Results 61 to 70 of about 1,940 (148)

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

Advanced Science, Volume 12, Issue 47, December 18, 2025.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu, Qinqin Xie, Xiaodian Cai, Zhanming Zhong, Ran Wei, He Han, Shuang Liu, Zhenyang Zhang, Lingyao Xu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang, Zhe Zhang   +14 more
wiley   +1 more source

Exploring the Therapeutic Potential of Antidiabetic Drugs in Cardiac Arrhythmia Management: A Drug Target Mendelian Randomization Study

Journal of Arrhythmia, Volume 41, Issue 6, December 2025.
Mendelian randomization analyses suggest that genetic proxies for antidiabetic drug targets—KCNJ11/ABCC8, SLC5A2, and RXRB—reduce the risk of paroxysmal tachycardia (PT), right bundle branch block (RBBB), and atrial fibrillation (AF), respectively.
Zheng‐Qi Song, Zhi‐Bo Zhou, Bo‐Xiang Wang, Sheng‐Ke Wu, Yi‐Han Sun, Yi‐He Chen, Su‐Yin Feng, Run‐Feng Sun   +7 more
wiley   +1 more source

A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow [PDF]

, 2018
KIR6.1 (KCNJ8) is a subunit of ATP sensitive potassium channel (KATP) that plays an important role in the control of peripheral vascular tone and is highly expressed in brain contractile cells (vascular smooth muscle cells and pericytes).
Christie, IN, Aziz, Q, Niranjan, A, Anderson, N, Tinker, A, Ang, R, Wells, JA, Gourine, AV, Lythgoe, MF, Hosford, PS   +9 more
core   +2 more sources

Supplementary Material for: Induction of Genes Expressed in Endothelial Cells of the Corpus Callosum in the Chronic Cerebral Hypoperfusion Rat Model

, 2016
Background: Cerebrovascular white matter lesions (WMLs) are associated with cognitive impairment in patients with subcortical vascular dementia. We performed a comprehensive gene expression analysis to elucidate genes associated with WML development in a
Kumamoto T. (2890121), Hirano T. (2890115), Fujiki M. (2890112), Aso Y. (2890109), Takemaru M. (2890127), Nakamura K. (2890118), Kimura N. (2890124), Matsubara E. (2890130)   +7 more
core   +1 more source

The Functional Interaction of KATP and BK Channels with Aquaporin-4 in the U87 Glioblastoma Cell

Biomedicines
K+ channels do play a role in cell shape changes observed during cell proliferation and apoptosis. Research suggested that the dynamics of the aggregation of Aquaporin-4 (AQP4) into AQP4-OAP isoforms can trigger cell shape changes in malignant glioma ...
Fatima Maqoud, Laura Simone, Domenico Tricarico, Giulia Maria Camerino, Marina Antonacci, Grazia Paola Nicchia   +5 more
doaj   +1 more source

Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry [PDF]

, 2019
Cantú syndrome (CS), first described in 1982, is caused by pathogenic variants in ABCC9 and KCNJ8, which encode the regulatory and pore forming subunits of ATP-sensitive potassium (KATP) channels, respectively.
Nine V. A. M. Knoers, Gautam K. Singh, van Haelst, Mieke M., van Haaften, Gijs, Colin G. Nichols, Sarah F. Smithson, Kirk, Edwin P., Nichols, Colin G., Remedi, Maria S., Kathleen Shields, Lee, Jin-Moo, Maria S. Remedi, Mieke M. van Haelst, Smithson, Sarah F., Edwin P. Kirk, Dorothy K. Grange, Singh, Gautam K., Ingrid Scurr, Scurr, Ingrid, Roessler, Helen I., Knoers, Nine V. A. M., McClenaghan, Conor, Lee, Jin Moo, Grange, Dorothy K., Helen I. Roessler, Karen Duran, Conor McClenaghan, Duran, Karen, Shields, Kathleen, Jin‐Moo Lee, Gijs van Haaften, Knoers, Nine V.A.M.   +31 more
core   +1 more source

G024 Implication des canaux KATP dans le syndrome de repolarisation précoce [PDF]

, 2009
La repolarisation précoce est une caractéristique électro cardiographique commune (1-5 % de la population générale). Une étude récente a montré que l’incidence de la repolarisation précoce (RP) est plus élevée chez les sujets ayant présenté une ...
Chatel, S., Probst, V., H. Le Marec, R. Liersch, A. Wilde, S. Chatel, Sacher, F., Haissaguerre, M., Weerasooriya, R., Le Marec, H., M. Haissaguerre, F. Sacher, M. Horlitz, V. Probst, G. Loussouarn, Kääb, S., Liersch, R., J.-J. Schott, Horlitz, M., Schott, J.-J., Loussouarn, G., S. Kääb, Schulze-Bahr, E., Wilde, A., R. Weerasooriya, E. Schulze-Bahr   +25 more
core   +1 more source

Investigation into the molecular mechanisms underlying invasion in the lung carcinoma cell line DLKP and it's chemotherapeutic drug resistant variants [PDF]

, 2006
This research described in thesis was undertaken in an attempt to increase our knowledge of mechanisms by which lung cancer cells acquire the capacity to invade This is a critical step in cancer metastasis.
Pierce, Aisling
core   +1 more source

Investigation of the markers of sudden cardiac death and arrhytmia, and relationship of gene mutation KCNJ8-S422l in the population with early repolarization pattern on ECG

, 2012
İstanbul Bilim Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim DalıGiriş: Erken repolarizasyon (ER), EKG’de J noktasının izoelektrik hatta göre ardışık 2 derivasyonda en az 1 mm (0.1mV) yükselmesi olarak tanımlanmaktadır.
Ermiş, Emrah
core  

You Cantu : Multidisciplinary Collaboration Resulting in Successful Orthognathic Surgery.

, 2020
Cantú syndrome (CS) is a rare autosomal dominant disorder caused by a heterozygous pathogenic variant in the ABCC9 or KCNJ8 gene. The disorder is characterized by congenital generalized hypertrichosis, coarse acromegaloid facial features (broad nasal ...
Lypka, Michael, Kurian, Christopher, Pinamonti, Gina, Hughes, Susan Starling, Martin, Julie   +4 more
core   +1 more source