Results 71 to 80 of about 3,950 (160)

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3

PLOS ONE, 2016
SUMMARY The growth factor and cytokine regulated transcription factor STAT3 is required for the self-renewal of several stem cell types including tumor stem cells from glioblastoma. Here we show that STAT3 inhibition leads to the upregulation of the histone H3K27me2/3 demethylase Jmjd3 (KDM6B), which can reverse polycomb complex ...
Sherry-Lynes, Maureen M., Sengupta, Sejuti, Kulkarni, Shreya, Cochran, Brent H.   +3 more
openaire   +4 more sources

Kdm6b regulates context-dependent hematopoietic stem cell self-renewal and leukemogenesis [PDF]

Leukemia, 2019
The histone demethylase KDM6B (JMJD3) is upregulated in blood disorders, suggesting that it may have important pathogenic functions. Here we examined the function of Kdm6b in hematopoietic stem cells (HSC) to evaluate its potential as a therapeutic target.
Cates Mallaney, Elizabeth L. Ostrander, Hamza Celik, Ashley C. Kramer, Andrew Martens, Alok Kothari, Won Kyun Koh, Emily Haussler, Naoki Iwamori, Paul Gontarz, Bo Zhang, Grant A. Challen   +11 more
openaire   +2 more sources

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

Cytoreductive nephrectomy in the era of immune‐checkpoint inhibitors: back to the future?

BJU International, Volume 137, Issue 5, Page 763-769, May 2026.
Objective To investigate the role of cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) treated with immune‐checkpoint inhibitors (ICIs). Methods A narrative review was carried out using PubMed and searching for English articles published from January 2015 to May 2025.
Rocco Simone Flammia, Riccardo Campi, Eugenio Bologna, Riccardo Bertolo, Costantino Leonardo, Fabio Calabrò, Daniele Amparore, Giuseppe Simone, on behalf of the Young Academic Urologists (YAU) Renal Cancer Working Group   +8 more
wiley   +1 more source

The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases

Exploration, Volume 6, Issue 2, April 2026.
This review explores the critical role of mitochondria in heart development and cardiovascular disease. It highlights how mitochondrial maturation during embryonic‐to‐postnatal transition, regulated by oxygen and metabolic changes, shapes cardiac structure and function.
Minghao Li, Ruiyi Zhang, Xinyuan Li, Hefeng Huang   +3 more
wiley   +1 more source

Active H3K27me3 demethylation by KDM6B is required for normal development of bovine preimplantation embryos

Epigenetics, 2017
The substantial epigenetic remodeling that occurs during early stages of mammalian embryonic development likely contributes to reprogramming the parental genomes from a differentiated to a totipotent state and activation of the embryonic genome ...
Nhi Chung, Yanina S. Bogliotti, Wei Ding, Marcela Vilarino, Kazuki Takahashi, James L. Chitwood, Richard M. Schultz, Pablo J. Ross   +7 more
doaj   +1 more source

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source

Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B

Cell Communication and Signaling
Testicular germ cell tumors (TGCTs) can be treated with cisplatin-based therapy. However, a clinically significant number of cisplatin-resistant patients die from progressive disease as no effective alternatives exist.
Doha Shokry, Mehwish W. Khan, Christine Powell, Samantha Johnson, Brayden C. Rennels, Raya I. Boyd, Zhengyang Sun, Zeeshan Fazal, Sarah J. Freemantle, Maryanna H. Parker, Miranda D. Vieson, Jonathan P. Samuelson, Michael J. Spinella, Ratnakar Singh   +13 more
doaj   +1 more source

Kdm6b-mediated epigenetic coordination of temporal precision during motor neuron differentiation

EMBO Reports
Histone modifiers are crucial for instructing multiple-stage cellular differentiation, yet the mechanisms underlying their temporal precision remain enigmatic.
Haihan Ren, Qicheng Liu, Bingqian Li, Xuetong Yu, Dan Liang, Shuangling Li, Bing Pan, Qian Gao, Wenhong Deng, Jun-Ma Yu, Wenxian Wang   +10 more
doaj   +1 more source