Results 41 to 50 of about 217 (107)

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

A genome wide association study for the number of animals born dead in domestic pigs

BMC Genetics, 2019
Background The number of animals born dead, which includes the number of mummified (NM) and stillborn (NS) animals, is the most important trait to directly quantify the reproductive loss in domestic pigs.
Pingxian Wu, Kai Wang, Jie Zhou, Qiang Yang, Xidi Yang, Anan Jiang, Yanzhi Jiang, Mingzhou Li, Li Zhu, Lin Bai, Xuewei Li, Guoqing Tang   +11 more
doaj   +1 more source

Multi‐Omics Insights Into the Role of Fructooligosaccharides Supplementation in Alleviating Salpingitis in Laying Hens

Animal Research and One Health, Volume 4, Issue 1, Page 105-119, February 2026.
Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song, Tao Duan, Rong Li, Xiaoqiu Wang, Fengdong Zhang, Jia Feng, Lin Qiao, Junlin Cheng, Lixian Chen, Aike Li, Yuna Min, Weiwei Wang   +11 more
wiley   +1 more source

Contemporary Perspectives on J‐Wave Syndromes: An Expert Consensus Statement

Journal of Arrhythmia, Volume 42, Issue 1, February 2026.
ABSTRACT J‐wave syndromes (JWS)—comprising Brugada syndrome (BrS) and early repolarization syndrome (ERS)—are important causes of malignant ventricular arrhythmias and sudden cardiac death in patients whose hearts appear structurally normal. Since the 2016 consensus, advances in genetics, pathophysiology, and therapy have redefined both understanding ...
Koonlawee Nademanee, Arthur A. Wilde, Michael J. Ackerman, Elijah R. Behr, Connie R. Bezzina, Peng‐Sheng Chen, Fa Po Chung, Ruben Coronel, Michel Haissaguerre, Chenyang Jiang, Jyh‐Ming Jimmy Juang, Apichai Khongphatthanayothin, Naomasa Makita, Hiroshi Morita, Hiroshi Nakagawa, Tachapong Ngarmukos, Akihiko Nogami, Carlo Pappone, Silvia G. Priori, Raphael Rosso, Wataru Shimizu, Gumpanart Veerakul, Sami Viskin   +22 more
wiley   +1 more source

Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus

Glia, Volume 74, Issue 1, January 2026.
In Vrk2‐deficient mice, tonic GABA inhibition is reduced in the mediodorsal thalamus due to impaired astrocytic GABA synthesis. Microglial VRK2 regulates this process via TNF‐α signaling, revealing a glial–glial mechanism of thalamic inhibition.
Dongsu Lee, Go Eun Ha, Yeleen Lee, Denise Lee, Jongseo Lee, Jae Ho Yoon, Leechung Chang, Kyung Won Jo, Ho‐Keun Kwon, Kyong‐Tai Kim, Eunji Cheong   +10 more
wiley   +1 more source

Changes in the expression of molecular genetic regulators of the functional state of endocrine cells in SHR rats

Journal of Education, Health and Sport
Essential arterial hypertension is accompanied by chronic vascular and neurohumoral stress and microcirculatory disturbances that can alter the functional state of the endocrine compartment of the pancreas and promote its remodelling.
T. Ivanenko
doaj   +1 more source

Successful Isoproterenol Treatment for Ventricular Fibrillation Storm in Early Repolarization Syndrome With SCN5A Mutation

Annals of Noninvasive Electrocardiology, Volume 31, Issue 1, January 2026.
Suppression of VF storm in ERS with SCN5A mutation using isoproterenol. ABSTRACT A 58‐year‐old man experienced a ventricular fibrillation storm with prominent inferolateral J waves and was diagnosed with early repolarization syndrome. Initial coronary angiography showed no significant stenosis and the other evaluations for ventricular fibrillation were
Sung Soo Kim, Jeong Tae Byoun, Donghyeon Joo, Jum Suk Ko, Nam Ho Kim, Hyung Ki Jeong   +5 more
wiley   +1 more source

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source

Functional Consequences of Cantu Syndrome Associated Mutations in the ATP Sensitive Potassium Channel

, 2015
ATP-sensitive potassium (KATP) channels are composed of inward-rectifying potassium channel pore-forming subunits (Kir6.1 and Kir6.2, encoded by KCNJ8 and KCNJ11, respectively) and regulatory sulfonylurea receptor subunits (SUR1 and SUR2, encoded by ...
Cooper, Paige
core   +1 more source

Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity

, 2020
Cantu syndrome (CS) is a complex disorder caused by gain-of-function (GoF) mutations in ABCC9 and KCNJ8, which encode the SUR2 and Kir6.1 subunits, respectively, of vascular smooth muscle (VSM) KATP channels.
Remedi, Maria S, Chalk, Rod, Nichols, Colin G, Yan, Zihan, van Haaften, Gijs, Halabi, Carmen M, Kovacs, Attila, Huang, Yan, Harter, Theresa M, McClenaghan, Conor   +9 more
core   +2 more sources