Results 41 to 50 of about 3,950 (160)

Human histone demethylase KDM6B can catalyse sequential oxidations

Chemical Communications, 2018
Biochemical studies on the histone lysyl demethylase KDM6B reveal it is capable of catalysing reactions on multiple lysine analogues, forming de-alkylated, hydroxylated, and oxidised products.
Richard J. Hopkinson, Gareth W. Langley, Roman Belle, Louise J. Walport, Kate Dunne, Martin Münzel, Eidarus Salah, Akane Kawamura, Timothy D. W. Claridge, Christopher J. Schofield   +9 more
openaire   +5 more sources

The Histone H3K27me3 Demethylases KDM6A/B Resist Anoikis and Transcriptionally Regulate Stemness-Related Genes

Frontiers in Cell and Developmental Biology, 2022
Epithelial cancer cells that lose attachment from the extracellular matrix (ECM) to seed in a distant organ often undergo anoikis’s specialized form of apoptosis. Recently, KDM3A (H3K9 demethylase) has been identified as a critical effector of anoikis in
Mohammed Razeeth Shait Mohammed, Mohammed Razeeth Shait Mohammed, Mazin Zamzami, Hani Choudhry, Hani Choudhry, Firoz Ahmed, Firoz Ahmed, Bushra Ateeq, Mohammad Imran Khan, Mohammad Imran Khan   +9 more
doaj   +1 more source

KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice [PDF]

Blood Advances, 2018
Abstract KDM6B is an epigenetic regulator that mediates transcriptional activation during differentiation, including in bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs). Overexpression of KDM6B has been reported in BM HSPCs of patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML ...
Yue Wei, Hong Zheng, Naran Bao, Shan Jiang, Carlos E. Bueso-Ramos, Joseph Khoury, Caleb Class, Yue Lu, Kevin Lin, Hui Yang, Irene Ganan-Gomez, Daniel T. Starczynowski, Kim-Anh Do, Simona Colla, Guillermo Garcia-Manero   +14 more
openaire   +3 more sources

KDM6B is a conserved activator at the top of the male sex determination pathway.

Development
ABSTRACT In mammals, commitment to the testis fate is controlled by the gene Sry on the Y chromosome; however, how Sry is regulated is not well understood. In the red-eared slider turtle, Dmrt1 acts as the primary activator of the testis pathway.
Dupont SM, Garcia-Moreno A, O'Neil EV, Capel BC.   +3 more
europepmc   +3 more sources

Integrative bioinformatics and validation studies reveal KDM6B and its associated molecules as crucial modulators in Idiopathic Pulmonary Fibrosis

Frontiers in Immunology, 2023
BackgroundIdiopathic Pulmonary Fibrosis (IPF) can be described as a debilitating lung disease that is characterized by the complex interactions between various immune cell types and signaling pathways.
Anning Chen, Zhun Sun, Donglin Sun, Meiying Huang, Hongwei Fang, Jinyuan Zhang, Guojun Qian   +6 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma

Theranostics, 2021
Rationale: Osteosarcoma (OS), the most common type of bone tumor, which seriously affects the patients' limb function and life quality. OS has a strong tendency of lung metastasis, and the five-year survival rate of patients with metastatic osteosarcoma is less than 20%. Thus, new treatment targets and strategies are urgently needed.
Jiang, Yuhang, Li, Fengfeng, Gao, Bowen, Ma, Mengjun, Chen, Meng, Wu, Yanfeng, Zhang, Weidong, Sun, Yangbai, Liu, Sanhong, Shen, Huiyong   +9 more
openaire   +2 more sources

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae [PDF]

Nature Microbiology, 2019
Abstract Streptococcus pneumoniae is a natural colonizer of the human upper respiratory tract and an opportunistic pathogen. After colonization, bacteria either remain in the human upper respiratory tract, or may progress to cause pneumococcal disease. Although epithelial cells are among the first to
Michael G. Connor, Tiphaine M. N. Camarasa, Emma Patey, Orhan Rasid, Laura Barrio, Caroline M. Weight, Daniel P. Miller, Robert S. Heyderman, Richard J. Lamont, Jost Enninga, Melanie A. Hamon   +10 more
openaire   +4 more sources

The gut microbiome organ

iMeta, EarlyView.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source