Results 61 to 70 of about 3,950 (160)

MicroRNA‐99a is a novel regulator of KDM6B‐mediated osteogenic differentiation of BMSCs

Journal of Cellular and Molecular Medicine, 2018
AbstractSkeletal tissue originates from mesenchymal stem cells (MSCs) with differentiation potential into the osteoblast lineage regulated by essential transcriptional and post‐transcriptional mechanisms. Recently, miRNAs and histone modifications have been identified as novel key regulators of osteogenic differentiation of MSCs.
Yin Tang, Lan Zhang, Tianchi Tu, Yijia Li, Dana Murray, Qisheng Tu, Jake Jinkun Chen   +6 more
openaire   +2 more sources

Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis

iScience, 2023
Summary: Cell reprogramming to a myofibroblast responsible for the pathological accumulation of extracellular matrix is fundamental to the onset of fibrosis. Here, we explored how condensed chromatin structure marked by H3K72me3 becomes modified to allow
Morgan D. Basta, Svetlana Petruk, Ross Summer, Joel Rosenbloom, Peter J. Wermuth, Edward Macarak, Alex V. Levin, Alexander Mazo, Janice L. Walker   +8 more
doaj   +1 more source

Tricarboxylic Acid (TCA) Cycle Enzyme Alpha‐Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization

Journal of Cellular Biochemistry, Volume 127, Issue 7, July 2026.
ABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Meijing Li, Ryan J. Mailloux
wiley   +1 more source

Depletion of Demethylase KDM6 Enhances Early Neuroectoderm Commitment of Human PSCs

Frontiers in Cell and Developmental Biology, 2021
Epigenetic modifications play a crucial role in neurogenesis, learning, and memory, but the study of their role in early neuroectoderm commitment from pluripotent inner cell mass is relatively lacking.
Yajing Meng, Tianzhe Zhang, Ran Zheng, Song Ding, Jie Yang, Ran Liu, Yingan Jiang, Wei Jiang, Wei Jiang, Wei Jiang   +9 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Genetic Bone Diseases: A Scoping Review of Pathology, Symptoms, Diagnosis, Treatment, and New Horizons

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review highlights six genetic diseases of the bone, aiming to provide clinicians and researchers with updated information on their diagnosis and treatment. It also includes an assessment of common clinical and radiographic findings, along with pathophysiology related to diseases.
Colin Jones, Ambalangodage C. Jayasuriya
wiley   +1 more source

MyGene2 automated match report: KDM6B

, 2019
MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If
openaire   +1 more source

Alcohol-induced suppression of KDM6B dysregulates the mineralization potential in dental pulp stem cells

Stem Cell Research, 2016
Epigenetic changes, such as alteration of DNA methylation patterns, have been proposed as a molecular mechanism underlying the effect of alcohol on the maintenance of adult stem cells.
Michael Hoang, Jeffrey J. Kim, Yiyoung Kim, Elizabeth Tong, Benjamin Trammell, Yao Liu, Songtao Shi, Chang-Ryul Lee, Christine Hong, Cun-Yu Wang, Yong Kim   +10 more
doaj   +1 more source

Roles of histone lysine methylation in neurodevelopment and related disorders

Ibrain, Volume 12, Issue 2, Page 201-221, Summer 2026.
This graphical abstract centers on the theme of dynamic balance and systematically outlines the role of histone lysine methylation in neurodevelopment and related disorders. The figure first presents two key classes of regulators that control this balance—“writers” and “erasers”—and then indicates how interactions among different epigenetic ...
Yun Chen, Yi Zhang, Hong Zhang, Xiaoli Liang   +3 more
wiley   +1 more source

Identification of 2‐Substituted‐3‐Hydroxy‐2,3‐Dihydroquinazolin‐4(1H) Ones as Cell‐Active Inhibitors of KDM4A Lysine Demethylase

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A novel 3‐hydroxy‐2,3‐dihydroquinazolinone scaffold is identified as a cell‐active KDM4A inhibitor through an orthogonal screening cascade minimizing assay interference. Integrated biochemical, biophysical, and proteomic validation reveals compound 6i as a bona fide binder that increases H3K9 methylation in cells, highlighting both a promising ...
Alessandra Feoli, Amodio Luca Balzano, Ida Pacilio, Alessandra Cipriano, Roman Belle, Giacomo Pepe, Manuela Giovanna Basilicata, Pietro Campiglia, Fabrizio Micheli, Akane Kawamura, Ciro Milite, Sabrina Castellano, Axel Imhof, Gianluca Sbardella   +13 more
wiley   +1 more source