Results 91 to 100 of about 3,950 (160)

KDM6B wt Allele [PDF]

, 2020
openaire   +1 more source

Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven mTOR pathway in hematopoietic progenitor cells

The Journal of Clinical Investigation
Ecotropic viral integration site 1 (EVI1/MECOM) is frequently upregulated in myeloid malignancies. Here, we present an Evi1-transgenic mouse model with inducible expression in hematopoietic stem/progenitor cells (HSPCs). Upon induction of Evi1 expression,
Qiong Wu, Chunjie Yu, Fang Yu, Yiran Guo, Yue Sheng, Liping Li, Yafang Li, Yutao Zhang, Chao Hu, Jue Wang, Tong-chuan He, Yong Huang, Hongyu Ni, Zhiguang Huo, Wenshu Wu, Gang Greg Wang, Jianxin Lyu, Zhijian Qian   +17 more
doaj   +1 more source

Kdm6b functions in lineage specification of the TE in hES cells.

We measured total transcription in the inner cell mass (ICM) and the trophectoderm (TE) of the human embryo to understand the mechanisms underlying TE commitment. We describe here discovery of Kdm6b as a lineage commitment factor in embryonic stem cells of the human embryo. 
openaire   +2 more sources

Roles of KDM6B and EZH2 Iin epithelial to mesenchymal transition

, 2020
EZH2 et KDM6B catalysent respectivement la méthylation et la déméthylation de la marque épigénétique H3K27me3 (triméthylation de la lysine 27 de l’histone 3). Elles sont dérégulées dans de nombreux types de cancers. Nos travaux montrent que l’expression de KDM6B et EZH2 sont corrélées dans les cancers du poumon non à petites cellules et sont corrélées ...
openaire   +1 more source

Fragile histidine triad (FHIT) suppresses gastric cancer via translational regulation of the epigenetic modifier KDM6B. [PDF]

J Biol Chem
Hu H, Wang Y, Qi H, Liu G, Wang R, Shen J.   +5 more
europepmc   +1 more source

HOXB8 promotes invasion and metastasis of high-grade serous ovarian cancer via suppression of the KDM6B/C/EBPα signaling axis. [PDF]

Transl Cancer Res
Xiang L, Lou Y, Wang P, Hu Y, Wang D.
europepmc   +1 more source

Intermittent myopic visual exposure triggers myopia progression via H3K27me3. [PDF]

Genome Med
Lei Y, Lin X, Ling X, Tan Y, Yuan J, Li Y, Di M, Pan Y, Zhong L, Feng Z, Jiao F, Hu C, Deng H, Pan M, Su J, Qu J, Chen W, Zhao F, Zhou X.   +18 more
europepmc   +1 more source

Mesenchymal stem cell-derived miR-125b-1-3p-abundant exosomes alleviate osteoarthritis by modulating the KDM6B-H3K27me3-FOXM1 axis. [PDF]

J Orthop Surg Res
Liu X, Zhou J, Chai B, Xiao Y, Li P, Shi T, Cui R, Zhang G, Jiang S.   +8 more
europepmc   +1 more source

Cadmium Toxicity Effects on Histone Modifiers, Enzyme Activity and Adipokines in Human Adipose Tissue Cells. [PDF]

Molecules
Plata VTG, Barcella JF, Saran RJ, da Silva Neto AF, Martins Ferreira YA, Bolsoni-Lopes A, Oyama LM, Armelin-Correa LM, Alonso-Vale MIC.   +8 more
europepmc   +1 more source

A fusion-deletion genomic-event underlies poor prognosis in young patients with luminal breast cancer. [PDF]

PLoS One
Zheng LW, Liu YM, Yu KD, Liu CC.
europepmc   +1 more source