Significance of KDM6A mutation in bladder cancer immune escape [PDF]
BMC Cancer, 2021 Background Bladder cancer (BC) is the fourth most prevalent neoplasm in men and is associated with high tumour recurrence rates, leading to major treatment challenges.
Xingxing Chen +5 more
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Differential Occupancy and Regulatory Interactions of KDM6A in Bladder Cell Lines
Cells, 2023 Epigenetic deregulation is a critical theme which needs further investigation in bladder cancer research. One of the most highly mutated genes in bladder cancer is KDM6A, which functions as an H3K27 demethylase and is one of the MLL3/4 complexes.
Gülden Özden-Yılmaz +8 more
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Sex-biased and parental allele-specific gene regulation by KDM6A [PDF]
Biology of Sex Differences, 2022 Highlights The majority of KDM6A targets are regulated from one allele or the other with allelic downregulation showing a maternal allele bias. Kdm6a knockout affects genes that have been implicated in phenotypes of Kabuki syndrome caused by KDM6A ...
Wenxiu Ma +5 more
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HIF-independent oxygen sensing via KDM6A regulates ferroptosis [PDF]
Molecular CellFerroptosis, a metabolic cell death process driven by iron-dependent phospholipid peroxidation, is implicated in various pathologies, including cancer. While metabolic factors such as glucose, lipids, and multiple amino acids have all been demonstrated to modulate ferroptosis, the role of oxygen, another fundamental metabolic component, in ferroptosis ...
Yueming Li +2 more
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KDM6A-ARHGDIB axis blocks metastasis of bladder cancer by inhibiting Rac1 [PDF]
Molecular Cancer, 2021 Background KDM6A, a histone demethylase, is frequently mutated in bladder cancer (BCa). However, the role and detailed molecular mechanism of KDM6A involved in bladder cancer progression remains unknown.
Lei Liu +10 more
doaj +3 more sources
Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A. [PDF]
PLoS Genetics, 2013 The Rhox cluster on the mouse X chromosome contains reproduction-related homeobox genes expressed in a sexually dimorphic manner. We report that two members of the Rhox cluster, Rhox6 and 9, are regulated by de-methylation of histone H3 at lysine 27 by ...
Joel B Berletch +3 more
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Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration
Advanced ScienceEpigenetic regulation of neuronal transcriptomic landscape is emerging to be a key coordinator of mammalian neural regeneration. The roles of two histone 3 lysine 27 (H3K27) demethylases, Kdm6a/b, in controlling neuroprotection and axon regeneration are ...
Shu‐Guang Yang +13 more
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Inactivation of KDM6A promotes the progression of colorectal cancer by enhancing the glycolysis
European Journal of Medical ResearchKDM6A (lysine demethylase 6A) has been reported to undergo inactivating mutations in colorectal cancer, but its function in the progression of colorectal cancer has not been evaluated using animal models of colorectal cancer. In this study, we found that
Dexiang Zhang +7 more
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Genome-wide CRISPR/Cas9 screening identifies PTGR2 as a potential therapeutic target for sunitinib resistance in clear cell renal cell carcinoma [PDF]
Scientific ReportsAcquired and intrinsic resistance to sunitinib is a major obstacle to improving the therapeutic efficacy of treatment for clear cell renal cell carcinoma (ccRCC).
Wei Chang +9 more
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Insertion/Deletion Within the KDM6A Gene Is Significantly Associated With Litter Size in Goat
Frontiers in Genetics, 2018 A previous whole-genome association analysis identified lysine demethylase 6A (KDM6A), which encodes a type of histone demethylase, as a candidate gene associated to goat fecundity.
Lei Qu, Chuanying Pan
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