Results 111 to 120 of about 4,475 (201)

The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl− extrusion

iScience
Summary: LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is ...
Noell Cho, Georgina Kontou, Joshua L. Smalley, Christopher Bope, Jacob Dengler, Kristopher Montrose, Tarek Z. Deeb, Nicholas J. Brandon, Tadashi Yamamoto, Paul A. Davies, Georgios Giamas, Stephen J. Moss   +11 more
doaj  

Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development [PDF]

, 2022
Donghang Zhang, Yujiao Yang, Yaoxin Yang, Jin Liu, Tao Zhu, Han Huang, Cheng Zhou   +6 more
openalex   +1 more source

BDNF Signaling Promotes Vestibular Compensation by Increasing Neurogenesis and Remodeling the Expression of Potassium-Chloride Cotransporter KCC2 and GABA_AReceptor in the Vestibular Nuclei [PDF]

, 2016
Sophie Dutheil, Isabelle Watabe, Karina Sadlaoud, Alain Tonetto, Brahim Tighilet   +4 more
openalex   +1 more source

Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory [PDF]

, 2022
Caroline Fasano, Jill Rocchetti, Katarzyna Pietrajtis, Johannes-Friedrich Zander, Frédéric Manseau, Diana Sakae, Maya Marcus-Sells, Lauriane Ramet, Lydie Morel, Damien Carrel, Sylvie Dumas, Susanne Bolte, Véronique Bernard, Érika Vigneault, Romain Goutagny, Gudrun Ahnert‐Hilger, Bruno Giros, Stéphanie Daumas, Sylvain Williams, Salah El Mestikawy   +19 more
openalex   +1 more source

Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain

Cell Reports, 2016
Summary: Chronic neuropathic pain is a debilitating condition that remains difficult to treat. Diminished synaptic inhibition by GABA and glycine and increased NMDA receptor (NMDAR) activity in the spinal dorsal horn are key mechanisms underlying ...
Lingyong Li, Shao-Rui Chen, Hong Chen, Lei Wen, Walter N. Hittelman, Jing-Dun Xie, Hui-Lin Pan   +6 more
doaj  

KCC2 downregulation after sciatic nerve injury enhances motor function recovery [PDF]

, 2022
Dennis Lawrence Cheung, Takuya Toda, Madoka Narushima, Kei Eto, Chitoshi Takayama, Tatsuko Ooba, Hiroaki Wake, Andrew J. Moorhouse, Junichi Nabekura   +8 more
openalex   +1 more source

Ketogenic Diet Provided During Three Months Increases KCC2 Expression but Not NKCC1 in the Rat Dentate Gyrus [PDF]

, 2020
Leticia Granados-Rojas, Karina Jerónimo-Cruz, Tarsila Elizabeth Juárez-Zepeda, Miguel Tapia‐Rodríguez, Armando R. Tovar, Rodolfo Rodríguez‐Jurado, Liliana Carmona‐Aparicio, Noemí Cárdenas‐Rodríguez, Elvia Coballase-Urrutía, Matilde Ruiz García, Pilar Durán   +10 more
openalex   +1 more source

Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF [PDF]

, 2023
Paula M. Calvo, Rosa R. de la Cruz, Ángel M. Pastor, Francisco J. Álvarez   +3 more
openalex   +1 more source

Inflammation alters cation chloride cotransporter expression in sensory neurons

Neurobiology of Disease, 2004
Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporter is ...
Begonia M. Morales-Aza, Naomi L. Chillingworth, John A. Payne, Lucy F. Donaldson   +3 more
doaj  

Neuronal Potassium-Chloride co-transporter KCC2 regulates the formation of hippocampal circuits in- utero.

, 2010
Medina Igor
openalex   +1 more source