Results 101 to 110 of about 14,110 (214)

MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.

, 1998
ATP-sensitive potassium (KATP) channels in the pancreatic beta cell membrane mediate insulin release in response to elevation of plasma glucose levels.
Ashcroft, FM, Tucker, Stephen, Tucker, SJ, Haug, T, Gribble, FM, Ashcroft, Frances   +5 more
core   +1 more source

KATP channel controls LPS-induced MUC5AC overexpression in vivo

, 2020
Glybenclamide; Hypersecretion; Inflammation; KATP channel; MUC5AC ...
송경섭
core  

Effects of extracellular K+ on grapevine membrane potential as influenced by the antiviral mycophenolic acid. An electrophysiological study

Advances in Horticultural Science, 2015
Mycophenolic acid (MPA) is an effective antiviral drug in plants, and its action in modulating the activity of KATP channels is already known in animals.
Andrea Luvisi, Enrico Rinaldelli, A. Panattoni   +2 more
doaj   +1 more source

Effects of U-37883A, a vascular selective KATP+ channel antagonist, in the pulmonary and hindlimb circulation

, 1996
The effects of the vascular selective nonsulfonylurea guanidine ATP-sensitive K+ (KATP+) channel-blocking agent U-37883A on vasodilator and vasoconstrictor responses were investigated in the pulmonary and hindlimb vascular beds of the cat.
B. J. DeWitt, T. J. McMahon, J. R. Marrone, P. J. Kandowitz, D. Y. Cheng, H. C. Champion   +5 more
core   +1 more source

Discovery and characterization of a novel KATP channel pharmacochaperone

My work resulted in the discovery of a novel KATP channel pharmacochaperone, Aekatperone, through AI-driven virtual screening of the drug binding site using the Cryo-EM structure of the KATP channel. Additionally, I functionally characterized the effects
Elsheikh, Assmaa
core   +1 more source

Minoxidil and nebivolol restore aortic elastic fiber homeostasis in diabetic mice via potassium channel activation

Frontiers in Physiology
BackgroundDiabetic patients experience a significant reduction in life expectancy, primarily due to early cardiovascular complications. A key feature is the premature degradation of elastic fibers (EFs), contributing to vascular stiffness.ObjectiveThis ...
Auberi Henry, Laetitia Vanalderwiert, Floriane Oszust, Amandine Wahart, Daniel A. Carvajal Berrio, Eva M. Brauchle, Eva M. Brauchle, Katja Schenke-Layland, Katja Schenke-Layland, Katja Schenke-Layland, Juergen Brinckmann, Heiko Steenbock, Laurent Debelle, Isabelle Six, Gilles Faury, Stéphane Jaisson, Stéphane Jaisson, Philippe Gillery, Philippe Gillery, Vincent Durlarch, Vincent Durlarch, Hervé Sartelet, Pascal Maurice, Amar Bennasroune, Laurent Martiny, Laurent Duca, Béatrice Romier, Sébastien Blaise   +27 more
doaj   +1 more source

The ATP-sensitive K+-channel (KATP) controls early left–right patterning in Xenopus and chick embryos

, 2010
Consistent left–right asymmetry requires specific ion currents. We characterize a novel laterality determinant in Xenopus laevis: the ATP-sensitive K+-channel (KATP).
Wade Pearson, Michael Levin, Aw, Sherry, Colin G. Nichols, Shi, Nian-Qing, Sherry Aw, Nian-Qing Shi, Nichols, Colin G., Levin, Michael, Carneiro, Katia, Joseph C. Koster, Pearson, Wade, Katia Carneiro, Koster, Joseph C.   +13 more
core   +1 more source

GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents

Cardiology Research and Practice, 2019
GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning ...
Qian-Feng Xiong, Shao-Hua Fan, Xue-Wen Li, Yu Niu, Jing Wang, Xin Zhang, Yi-Fan Chen, Ya-Wei Shi, Li-Hui Zhang   +8 more
doaj   +1 more source

Regulation of Myoplasmic Ca2+ During Fatigue in KATP Channel Deficient FDB Muscle Fibres

, 2013
It is known that muscles that lack KATP channel activity generate much greater unstimulated [Ca2+]i and force than normal muscles during fatigue. The increase in unstimulated force in KATP channel deficient muscles is abolished by a partial inhibition of
Selvin, David
core   +2 more sources

KATP-Channel-Dependent Regulation of Catecholaminergic Neurons Controls BAT Sympathetic Nerve Activity and Energy Homeostasis

, 2013
SummaryBrown adipose tissue (BAT) is a critical regulator of glucose, lipid, and energy homeostasis, and its activity is tightly controlled by the sympathetic nervous system.
Lars Paeger, Evers, Nadine, A. Christine Hausen, Sulay Tovar, Hampel, Brigitte, Hausen, A., Ackermann, P., Evers, N., Brönneke, Hella S., Tovar, S., Hampel, B., Hildegard Büning, Kamal Rahmouni, Morgan, D., Kloppenburg, P., Büning, Hildegard, Wunderlich, F. Thomas, Wunderlich, F., Rahmouni, K., P. Justus Ackermann, Morgan, Donald A., Donald A. Morgan, Nadine Evers, Peter Kloppenburg, Ackermann, P. Justus, F. Thomas Wunderlich, Hess, Simon, Brüning, Jens C., Hella S. Brönneke, Simon Hess, Paeger, Lars, Rahmouni, Kamal, Brigitte Hampel, Brüning, J., Tovar, Sulay, Paeger, L., Hausen, A. Christine, Büning, H., Jens C. Brüning, Hess, S., Brönneke, H., Kloppenburg, Peter   +41 more
core   +1 more source