Results 31 to 40 of about 7,235 (159)
KDM6A addiction of cervical carcinoma cell lines is triggered by E7 and mediated by p21CIP1 suppression of replication stress. [PDF]
PLoS Pathogens, 2017 Expression of E7 proteins encoded by carcinogenic, high-risk human papillomaviruses (HPVs) triggers increased expression of the histone H3 lysine 27 demethylase KDM6A.
David R Soto +3 more
doaj +1 more source
Translational Oncology, 2023 Background and aims: Wnt signaling is essential for the maintenance of cancer stem cells (CSCs), but mutations in the β-catenin and APC genes are less common in non-small cell lung carcinoma (NSCLC).
Zhiwei Chen +3 more
doaj +1 more source
The Role of Kdm6a in Normal Hematopoiesis
Blood, 2016 Abstract The role of the X-linked H3K27 demethylase KDM6A in normal hematopoiesis remains unclear. We generated Kdm6a conditional knockout mice (with LoxP sites flanking the 3rd exon) and crossed these mice with Vav1-Cre mice to inactivate Kdm6a in hematopoietic stem/progenitor cells.
Ling Tian, Lukas D. Wartman
openaire +2 more sources
BMJ Oncology, 2023 Objective KDM6A, a representative tumour suppressor gene with sex bias, is frequently altered in urothelial carcinoma (UC). The specific impacts of KDM6A mutations on gender-based clinical outcomes in UC remain poorly understood.Methods and analysis We ...
Weijuan Zhang +14 more
doaj +1 more source
Metformin directly targets the H3K27me3 demethylase KDM6A/UTX [PDF]
Aging Cell, 2018 SummaryMetformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of aging per se, has been clinically exploited for decades in the absence of a complete understanding of its therapeutic targets or chemical determinants.
Elisabet Cuyàs +14 more
openaire +5 more sources
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade [PDF]
Nature Communications, 2021 Abstract Despite the genetic inactivation of SMARCA4 , a core component of the SWI/SNF-complex commonly found in cancer, there are no therapies that effectively target SMARCA4-deficient tumours. Here, we show that, unlike the cells with activated MYC
Octavio A. Romero +19 more
openaire +9 more sources
The histone demethylase UTX/KDM6A in cancer: Progress and puzzles [PDF]
International Journal of Cancer, 2019 The lysine‐specific demethylase 6A/UTX (gene name KDM6A) acts as a component of the COMPASS complex to control gene activation. UTX demethylates H3K27me2/3 at genes and enhancers. Deleterious mutations in KDM6A are found in many cancer types, prominently urothelial carcinoma and certain T‐cell leukemias.
Wolfgang A. Schulz +3 more
openaire +2 more sources
KDM6A facilitates Xist upregulation at the onset of X inactivation
, 2023 Abstract X chromosome inactivation (XCI) is a female-specific process in which one X chromosome is silenced to balance X-linked gene expression between the sexes. XCI is initiated in early development by upregulation of the lncRNA Xist on the future inactive X (Xi).
Josephine Lin +10 more
openaire +2 more sources
KDM6A mutations promote acute cytoplasmic DNA release, DNA damage response and mitosis defects
BMC Molecular and Cell Biology, 2021 Background KDM6A, encoding a histone demethylase, is one of the top ten mutated epigenetic cancer genes. The effect of mutations on its structure and function are however poorly characterized.
J. Koch +5 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: Although trimethylation of histone H3 lysine 27 (H3K27me3) by polycomb repressive complex 2 is required for intestinal function, the role of the antagonistic process—H3K27me3 demethylation—in the intestine remains unknown.
Hannah M. Kolev +6 more
doaj +1 more source