Results 1 to 10 of about 3,950 (160)

Activation of epigenetic regulator KDM6B by Salmonella Typhimurium enables chronic infections [PDF]

Gut Microbes, 2021
Non-typhoidal Salmonella (NTS) infections result in self limiting gastroenteritis except in rare cases wherein manifestations of chronic infections can occur.
C V Srikanth, Gayatree Mohapatra, Savita Singh   +2 more
exaly   +5 more sources

Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/β‐catenin signaling

FEBS Open Bio, 2021
Tumor metastasis remains a major challenge for patients with breast cancer. Aberrant epigenetic factor lysine‐specific demethylase 6B (KDM6B) has been associated with tumor progression.

exaly   +2 more sources

KDM6B safeguards mineralized tissue homeostasis from mechanical stress through epigenetic control of PIEZO1-mediated mechanotransduction in the mouse incisor [PDF]

Bone Research
Mechanical forces shape the growth and regeneration of mineralized tissues such as bones and teeth, yet how these tissues adapt to sustained mechanical stress remains poorly understood. Here, using mouse incisor models with varying degrees of loading, we
Lin Meng, Mingyi Zhang, Jifan Feng, Tingwei Guo, Hana Hekmat, Heliya Ziaei, Peng Chen, Aaron Harouni, Thach-Vu Ho, Yang Chai   +9 more
doaj   +2 more sources

KDM6B promotes ferroptosis in rheumatoid arthritis fibroblast-like synoviocytes via the miR-128-3p/SLC7A11 axis through H3K27me3 modification [PDF]

Journal of Orthopaedic Surgery and Research
Background Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, primarily driven by fibroblast-like synoviocytes (FLSs) that trigger synovial inflammation and joint destruction.
Bin Wang, Song Gao, Zongwei Liu, Yan Cong, Chuansheng Wu   +4 more
doaj   +2 more sources

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer [PDF]

Advanced Science
Colorectal cancer (CRC) progression is regulated by an immunosuppressive tumor microenvironment, but the epigenetic mechanisms governing this milieu remain unclear. This study identifies the histone demethylase KDM6B as a key regulator of myeloid‐derived
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
doaj   +2 more sources

T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis [PDF]

The Journal of Clinical Investigation
Tregs expressing forkhead box P3 (FOXP3) play crucial roles in maintaining immune tolerance and tissue integrity. EZH2, a histone H3 lysine 27 (H3K27) methyltransferase, is known as a key regulator of Treg identity and suppressive function upon ...
Minghong He, Beisi Xu, Pria G. Bose, Morgan J. McCullough, Rani S. Sellers, Xinying Zong, Wenjie Qi, Brianna L. Banten, Miriya K. Tune, Matthew P. Zimmerman, Genevieve Mullins, Brian C. Miller, J. Justin Milner, Jason K. Whitmire, Ageliki Tsagaratou, Karl B. Shpargel, Claire M. Doerschuk, Yong-Dong Wang, Jacob A. Steele, Shondra M. Pruett-Miller, Yongqiang Feng, Jason R. Mock   +21 more
doaj   +2 more sources

KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation [PDF]

International Journal of Oral Science
Periodontitis is a common chronic inflammatory disease that ultimately results in irreversible tooth loss. Cementum, a bone-like tissue surrounding tooth roots, deteriorates as periodontitis advances, ultimately causing tooth loss.
Zhengkun Yang, Huiyi Wang, Junhong Xiao, Qiudong Yang, Jiahui Sun, Heyu Liu, Zhendong Huang, Li Ma, Xin Huang, Chuan Wang, Xiaoxuan Wang, Zhengguo Cao   +11 more
doaj   +2 more sources

METTL3/RBM15 augments the stability of Kdm6b mRNA and promotes STAT1-mediated macrophage activation and atherosclerosis [PDF]

Experimental and Molecular Medicine
Atherosclerosis is the underlying cause of cardiovascular disease. Recent studies have shown that N 6-methyladenosine (m6A) modification in macrophages is associated with atherosclerosis progression.
Ning Huangfu, Fang Li, Chenqiu Wang, Shouyi Jin, Xiaoya Zheng, Yingsong Wang, Tianxiang Fang, Jiaxi Shen, Yanan Yu, Liguo Jian, Datun Qi, Wenting Zhao, Dongdong Jian   +12 more
doaj   +2 more sources

KDM6B induces demethylation of H3K27me3 in MFN1 to modulate aberrant mitophagy in sepsis-induced acute lung injury [PDF]

Scientific Reports
Acute lung injury (ALI) commonly occurs as a complication of sepsis, significantly increasing mortality rates in septic patients. Macrophages play a critical role in sepsis pathogenesis.
Haoran Deng, Shiping Zhu, Xue Song, Yufei Guo, Xuchun Ding   +4 more
doaj   +2 more sources

KDM6B inhibition enhances chemotherapeutic response in small cell lung cancer via epigenetic regulation of apoptosis and ferroptosis [PDF]

Cell & Bioscience
Background Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid progression and the frequent emergence of resistance to standard chemotherapeutic agents such as cisplatin (DDP) and etoposide (VP16), resulting in poor ...
Zhongliang Wang, Ziyuan Liu, Yufan Yang, Wenyang Wang, Qian Chen, Shumei Liang, Linlang Guo, Man Li   +7 more
doaj   +2 more sources