Results 21 to 30 of about 7,235 (159)

KDM6A facilitates Xist upregulation at the onset of X inactivation

Biology of Sex Differences
Background X chromosome inactivation (XCI) is a female-specific process in which one X chromosome is silenced to balance X-linked gene expression between the sexes.
Josephine Lin, Jinli Zhang, Li Ma, He Fang, Rui Ma, Camille Groneck, Galina N. Filippova, Xinxian Deng, Chizuru Kinoshita, Jessica E. Young, Wenxiu Ma, Christine M. Disteche, Joel B. Berletch   +12 more
doaj   +5 more sources

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML‐Like Disease Through JAK/STAT3 Activation by Repressing SOCS3 [PDF]

Advanced Science
Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy with a poor prognosis and limited targeted therapies. Lysine demethylase 6A (KDM6A), a H3K27 demethylase and key component of the COMPASS complex, is frequently mutated in hematologic ...
Huiqiao Chen, Shufen Wang, Ruoyu Dong, Pinhui Yu, Tianyu Li, Liangning Hu, Mowang Wang, Zijun Qian, Hongyu Zhou, Xiaoyan Yue, Limengmeng Wang, Haowen Xiao   +11 more
doaj   +2 more sources

Folate affects neural tube development through KDM6A [PDF]

Jichu yixue yu linchuang, 2020
Objective To investigate the effects of lysine-specific demethylase 6A (KDM6A) on neural tube defects (NTDs) in low folate environment. Methods Mouse embryonic stem cells (SV129), NTD mouse models and NTD human specimens were used.
GAO Jun, LI Jian-ting, XIE Qiu, ZHANG Yong-feng, QIAO Li-na, LIU Chang-yun, WANG Jian-hua
doaj   +1 more source

KDM6A Regulates Cell Plasticity and Pancreatic Cancer Progression by Noncanonical Activin PathwaySummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Inactivating mutations of KDM6A, a histone demethylase, were frequently found in pancreatic ductal adenocarcinoma (PDAC). We investigated the role of KDM6A (lysine demethylase 6A) in PDAC development.
Zhujun Yi, Shanqiao Wei, Lin Jin, Sivakumar Jeyarajan, Jing Yang, Yumei Gu, Hong Sun Kim, Shula Schechter, Shuang Lu, Michelle T. Paulsen, Karan Bedi, Ishwarya Venkata Narayanan, Mats Ljungman, Howard C. Crawford, Marina Pasca di Magliano, Kai Ge, Yali Dou, Jiaqi Shi   +17 more
doaj   +1 more source

Epigenetic modifier Kdm6a/Utx controls the specification of hypothalamic neuronal subtypes in a sex-dependent manner

Frontiers in Cell and Developmental Biology, 2022
Kdm6a is an X-chromosome-linked H3K27me2/3 demethylase that promotes chromatin accessibility and gene transcription and is critical for tissue/cell-specific differentiation.
Lucas E. Cabrera Zapata, María Julia Cambiasso, María Julia Cambiasso, Maria Angeles Arevalo, Maria Angeles Arevalo   +4 more
doaj   +1 more source

Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype.

PLoS ONE, 2021
Kdm6a/Utx, a gene on the X chromosome, encodes a histone H3K27me3 demethylase that has an orthologue on the Y chromosome (Uty) (Zheng et al. 2018). We previously identified inactivating mutations of Kdm6a in approximately 50% of mouse acute promyelocytic
Ling Tian, Monique Chavez, Gue Su Chang, Nichole M Helton, Casey D S Katerndahl, Christopher A Miller, Lukas D Wartman   +6 more
doaj   +2 more sources

Allele-Specific Gene Regulation by Kdm6a [PDF]

SSRN Electronic Journal, 2019
SUMMARY KDM6A demethylates the repressive histone mark H3K27me3 and thus plays an important role in developmental gene regulation. KDM6A expression is female-biased due to escape from X inactivation, suggesting that this protein may play a role in sex differences.
Wenxiu Ma, He Fang, Nicolas Pease, Galina N. Filippova, Christine M. Disteche, Joel B. Berletch   +5 more
openaire   +1 more source

Epigenetic condensates regulate chromatin activity and tumorigenesis

Molecular & Cellular Oncology, 2021
Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear.
Bi Shi, Wei Li, Hao Jiang
doaj   +1 more source

Contingencies of UTX/KDM6A Action in Urothelial Carcinoma [PDF]

Cancers, 2019
The histone demethylase Ubiquitously Transcribed Tetratricopeptide Repeat Protein X-Linked (UTX/KDM6A) demethylates H3K27me2/3 at genes and enhancers and is often inactivated by mutations in urothelial carcinoma (UC). The consequences of its inactivation are however poorly understood. We have investigated the consequences of moderate UTX overexpression
Alexander Lang, Merve Yilmaz, Christiane Hader, Sammy Murday, Xenia Kunz, Nicholas Wagner, Constanze Wiek, Patrick Petzsch, Karl Köhrer, Julian Koch, Michéle J. Hoffmann, Annemarie Greife, Wolfgang A. Schulz   +12 more
openaire   +2 more sources

Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity‐Related Properties

Advanced Science, 2021
The trimethylation on histone H3 lysine 27 (H3k27me3), a transcriptionally repressive epigenetic mark of permissive chromatin, can be removed by the histone lysine demethylase 6a (Kdm6a).
Yan Wei, Jun Chen, Xing Xu, Fan Li, Kun Wu, Yingying Jiang, Yuqing Rao, Chen Zhao, Wantao Chen, Xu Wang   +9 more
doaj   +1 more source