Results 51 to 60 of about 217 (107)
Advanced Science, Volume 12, Issue 47, December 18, 2025.A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu +14 more
wiley +1 more source
Functional network analysis of cardiac ion channel genes using IPA.
, 2013 A. First network including SCN2B, KCNJ5, KCNJ8 and CACNB2 genes (network score = 11). B. Second network with CLIC2 gene (network score = 3). Color intensity is correlated with fold change, green means downregulation and red overexpression. Straight lines
Luis Martínez-Dolz (331425) +12 more
core +1 more source
Frontiers in MedicineIntroductionCantú syndrome (CS) is a rare genetic disorder caused by gain-of-function (GOF) mutations in the KCNJ8 (Kir6.1) or ABCC9 (SUR2) subunits of ATP-sensitive potassium (KATP) channels.
Fatima Maqoud +10 more
doaj +1 more source
Journal of Arrhythmia, Volume 41, Issue 6, December 2025.Mendelian randomization analyses suggest that genetic proxies for antidiabetic drug targets—KCNJ11/ABCC8, SLC5A2, and RXRB—reduce the risk of paroxysmal tachycardia (PT), right bundle branch block (RBBB), and atrial fibrillation (AF), respectively.
Zheng‐Qi Song +7 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Advanced Science, Volume 12, Issue 41, November 6, 2025.Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser +11 more
wiley +1 more source
The FASEB Journal, Volume 39, Issue 16, 31 August 2025.This study represents the first scRNA‐seq investigation revealing cellular heterogeneity during the hyperacute (3 h), acute (2 days), and subacute (7 days) phases of neonatal hypoxic–ischemic encephalopathy (HIE). ABSTRACT Neonatal hypoxic–ischemic encephalopathy (HIE) is a severe neurological condition associated with high rates of mortality or long ...
Xianbo Chen, Xiaohong Tao, Jingyu Wang
wiley +1 more source
Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry [PDF]
, 2019 Cantú syndrome (CS), first described in 1982, is caused by pathogenic variants in ABCC9 and KCNJ8, which encode the regulatory and pore forming subunits of ATP-sensitive potassium (KATP) channels, respectively.
Nine V. A. M. Knoers +31 more
core +1 more source
Towards the treatment of Cantú syndrome. Drug repurposing for rare genetic diseases
, 2021 Individually, rare genetic diseases affect a small number of individuals. However, collectively they represent an important public health burden by impacting 8% of the EU population.
Roessler, Helen Isabel
core +1 more source
Journal of Arrhythmia, Volume 41, Issue 4, August 2025.Notched P‐waves on 12‐lead ECG are significantly associated with ventricular fibrillation in Brugada syndrome, suggesting their potential relevance in identifying patients at increased arrhythmic risk. ABSTRACT Background Risk stratification for ventricular fibrillation (VF) in patients with Brugada syndrome (BrS) remains a significant clinical ...
Keisuke Yonezu +12 more
wiley +1 more source