth muscle that allows the passage of a swallowed bolus into the stomach. Nitric oxide (NO) plays a major role in LES relaxation.
Tomonori Shimbo, Takeshi Adachi, Susumu Fujisawa, Mai Hongoh, Takayoshi Ohba, Kyoichi Ono   +5 more
doaj   +1 more source

Mitochondrial KATP Channels: The Facts and the Hypotheses

International Journal of Biochemistry & Physiology, 2022
The discovery of mitochondrial KATP channel (mKATP channel) in 1991 started extensive studies of its biophysical and biochemical properties, as well as cytoprotective mechanisms afforded by mKATP channels opening. However, molecular nature of mKATP channels remained undisclosed for three decades, and several hypotheses were proposed about their ...
openaire   +1 more source

The role of the vascular KATP channel in septic models [PDF]

, 2011
Septic shock is characterized by systemic vasodilatation and an attenuated pressor response to catecholamines. As the hyperactivity (i.e. more channels remain in the open state) of the vascular adenosine triphosphate (ATP)- sensitive type of potassium
Chan, Y.-L.
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Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations

, 2010
Objective: The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY).
Shield, JPH, Kapoor, RR, Hussain, K., Rubio-Cabezas, O., Kapoor, R. R., Banerjee, I, Sianhanidou, T, Siahanidou, T., Flanagan, SE, Akcay, T, Akcay, T., Cody, D., Siahanidou, T, Hussain, K, Ellard, S., Mali, G, Cody, D, Shield, JP, Shield, J. P. H., Rubio-Cabezas, O, Mali, G., Schwahn, B., Flanagan, S. E., Murphy, N, Murphy, N., Banerjee, I., Ellard, S, Schwahn, B   +27 more
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Inhibition of ATP-Sensitive K+ Channels and L-Type Ca2+ Channels by Amiodarone Elicits Contradictory Effect on Insulin Secretion in MIN6 Cells

Journal of Pharmacological Sciences, 2011
.: Some class I antiarrhythmic drugs induce a sporadic hypoglycemia by producing insulin secretion via inhibition of ATP-sensitive K+ (KATP) channels of pancreatic β-cells.
Atsushi Nishida, Taichi Takizawa, Akio Matsumoto, Takashi Miki, Susumu Seino, Haruaki Nakaya   +5 more
doaj   +1 more source

Myocardial Protection and the KATP Channel [PDF]

, 1995
1: The biology of KATP channels N.B. Standon. 2: Vascular pathology and the KATP channel U. Quast, S. Glocker. 3: Activation of the ATP-sensitive potassium channels: A novel pharmacological approach to myocardial protection? D.J. Hearse. 4: The relationship between the KATP channel and Myocardial preconditioning G.J. Gross, D.M. Yellon.
openaire   +1 more source

The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection

, 2009
The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes.
Fretwell, Laurice V, Fretwell, LV
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Investigation Of The Role Of The KATP Channel In Vascular Hyporeactivity In Sepsis [PDF]

, 2017
The lack of responsiveness of vascular smooth muscle cells (VSMCs) to vasopressor catecholamines is termed vascular hyporeactivity. Vascular hyporeactivity is an important component of sepsis.
Buckley, James Francis
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