Results 31 to 40 of about 1,940 (148)

A Network Pharmacology and Experimental Validation Strategy for Hypoglycemic Study of Lonicerae Japonicae Flos on Diabetes. [PDF]

J Cell Mol Med
ABSTRACT As diabetes has become an important public health issue, Lonicerae Japonicae Flos (LJF) had gradually attracted increasing attention on diabetes. This study aimed to investigate the hypoglycemic ingredients and underlying mechanisms of LJF in diabetes using an integrated strategy of network pharmacology, molecular docking and experimental ...
Nan Z, Xiaolong L, Chunyan L, Lu R, Chao G, Jintao X.   +5 more
europepmc   +2 more sources

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice

JCI Insight, 2021
Cantu syndrome (CS) is caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunits, the most common mutations being SUR2[R1154Q] and SUR2[R1154W], carried by ...
Haixia Zhang, Alex Hanson, Tobias Scherf de Almeida, Christopher Emfinger, Conor McClenaghan, Theresa Harter, Zihan Yan, Paige E. Cooper, G. Schuyler Brown, Eric C. Arakel, Robert P. Mecham, Atilla Kovacs, Carmen M. Halabi, Blanche Schwappach, Maria S. Remedi, Colin G. Nichols   +15 more
doaj   +1 more source

Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome

Frontiers in Pharmacology, 2020
Cantù syndrome (CS) arises from mutations in ABCC9 and KCNJ8 genes that lead to gain of function (GOF) of ATP-sensitive potassium (KATP) channels containing SUR2A and Kir6.1 subunits, respectively, of KATP channels.
Rosa Scala, Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Giulia Maria Camerino, Francesco Alfredo Zito, Girolamo Ranieri, Conor McClenaghan, Theresa M. Harter, Colin G. Nichols, Domenico Tricarico   +10 more
doaj   +1 more source

Glycosylation-Associated Macrophage Signatures Define a Diagnostic Model for Diabetic Retinopathy via Single-Cell Analysis. [PDF]

J Ophthalmol
Purpose Diabetic retinopathy (DR) remains a leading cause of vision loss, with macrophages and glycosylation dysregulation implicated in DR pathogenesis. However, the potential as diagnostic biomarkers has been rarely investigated. Methods We integrated single‐cell RNA sequencing (scRNA‐seq) datasets to profile DR cell landscapes.
Pan Z, Zhou S, Qi W, Wang J, Luo Y, Fan F.   +5 more
europepmc   +2 more sources

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

Disease Models & Mechanisms, 2018
The zebrafish (Danio rerio) has become a popular vertebrate model organism to study organ formation and function due to its optical clarity and rapid embryonic development.
Federico Tessadori, Helen I. Roessler, Sanne M. C. Savelberg, Sonja Chocron, Sarah M. Kamel, Karen J. Duran, Mieke M. van Haelst, Gijs van Haaften, Jeroen Bakkers   +8 more
doaj   +1 more source

Table1_Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug–disease interactions.DOCX

, 2023
Background: ATP-sensitive-K+ channels (KATP) are involved in diseases, but their role in cancer is poorly described. Pituitary macroadenoma has been observed in Cantu’ syndrome (C.S.), which is associated with the gain-of-function mutations of the ABCC9 ...
Domenico Tricarico (316527), Marcella Attimonelli (73528), Antonella Tinelli (15350632), Nicola Zizzo (351289), Girolamo Ranieri (289106), Marina Antonacci (15350635), Fatima Maqoud (15350629), Giuseppe Passantino (6736829)   +7 more
core   +1 more source

Functional Consequences of Cantu Syndrome Associated Mutations in the ATP Sensitive Potassium Channel [PDF]

, 2015
ATP-sensitive potassium (KATP) channels are composed of inward-rectifying potassium channel pore-forming subunits (Kir6.1 and Kir6.2, encoded by KCNJ8 and KCNJ11, respectively) and regulatory sulfonylurea receptor subunits (SUR1 and SUR2, encoded by ...
Cooper, Paige
core   +1 more source

In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat

Journal of Pharmacological Sciences, 2016
The lower esophageal sphincter (LES) is a specialized region of the esophageal smooth muscle that allows the passage of a swallowed bolus into the stomach. Nitric oxide (NO) plays a major role in LES relaxation.
Tomonori Shimbo, Takeshi Adachi, Susumu Fujisawa, Mai Hongoh, Takayoshi Ohba, Kyoichi Ono   +5 more
doaj   +1 more source

ATP sensitive potassium channels in the skeletal muscle functions : involvement of the KCNJ11(Kir6.2) gene in the determination of Warner Bratzer shear force

Frontiers in Physiology, 2016
The ATP-sensitive K+-channels (KATP) are distributed in the tissues coupling metabolism with K+ ions efflux. KATP subunits are encoded by KCNJ8 (Kir6.1), KCNJ11 (Kir6.2), ABCC8 (SUR1) and ABCC9 (SUR2) genes, alternative RNA splicing give rise to SUR ...
Domenico eTricarico, Maria eSelvaggi, Giuseppe ePassantino, Pasquale eDe Palo, Dario eCataldo, Pasquale eCentoducati, Alessandra eTateo, Angela eCurci, Fatima eMaquod, Antonietta eMele, Giulia Maria eCamerino, Antonella eLiantonio, Paola eImbrici, Nicola eZizzo   +13 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source