Results 61 to 70 of about 217 (107)

Long‐Term High‐Fat Diet Affected Bone Marrow Microenvironment During Aging at Single‐Cell Resolution

MedComm, Volume 6, Issue 8, August 2025.
High‐fat diet (HFD) promotes obesity and degenerative diseases. We established a long‐term HFD to aging (LHA) mouse model, finding it induces a bone marrow shift from osteogenesis to adipogenesis and abnormal immune cell metabolic adaptations. Signaling axes were identified through single‐cell RNA sequencing as potential bone marrow‐brain crosstalk ...
Yidan Pang, Siyuan Zhu, Peng Ding, Senyao Zhang, Yi Zhang, Fang Ye, Changqing Zhang, Junjie Gao, Jimin Yin   +8 more
wiley   +1 more source

Supplementary Material for: Induction of Genes Expressed in Endothelial Cells of the Corpus Callosum in the Chronic Cerebral Hypoperfusion Rat Model

, 2016
Background: Cerebrovascular white matter lesions (WMLs) are associated with cognitive impairment in patients with subcortical vascular dementia. We performed a comprehensive gene expression analysis to elucidate genes associated with WML development in a
Kumamoto T. (2890121), Hirano T. (2890115), Fujiki M. (2890112), Aso Y. (2890109), Takemaru M. (2890127), Nakamura K. (2890118), Kimura N. (2890124), Matsubara E. (2890130)   +7 more
core   +1 more source

Altered Immune Profiles in Non‐Failing Heart Donors With Induced Long QT Syndrome: A Potential Risk Factor for Cardiac Allograft Vasculopathy

Clinical Transplantation, Volume 39, Issue 8, August 2025.
ABSTRACT Introduction Cardiac allograft vasculopathy (CAV) develops more aggressively in recipients of hearts from brain‐dead (BD) donors with induced long QT syndrome (iLQTS), yet the underlying mechanisms remain poorly understood. In this study, we employ a multi‐omics and experimental framework to explore the role of neuro‐immune interactions in non‐
Zhi Wen, Shuai Shao, Yu Feng, Zheng Wang, Jianqiang Wu, Changxue Wu, Mingwu Tian   +6 more
wiley   +1 more source

The Functional Interaction of KATP and BK Channels with Aquaporin-4 in the U87 Glioblastoma Cell

Biomedicines
K+ channels do play a role in cell shape changes observed during cell proliferation and apoptosis. Research suggested that the dynamics of the aggregation of Aquaporin-4 (AQP4) into AQP4-OAP isoforms can trigger cell shape changes in malignant glioma ...
Fatima Maqoud, Laura Simone, Domenico Tricarico, Giulia Maria Camerino, Marina Antonacci, Grazia Paola Nicchia   +5 more
doaj   +1 more source

Supplementary Material for Russell et alWnt signaling regulates ion channel expression to promote smooth muscle and cartilage formation in developing mouse trachea

, 2023
Ion channels play critical roles in the physiology and function of the nervous system and contractile tissue; however, their role in non-contractile tissue and embryonic development has yet to be understood.
Ronak Shah (17291662), John Snowball (17291690), Megha Mohanakrishnan (17291688), Satish Madala (17291738), Natalia Bottasso-Arias (17291686), Kaulini Burra (17291659), Nicholas Russell (17291657), Harshavardhana H. Ediga (17291726), Debora Sinner (10954776)   +8 more
core   +1 more source

Investigation of the markers of sudden cardiac death and arrhytmia, and relationship of gene mutation KCNJ8-S422l in the population with early repolarization pattern on ECG

, 2012
İstanbul Bilim Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim DalıGiriş: Erken repolarizasyon (ER), EKG’de J noktasının izoelektrik hatta göre ardışık 2 derivasyonda en az 1 mm (0.1mV) yükselmesi olarak tanımlanmaktadır.
Ermiş, Emrah
core  

Notch3 directs differentiation of brain mural cells from human pluripotent stem cell-derived neural crest. [PDF]

Brain mural cells regulate development and function of the blood-brain barrier and control blood flow. Existing in vitro models of human brain mural cells have low expression of key mural cell genes, including NOTCH3. Thus, we asked whether activation of
Shusta, Eric, Snyder, Margaret, Palecek, Sean, Gastfriend, Benjamin, Holt, Hope, Daneman, Richard   +5 more
core   +1 more source

A critical role for the ATP-sensitive potassium channel subunit KIR6.1 in the control of cerebral blood flow. [PDF]

, 2018
KIR6.1 (KCNJ8) is a subunit of ATP sensitive potassium channel (KATP) that plays an important role in the control of peripheral vascular tone and is highly expressed in brain contractile cells (vascular smooth muscle cells and pericytes).
Christie, IN, Naomi Anderson, Niranjan, A, Anderson, N, Ang, R, Alexander V Gourine, Lythgoe, MF, Qadeer Aziz, Hosford, PS, Mark F Lythgoe, Jack A Wells, Arun Niranjan, Richard Ang, Aziz, Q, Patrick S Hosford, Tinker, A, Andrew Tinker, Wells, JA, Gourine, AV, Isabel N Christie   +19 more
core   +1 more source

Investigating Angiogenesis-Related Biomarkers in Osteoarthritis Patients Through Transcriptomic Profiling

Journal of Inflammation Research
Yang Zheng,1 Miaojia Fang,2 Shriya Sanan,1 Xi-Hui Meng,1 Jie-Feng Huang,1 Yu Qian1 1Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, People’s Republic of China; 2Institute of Forensic Science, Yuhang Public Security Department ...
Zheng Y, Fang M, Sanan S, Meng XH, Huang JF, Qian Y   +5 more
doaj  

Investigation into the molecular mechanisms underlying invasion in the lung carcinoma cell line DLKP and it's chemotherapeutic drug resistant variants [PDF]

, 2006
This research described in thesis was undertaken in an attempt to increase our knowledge of mechanisms by which lung cancer cells acquire the capacity to invade This is a critical step in cancer metastasis.
Pierce, Aisling
core