Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures [PDF]
, 2014 Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults.
Delpire E +7 more
core +1 more source
Epilepsy of Infancy With Migrating Focal Seizures
Annals of the Child Neurology Society, EarlyView.
Samuel Kamoroff +2 more
wiley +1 more source
Mechanisms of comorbidity between Alzheimer's disease and pain
Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.ABSTRACT Clinical studies have revealed a significant correlation between pain and neurodegenerative diseases, particularly Alzheimer's disease (AD). However, due to cognitive and speech impairments, AD patients, especially those in moderate to severe stages, are often overlooked in pain management.
Kaifang Yao +12 more
wiley +1 more source
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes
Cell Reports, 2019 Summary: The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling. This raises questions about whether neural processing is comparably altered. Here, we test whether the K+-Cl−
Josiane C.S. Mapplebeck +7 more
doaj
Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology
Developmental Dynamics, Volume 254, Issue 2, Page 102-141, February 2025.Abstract The ventral body wall (VBW) that encloses the thoracic and abdominal cavities arises by extensive cell movements and morphogenetic changes during embryonic development. These morphogenetic processes include embryonic folding generating the primary body wall; the initial ventral cover of the embryo, followed by directed mesodermal cell ...
Caroline Formstone +3 more
wiley +1 more source
An Ion Transport-Independent Role for the Cation-Chloride Cotransporter KCC2 in Dendritic Spinogenesis In Vivo [PDF]
, 2017 The neuron-specific K-Cl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in pyramidal neurons, and recent in vitro data suggest that this protein plays a role in the development of dendritic spines.
Belem, Bebyanda JT +8 more
core
Role of cholesterol in modulating brain hyperexcitability
Epilepsia, Volume 66, Issue 1, Page 33-46, January 2025.Abstract Cholesterol is a critical molecule in the central nervous system, and imbalances in the synthesis and metabolism of brain cholesterol can result in a range of pathologies, including those related to hyperexcitability. The impact of cholesterol on disorders of epilepsy and developmental and epileptic encephalopathies is an area of growing ...
James W. Wheless, Jong M. Rho
wiley +1 more source
Levels of Ca\u3csub\u3ev\u3c/sub\u3e1.2 L-Type Ca\u3csup\u3e2+\u3c/sup\u3e Channels Peak in the First Two Weeks in Rat Hippocampus Whereas Ca\u3csub\u3ev\u3c/sub\u3e1.3 Channels Steadily Increase through Development [PDF]
, 2012 Influx of calcium through voltage-dependent channels regulates processes throughout the nervous system. Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly modulated by G-protein-coupled ...
Ingraham, Nicholas E. +3 more
core +1 more source
Vasopressin excites interneurons to suppress hippocampal network activity across a broad span of brain maturity at birth [PDF]
, 2017 During birth in mammals, a pronounced surge of fetal peripheral stress hormones takes place to promote survival in the transition to the extrauterine environment.
Crow, Ailey K. +13 more
core +1 more source
Molecular Oncology, Volume 18, Issue 12, Page 2951-2965, December 2024.Animal modeling based on data from studies on humans aims to recapitulate primary developmental brain tumor features and serve as a tool to study the pathogenesis of epilepsy‐associated tumor processes, particularly tumor progression and neuronal hyperexcitability. Thus, understanding the interaction between brain tumor cells and neurons is critical to
Silvia Cases‐Cunillera +4 more
wiley +1 more source