Results 111 to 120 of about 14,110 (214)
Ectopic overexpression of Kir6.1 in the mouse heart impacts on the life expectancy
Scientific Reports, 2018 We recently reported the reduced ATP-sensitive potassium (KATP) channel activities in the transgenic mouse heart overexpressing the vascular type KATP channel pore-forming subunit (Kir6.1).
Yasuhiro Watanabe +5 more
doaj +1 more source
Effect of fenofibrate and selective PPARα modulator (SPPARMα), pemafibrate on KATP channel activity and insulin secretion. [PDF]
BMC Res Notes, 2023 Kitamura S +8 more
europepmc +1 more source
Mechanical effects on KATP channel gating in rat ventricular myocytes.
, 2013 Cardiac KATP channels link metabolism with electrical activity. They are implicated in arrhythmias, secretion of atrial natriuretic peptide and protection of the heart from hypertrophy and failure. These processes may involve mechanosensitivity.
Hua Wei +6 more
core +1 more source
, 2011 The KATP channels play an important role in the membrane excitability and vascular tone regulation. Previous studies indicate that the function of KATP channels is disrupted in oxidative stress seen in a variety of cardiovascular diseases, while the ...
Yang, Yang
core +1 more source
KATP channels in cerebral hemodynamics: a systematic review of preclinical and clinical studies
Frontiers in NeurologyCumulative evidence suggests that ATP-sensitive potassium (KATP) channels act as a key regulator of cerebral blood flow (CBF). This implication seems to be complicated, since KATP channels are expressed in several vascular-related structures such as ...
Hassan Ali Suleiman Daoud +4 more
doaj +1 more source
Mechanistic insights on KATP channel regulation from cryo-EM structures. [PDF]
J Gen Physiol, 2023 Driggers CM, Shyng SL.
europepmc +1 more source
, 2010 Pancreatic ATP-sensitive potassium (KATP) channels control insulin secretion by coupling the excitability of the pancreatic β-cell to glucose metabolism. Little is currently known about how the plasma membrane density of these channels is regulated.
Sivaprasadarao, Asipu +5 more
core +1 more source
The inhibition mechanism of the SUR2A-containing KATP channel by a regulatory helix. [PDF]
Nat Commun, 2023 Ding D, Hou T, Wei M, Wu JX, Chen L.
europepmc +1 more source
Closure by iptakalim, a cardiovascular KATP channel opener, of rat pancreatic β-cell KATP channels and its molecular basis [PDF]
application/pdfDiabetes mellitus is a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both.
Wu, Jie +5 more
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