Results 51 to 60 of about 1,940 (148)

Potassium channel Kir6.1 is associated with the progression of hereditary multiple osteochondromas

, 2022
Multiple osteochondromas (MO) are benign cartilage-capped tumors believed to originate from the perichondrium of long bones. The most severe complication of MO is malignant transformation of an osteochondroma into a radiation-resistant secondary ...
Streicher, Anna
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Towards the treatment of Cantú syndrome. Drug repurposing for rare genetic diseases [PDF]

, 2021
Individually, rare genetic diseases affect a small number of individuals. However, collectively they represent an important public health burden by impacting 8% of the EU population.
Roessler, Helen Isabel
core   +1 more source

Changes in the expression of molecular genetic regulators of the functional state of endocrine cells in SHR rats

Journal of Education, Health and Sport
Essential arterial hypertension is accompanied by chronic vascular and neurohumoral stress and microcirculatory disturbances that can alter the functional state of the endocrine compartment of the pancreas and promote its remodelling.
T. Ivanenko
doaj   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Multi‐Omics Insights Into the Role of Fructooligosaccharides Supplementation in Alleviating Salpingitis in Laying Hens

Animal Research and One Health, Volume 4, Issue 1, Page 105-119, February 2026.
Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song, Tao Duan, Rong Li, Xiaoqiu Wang, Fengdong Zhang, Jia Feng, Lin Qiao, Junlin Cheng, Lixian Chen, Aike Li, Yuna Min, Weiwei Wang   +11 more
wiley   +1 more source

Contemporary Perspectives on J‐Wave Syndromes: An Expert Consensus Statement

Journal of Arrhythmia, Volume 42, Issue 1, February 2026.
ABSTRACT J‐wave syndromes (JWS)—comprising Brugada syndrome (BrS) and early repolarization syndrome (ERS)—are important causes of malignant ventricular arrhythmias and sudden cardiac death in patients whose hearts appear structurally normal. Since the 2016 consensus, advances in genetics, pathophysiology, and therapy have redefined both understanding ...
Koonlawee Nademanee, Arthur A. Wilde, Michael J. Ackerman, Elijah R. Behr, Connie R. Bezzina, Peng‐Sheng Chen, Fa Po Chung, Ruben Coronel, Michel Haissaguerre, Chenyang Jiang, Jyh‐Ming Jimmy Juang, Apichai Khongphatthanayothin, Naomasa Makita, Hiroshi Morita, Hiroshi Nakagawa, Tachapong Ngarmukos, Akihiko Nogami, Carlo Pappone, Silvia G. Priori, Raphael Rosso, Wataru Shimizu, Gumpanart Veerakul, Sami Viskin   +22 more
wiley   +1 more source

Ефекти глутатіону на експресію АТФ-чутливих калієвих каналів, мітохондріальну пору і окисний стрес у серці старих щурів [PDF]

, 2020
Ефекти глутатіону на експресію АТФ-чутливих калієвих каналів, мітохондріальну пору і окисний стрес у серці старих щурів / Н. А. Струтинська та ін. Фізіологічний журнал. 2020. Т.
Струтинська Н. А., Мись Л. А., Коркач Ю. П., Сагач В. Ф., Лучкова А. Ю, Гошовська Ю. В., Струтинський Р. Б.   +6 more
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Microglial VRK2 Regulates Astrocytic GABA Synthesis and Tonic Inhibition in the Thalamus

Glia, Volume 74, Issue 1, January 2026.
In Vrk2‐deficient mice, tonic GABA inhibition is reduced in the mediodorsal thalamus due to impaired astrocytic GABA synthesis. Microglial VRK2 regulates this process via TNF‐α signaling, revealing a glial–glial mechanism of thalamic inhibition.
Dongsu Lee, Go Eun Ha, Yeleen Lee, Denise Lee, Jongseo Lee, Jae Ho Yoon, Leechung Chang, Kyung Won Jo, Ho‐Keun Kwon, Kyong‐Tai Kim, Eunji Cheong   +10 more
wiley   +1 more source

Functional network analysis of cardiac ion channel genes using IPA.

, 2013
A. First network including SCN2B, KCNJ5, KCNJ8 and CACNB2 genes (network score = 11). B. Second network with CLIC2 gene (network score = 3). Color intensity is correlated with fold change, green means downregulation and red overexpression. Straight lines
Luis Martínez-Dolz (331425), José Anastasio Montero (299175), Ana Ortega (493347), Estefanía Tarazón (299168), Miguel Rivera (299169), Manuel Portolés (299177), Manuel Otero (493348), Francisca Lago (293475), José Ramón González-Juanatey (239790), Francisco España (299173), Esther Roselló-Lletí (299170), Pablo García-Pavía (493349), Maria Micaela Molina-Navarro (299171)   +12 more
core   +1 more source

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source