Results 21 to 30 of about 3,950 (160)

Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b [PDF]

Science, 2020
How egg temperature sets sex In many reptiles, sex is determined by nest temperature during egg incubation. Temperature regulates the expression of an epigenetic modifier gene called Kdm6b , which is responsible for testis development.
Ceri Weber, Yingjie Zhou, Jong Gwan Lee, Loren L. Looger, Guoying Qian, Chutian Ge, Blanche Capel   +6 more
openaire   +7 more sources

KDM6B promotes ESCC cell proliferation and metastasis by facilitating C/EBPβ transcription

BMC Cancer, 2021
Background As an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression, KDM6B has been implicated in the development and malignant progression in various types of cancers. However, its potential roles in esophageal squamous cell
Mei Qin, Fei Han, Jian Wu, Feng-xia Gao, Yuan Li, De-xin Yan, Xue-mei He, Yang Long, Xiao-ping Tang, De-lian Ren, Yan Gao, Tian-yang Dai   +11 more
doaj   +1 more source

GSK-J4 Inhibition of KDM6B Histone Demethylase Blocks Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells by Modulating NF-κB Signaling

Cells, 2023
Multiple signaling pathways facilitate the survival and drug resistance of malignant B-cells by regulating their migration and adhesion to microenvironmental niches.
Laia Sadeghi, Anthony P. H. Wright
doaj   +1 more source

Myeloid Kdm6b deficiency results in advanced atherosclerosis [PDF]

Atherosclerosis, 2018
Atherosclerosis is a lipid-driven chronic inflammatory disorder of the arteries, and monocytes and macrophages play a central role in this process. Within the atherosclerotic lesion, macrophages can scavenge modified lipids and become the so-called foam cells.
Neele, Annette E., Gijbels, Marion J.J., van der Velden, Saskia, Hoeksema, Marten A., Boshuizen, Marieke C.S., Prange, Koen H.M., Chen, Hung-Jen, Van den Bossche, Jan, van Roomen, Cindy P.P.A., Shami, Annelie, Levels, Johannes H.M., Kroon, Jeffrey, Lucas, Tina, Dimmeler, Stefanie, Lutgens, Esther, de Winther, Menno P.J.   +15 more
openaire   +2 more sources

Histone Demethylase KDM6B Promotes Epithelial-Mesenchymal Transition [PDF]

Journal of Biological Chemistry, 2012
Epithelial-mesenchymal transition (EMT) is a critical event that occurs in embryonic development, tissue repair control, organ fibrosis, and carcinoma invasion and metastasis. Although significant progress has been made in understanding the molecular regulation of EMT, little is known about how chromatin is modified in EMT.
Sivakumar, Ramadoss, Xiaohong, Chen, Cun-Yu, Wang   +2 more
openaire   +2 more sources

KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer

Cell Death and Disease, 2021
Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, plays oncogenic or antitumoral roles in malignant tumors depending on the type of tumor cell.
Zhi Cao, Xiaolei Shi, Feng Tian, Yu Fang, Jason Boyang Wu, Stefan Mrdenovic, Xinwen Nian, Jin Ji, Huan Xu, Chen Kong, Yalong Xu, Xi Chen, Yuhua Huang, Xuedong Wei, Yongwei Yu, Bo Yang, Leland W. K. Chung, Fubo Wang   +17 more
doaj   +1 more source

KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis

eLife, 2022
Epigenetic regulation plays extensive roles in diseases and development. Disruption of epigenetic regulation not only increases the risk of cancer, but can also cause various developmental defects.
Tingwei Guo, Xia Han, Jinzhi He, Jifan Feng, Junjun Jing, Eva Janečková, Jie Lei, Thach-Vu Ho, Jian Xu, Yang Chai   +9 more
doaj   +1 more source

The ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells

Bone Research, 2022
Osteoporosis is a highly prevalent public health burden associated with an increased risk of bone fracture, particularly in aging women. Estrogen, an important medicinal component for the preventative and therapeutic treatment of postmenopausal ...
Zhenqing Liu, Hye-Lim Lee, Jin Sook Suh, Peng Deng, Chang-Ryul Lee, Olga Bezouglaia, Mojan Mirnia, Vivian Chen, Michael Zhou, Zhong-Kai Cui, Reuben H. Kim, Min Lee, Tara Aghaloo, Christine Hong, Cun-Yu Wang   +14 more
doaj   +1 more source

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration. [PDF]

Adv Sci (Weinh)
Abstract Epigenetic regulation of neuronal transcriptomic landscape is emerging to be a key coordinator of mammalian neural regeneration. The roles of two histone 3 lysine 27 (H3K27) demethylases, Kdm6a/b, in controlling neuroprotection and axon regeneration are investigated here.
Yang SG, Li CP, Wang XW, Huang T, Qian C, Li Q, Zhao LR, Zhou SY, Ding CY, Nie R, Saijilafu, Hong YC, Liu CM, Zhou FQ.   +13 more
europepmc   +4 more sources

KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

Nature Communications, 2021
The histone demethylase KDM6B is reported to be essential for neuroblastoma cell survival. Here the authors show that KDM6B regulates CDK4/6-pRB-E2F pathway through H3K27me3-dependent enhancer-promoter interactions in neuroblastoma.
Alexandra D’Oto, Jie Fang, Hongjian Jin, Beisi Xu, Shivendra Singh, Anoushka Mullasseril, Victoria Jones, Ahmed Abu-Zaid, Xinyu von Buttlar, Bailey Cooke, Dongli Hu, Jason Shohet, Andrew J. Murphy, Andrew M. Davidoff, Jun Yang   +14 more
doaj   +1 more source