Generation and Characterization of the Cation-Chloride Cotransporter KCC2 Hypomorphic Mouse [PDF]
, 2006 The cation-Cl- cotransporter (CCC) family comprises of Na+-Cl- cotransporter (NCC), Na+-K+-2Cl- cotransporters (NKCC1-2), and four K+-Cl- cotransporters (KCC1-4).
Tornberg, Janne
core
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics. [PDF]
, 2017 Individuals with 22q11.2 microdeletion syndrome (22q11.2 DS) show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing schizophrenia and autism.
Amin, Hayder +3 more
core +2 more sources
Alzheimer's &Dementia, Volume 20, Issue 10, Page 7369-7383, October 2024.Abstract Neurogenesis persists throughout adulthood in the hippocampus and contributes to specific cognitive functions. In Alzheimer's disease (AD), the hippocampus is affected by pathology and functional impairment early in the disease. Human AD patients have reduced adult hippocampal neurogenesis (AHN) levels compared to age‐matched healthy controls.
Joris N. Geigenmüller +3 more
wiley +1 more source
Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures
Frontiers in Cellular Neuroscience, 2015 Neto2 is a transmembrane protein that interacts with the neuron-specific K+-Cl- cotransporter (KCC2) in the CNS. Efficient KCC2 transport is essential for setting the neuronal Cl- gradient, which is required for fast GABAergic inhibition.
Vivek eMahadevan +12 more
doaj +1 more source
Hippocampe et épilepsie : données issues des tissus humains [PDF]
, 2015 International audienceSurgical removal of the epileptogenic zone provides an effective therapy for several focal epileptic syndromes. This surgery offers the opportunity to study pathological activity in living human tissue for pharmacoresistant partial ...
Blauwblomme, Thomas +2 more
core +4 more sources
KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels
Cell Reports, 2019 Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders.
Marie Goutierre +7 more
doaj
Symptomatic seizures in preterm newborns: a review on clinical features and prognosis [PDF]
, 2018 Neonatal seizures are the most common neurological event in newborns, showing higher prevalence in preterm than in full-term infants. In the majority of cases they represent acute symptomatic phenomena, the main etiologies being intraventricular ...
Corsello G +4 more
core +2 more sources
Cell Reports, 2019 Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust
Inkeri Spoljaric +5 more
doaj
Gamma oscillatory activity in vitro: a model system to assess pathophysiological mechanisms of comorbidity between autism and epilepsy. [PDF]
, 2018 Autism spectrum disorder (ASD) and temporal lobe epilepsy exhibit remarkable comorbidity, but for reasons not clearly understood. To reveal a common pathophysiological mechanism, we here describe and characterize an in vitro epileptiform activity in the ...
Babu, K.S. +5 more
core +2 more sources
Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2
Frontiers in Cellular Neuroscience, 2014 In the mammalian central nervous system, the inhibitory strength of chloride (Cl-)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl- concentration ([Cl-]i).
Igor eMedina +13 more
doaj +1 more source