Results 61 to 70 of about 1,219,583 (164)
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi +7 more
wiley +1 more source
The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection [PDF]
, 2009 The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes.
Fretwell, Laurice V, Fretwell, LV
core
Pharmacogenomics and Personalized Medicine, 2010 Veronica Lang, Peter E LightDepartment of Pharmacology and Alberta Diabetes Institute, Faculty of Medicine and Dentistry, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta, CanadaAbstract: Neonatal diabetes mellitus (NDM)
Veronica Lang, Peter E Light
doaj
BRET‐Based Approaches for Ion Channels: Emerging Applications and Future Directions
Archiv der Pharmazie, Volume 359, Issue 9, September 2026.Bioluminescence resonance energy transfer (BRET) is a versatile method for studying ligand–protein interactions. Its compatibility with high‐throughput screening and real‐time kinetics has made it widely used in drug discovery. Here, we summarize recent applications of BRET‐based methods for studying ligand binding to ion channels, highlighting key ...
Nadine Kock +6 more
wiley +1 more source
Ecography, Volume 2026, Issue 9, September 2026.The Pan‐Himalayan region harbors exceptional biodiversity, yet the origins and underlying mechanisms driving this remarkable diversity remain poorly understood, especially among species‐rich invertebrates. Pimoa spiders exhibit an intercontinental disjunct distribution across three major mountain regions: the Rockies, the Alps, and the Pan‐Himalaya ...
Xiaoqing Zhang +9 more
wiley +1 more source
Frontiers in PhysiologyATP-sensitive potassium (KATP) channels link beta-cell metabolism to electrical activity. By modulating the beta-cell membrane potential, they finely regulate glucose-stimulated insulin secretion.
Natascia Vedovato +5 more
doaj +1 more source
BAD and KATP channels regulate neuron excitability and epileptiform activity
eLife, 2018 Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures ...
Juan Ramón Martínez-François +6 more
doaj +1 more source
Health Science Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation,
Nawfal Hasan Siam +8 more
wiley +1 more source
Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]
, 2003 The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Quinn, KV +4 more
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Association and Stoichiometry of KATP Channel Subunits [PDF]
, 1997 ATP-sensitive potassium channels (KATP channels) are heteromultimers of sulfonylurea receptors (SUR) and inwardly rectifying potassium channel subunits (KIR6.x) with a (SUR–KIR6.x)4 stoichiometry.
Schwanstecher, Mathias +6 more
core +1 more source