GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase [PDF]
, 2017 This is the final version of the article. Available from the publisher via the DOI in this record.There is another ORE record for this publication: http://hdl.handle.net/10871/33406The K+-Cl-co-transporter KCC2 (SLC12A5) tunes the efficacy of ...
Al Awabdh, S +11 more
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Bumetanide Treatment in 15 Children With Autism: A Randomised Waitlist‐Control Study
Acta Paediatrica, Volume 114, Issue 11, Page 2985-2992, November 2025.ABSTRACT Aim Bumetanide, a diuretic, influences neuronal chloride homeostasis and potentially restores GABAergic inhibition and neuronal signalling balance. This mechanism may contribute to improvements in autism‐related symptoms. The present study builds on the preclinical research and on previous clinical research on bumetanide treatment for children
Elisabeth Fernell +7 more
wiley +1 more source
Beyond ion transport: KCC2 makes cells walk and talk [PDF]
The Journal of Physiology, 2011 Tumour cells often express a repertoire of genes unusual for the cell lineage from which they originate. It is not surprising that these genes include ion channels and transporters, but because biophysicists are rarely interested in cancer biology, and scientists working on cancer often shy away from ion transport physiology, specific functions of ...
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Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain [PDF]
, 2015 Peer ...
Jovanov-Milošević, Natasa +6 more
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Epilepsia, Volume 66, Issue 11, Page 4139-4161, November 2025.Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire +9 more
wiley +1 more source
KCC2 Much Chloride Might Not Be the Only Problem [PDF]
Epilepsy Currents, 2019 [Box: see text]
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Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons [PDF]
, 2014 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease manifested by progressive muscle atrophy and paralysis due to the loss of upper and lower motoneurons (MN).
Alé, Albert +4 more
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WNK1/HSN2 isoform and the regulation of KCC2 activity [PDF]
Rare Diseases, 2013 Hereditary sensory and autonomic neuropathy type 2 is a rare autosomal recessive pathology presenting with early onset peripheral sensory defects. It arises from mutations affecting a specific isoform of the WNK1 kinase (with-no-lysine protein kinase 1) termed WNK1/HSN2. The role of WNK1 in the nervous system is not well understood. In our recent paper,
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Levels of Ca\u3csub\u3ev\u3c/sub\u3e1.2 L-Type Ca\u3csup\u3e2+\u3c/sup\u3e Channels Peak in the First Two Weeks in Rat Hippocampus Whereas Ca\u3csub\u3ev\u3c/sub\u3e1.3 Channels Steadily Increase through Development [PDF]
, 2012 Influx of calcium through voltage-dependent channels regulates processes throughout the nervous system. Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly modulated by G-protein-coupled ...
Ingraham, Nicholas E. +3 more
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Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction
Brain Research, 2019 SLC12A5 encodes K+-Cl- cotransporter 2 (KCC2), which is the main Cl- extruder of neurons, and renders the proper inhibitory function of the neurotransmitters γ-aminobutyric acid (GABA) and glycine. Thus, any variant in SLC12A5, if it causes dysfunction of KCC2, could be pathogenic for neurological and psychiatric disorders by disrupting inhibition and ...
Atsuo Fukuda, Miho Watanabe
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